Gaurav Bhardwaj
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View article: Thulium Fibre Laser Versus Pulse-Modulated Holmium:Yttrium Aluminum Garnet (Ho:YAG) Laser for Endoscopic Lithotripsy: A Systematic Review of Clinical Outcomes, Efficiency, and Safety
Thulium Fibre Laser Versus Pulse-Modulated Holmium:Yttrium Aluminum Garnet (Ho:YAG) Laser for Endoscopic Lithotripsy: A Systematic Review of Clinical Outcomes, Efficiency, and Safety Open
The Holmium:Yttrium Aluminum Garnet (Ho:YAG) laser has been the standard energy source for endoscopic lithotripsy for over two decades; however, limitations such as inefficient energy transmission, strong retropulsion, and large fiber diam…
View article: De Novo Design of High‐Affinity Miniprotein Binders Targeting <i>Francisella Tularensis</i> Virulence Factor
De Novo Design of High‐Affinity Miniprotein Binders Targeting <i>Francisella Tularensis</i> Virulence Factor Open
Francisella tularensis poses considerable public health risk due to its high infectivity and potential for bioterrorism. Francisella‐like lipoprotein (Flpp3), a key virulence factor unique to Francisella, plays critical roles in infection …
View article: De Novo Design of High‐Affinity Miniprotein Binders Targeting <i>Francisella Tularensis</i> Virulence Factor
De Novo Design of High‐Affinity Miniprotein Binders Targeting <i>Francisella Tularensis</i> Virulence Factor Open
Francisella tularensis poses considerable public health risk due to its high infectivity and potential for bioterrorism. Francisella‐like lipoprotein (Flpp3), a key virulence factor unique to Francisella, plays critical roles in infection …
View article: Protein Hunter: exploiting structure hallucination within diffusion for protein design
Protein Hunter: exploiting structure hallucination within diffusion for protein design Open
1 Abstract Interactions between proteins and other biomolecules underlie nearly all biological processes, yet designing such interactions de novo remains challenging. Capturing their specific interactions and co-optimizing sequence and str…
View article: Low-Intensity Extracorporeal Shock Wave Therapy (LI-ESWT) for Erectile Dysfunction in Patients Post-prostatectomy: A Systematic Review
Low-Intensity Extracorporeal Shock Wave Therapy (LI-ESWT) for Erectile Dysfunction in Patients Post-prostatectomy: A Systematic Review Open
Erectile dysfunction (ED) is a common and distressing complication following radical prostatectomy, significantly affecting patients' quality of life. Low-intensity extracorporeal shock wave therapy (LI-ESWT) has emerged as a non-invasive …
View article: Utilisation of artificial intelligence to enhance the detection rates of renal cancer on cross-sectional imaging: protocol for a systematic review and meta-analysis
Utilisation of artificial intelligence to enhance the detection rates of renal cancer on cross-sectional imaging: protocol for a systematic review and meta-analysis Open
Introduction The incidence of renal cell carcinoma has steadily been on the increase due to the increased use of imaging to identify incidental masses. Although survival has also improved because of early detection, overdiagnosis and overt…
View article: De novo design of high-affinity miniprotein binders targeting Francisella tularensis virulence factor
De novo design of high-affinity miniprotein binders targeting Francisella tularensis virulence factor Open
Francisella tularensis poses considerable public health risk due to its high infectivity and potential for bioterrorism. Francisella-like lipoprotein (Flpp3), a key virulence factor unique to Francisella, plays critical roles in infection …
View article: Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning Open
Developing macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource intensive and provide little control over binding mode. Despite progress in protein design, there are currently no r…
View article: Performance analysis of an emergency triage system in ophthalmology using a customized CHATBOT
Performance analysis of an emergency triage system in ophthalmology using a customized CHATBOT Open
Purpose To evaluate the performance of a custom ChatGPT-based chatbot in triaging ophthalmic emergencies compared to trained ophthalmologists. Methods One hundred hypothetical ophthalmic cases were created based on actual patient data from…
View article: Successful Treatment of Chronic Wound in a Patient with Longstanding Shell Injury on Heel using a Novel Product Formulation: A Case Report
