Gandis Mazeika
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View article: Concordance and test-retest consistency of sleep biomarker-based neurodegenerative disorder profiling
Concordance and test-retest consistency of sleep biomarker-based neurodegenerative disorder profiling Open
Biomarkers that aid in early detection of neurodegeneration are needed to enable early symptomatic treatment and enable identification of people who may benefit from neuroprotective interventions. Increasing evidence suggests that sleep bi…
View article: Concordance and Test-Retest Consistency of Sleep Biomarker-Based Neurodegenerative Disorder Profiling
Concordance and Test-Retest Consistency of Sleep Biomarker-Based Neurodegenerative Disorder Profiling Open
Biomarkers that aid in early detection of neurodegeneration are needed to enable early symptomatic treatment and enable identification of people who may benefit from neuroprotective interventions. Increasing evidence suggests that sleep bi…
View article: P012 Head Position During Sleep: Potential Implications for Patients with Neurodegenerative Disorders
P012 Head Position During Sleep: Potential Implications for Patients with Neurodegenerative Disorders Open
Introduction In 2015, Lee et al. observed sleeping position influenced the efficiency of glymphatic clearance in rats. In 2018, Levendowski et al. reported supine sleep was independently associated with neurodegenerative disorders (NDD)(od…
View article: P025 Atypical N3 Sleep: A Biomarker for Altered Mental Status in Lewy Body Disease?
P025 Atypical N3 Sleep: A Biomarker for Altered Mental Status in Lewy Body Disease? Open
Introduction Atypical N3 sleep (AN3=delta waves with limited theta and sigma) has been associated with ICU delirium and sepsis and averaged 25% of sleep time in Japanese ICU patients. We were interested in exploring whether AN3 might be a …
View article: P022 Sleep Biomarker Phenotyping of Neurodegenerative Disorders Using Artificial Intelligence – A Pilot Study
P022 Sleep Biomarker Phenotyping of Neurodegenerative Disorders Using Artificial Intelligence – A Pilot Study Open
Introduction In this pilot study, we explored sleep biomarker risk probabilities for different neurodegenerative disorder (NDD) phenotypes across a spectrum of NDD patients, compared with controls. Methods We analyzed a cohort of patients …
View article: The Accuracy and Reliability of Sleep Staging and Sleep Biomarkers in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder
The Accuracy and Reliability of Sleep Staging and Sleep Biomarkers in Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder Open
The potential utility of RSWA and stage N3 as neurodegenerative disorder biomarkers was influenced by between-site variability in visual scoring. The degree to which NRH was associated with iRBD was similar to the between-physician agreeme…
View article: 0900 A Community-based Survey of Personal Perspectives Regarding Prodromal Sleep Screening for Neurodegenerative Disorders
0900 A Community-based Survey of Personal Perspectives Regarding Prodromal Sleep Screening for Neurodegenerative Disorders Open
Introduction Sleep markers can assess prodromal risk for neurodegenerative disorders (NDD). In a recent study conducted by the Mayo Clinic, most isolated REM sleep behavior disorder patients preferred knowing about their risk for parkinson…
View article: 0910 Potential Role of Physicians in Addressing the Needs of Those At-Risk of a Neurodegenerative Disorder – A Pilot Survey
0910 Potential Role of Physicians in Addressing the Needs of Those At-Risk of a Neurodegenerative Disorder – A Pilot Survey Open
Introduction In a recent study, most patients diagnosed with isolated REM sleep behavior disorder (iRBD) preferred their physician discussed their risk for developing a future neurodegenerative disorder (NDD) such as parkinsonism or dement…
View article: Non-REM sleep with hypertonia in Parkinsonian Spectrum Disorders: A pilot investigation
Non-REM sleep with hypertonia in Parkinsonian Spectrum Disorders: A pilot investigation Open
In this pilot study, NRH appeared to be a novel candidate sleep biomarker for PSD-related neurodegeneration. Future studies in larger cohorts are needed to confirm these findings, understand the etiology of NRH magnitude/duration, and dete…
View article: 0268 Characterization of Neurodegenerative Disorder Subtypes Based on Non-REM Hypertonia and Sleep Spindle Duration
0268 Characterization of Neurodegenerative Disorder Subtypes Based on Non-REM Hypertonia and Sleep Spindle Duration Open
Introduction Increased non-REM hypertonia (NRH) and decreased sleep spindle-durations were found to be independently associated with patients broadly characterized as presumed Parkinsonian-spectrum disorder [i.e., dementia with Lewy Bodies…
View article: P077 Reliability of the Clinical Characterization of Isolated REM Sleep Behavior Disorder
P077 Reliability of the Clinical Characterization of Isolated REM Sleep Behavior Disorder Open
Purpose Compare agreements between polysomnography-based (PSG) diagnosis of isolated REM-sleep-behavior-disorder (iRBD) and Non-REM-Hypertonia (NRH), a novel biomarker independently associated with synucleinopathy-related neurodegenerative…
View article: P076 Sleep Staging Agreement Between Polysomnography and Sleep Profiler in Isolated REM Sleep Behavior Disorder
P076 Sleep Staging Agreement Between Polysomnography and Sleep Profiler in Isolated REM Sleep Behavior Disorder Open
Purpose Evaluate the sleep staging agreement between polysomnography (PSG) and Sleep Profiler (SP) in patients with suspected isolated REM-sleep-behavior-disorder. Methods Twenty-six patients with reported dream-enactment-behavior (Site1=1…