Successful Treatment of Chronic Wound in a Patient with Longstanding Shell Injury on Heel using a Novel Product Formulation: A Case Report Open
Introduction: Chronic wounds pose a significant burden on patients’ physical and mental well-being and significantly raise health-care costs. Case report: We report healing with VG111 application alone in a case of chronic wound in a patie…
View article: Accurate<i>de novo</i>design of high-affinity protein binding macrocycles using deep learning
Accurate<i>de novo</i>design of high-affinity protein binding macrocycles using deep learning Open
The development of macrocyclic binders to therapeutic proteins typically relies on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite considerable progress in physics-based metho…
View article: Using artificial intelligence for bladder cancer detection during cystoscopy and its impact on clinical outcomes: a protocol for a systematic review and meta-analysis
Using artificial intelligence for bladder cancer detection during cystoscopy and its impact on clinical outcomes: a protocol for a systematic review and meta-analysis Open
Introduction Cystoscopy has revolutionised the process of diagnosing bladder cancer leading to better categorisation of risk levels and more precise treatment plans. Nonetheless, concerns arise about the lack of uniformity among observers …
View article: Developing a Holistic Framework for Teaching Effectiveness: An Analytical Study on Multiple Dimensions and Stakeholder Perspectives
Developing a Holistic Framework for Teaching Effectiveness: An Analytical Study on Multiple Dimensions and Stakeholder Perspectives Open
Online learning management systems have become well-known resources for students all across the globe. Since the COVID-19 pandemic abruptly shifted conventional education online, there has been a prenominal growth in the number of e-learni…
View article: Investigating relationship between cognitive styles, personality traits, and academic achievement of adolescents
Investigating relationship between cognitive styles, personality traits, and academic achievement of adolescents Open
This study explores the intricate relationships between cognitive styles, personality traits, and academic achievement among adolescents. Cognitive styles refer to the preferred ways individuals process information, while personality trait…
View article: Measuring Teaching Effectiveness: A comprehensive analysis of assessment tools, criteria, and standardization
Measuring Teaching Effectiveness: A comprehensive analysis of assessment tools, criteria, and standardization Open
Students' social and attitude development is said to be influenced by effective instructors just as much as their academic performance. "What makes a good teacher?" is an old and well-studied topic. Teacher effectiveness (TE) has been meas…
View article: Computational Design of Cyclic Peptide Inhibitors of a Bacterial Membrane Lipoprotein Peptidase
Computational Design of Cyclic Peptide Inhibitors of a Bacterial Membrane Lipoprotein Peptidase Open
There remains a critical need for new antibiotics against multi-drug-resistant Gram-negative bacteria, a major global threat that continues to impact mortality rates. Lipoprotein signal peptidase II is an essential enzyme in the lipoprotei…
View article: Expansive discovery of chemically diverse structured macrocyclic oligoamides
Expansive discovery of chemically diverse structured macrocyclic oligoamides Open
Small macrocycles with four or fewer amino acids are among the most potent natural products known, but there is currently no way to systematically generate such compounds. We describe a computational method for identifying ordered macrocyc…
View article: A Tag‐Free Platform for Synthesis and Screening of Cyclic Peptide Libraries
A Tag‐Free Platform for Synthesis and Screening of Cyclic Peptide Libraries Open
In the realm of high‐throughput screening (HTS), macrocyclic peptide libraries traditionally necessitate decoding tags, essential for both library synthesis and identifying hit peptide sequences post‐screening. Our innovation introduces a …
View article: Non-blocking Dynamic Unbounded Graphs with Wait-Free Snapshot
Non-blocking Dynamic Unbounded Graphs with Wait-Free Snapshot Open
Graphs are arguably one of the most fundamental data-structure used in many domains such as block-chain, networks etc. Theoretically and practically, improving Graph performance is one of the most studied and omnipresent research problems.…
View article: A spatiotemporal analysis of Punjab's agricultural diversification
A spatiotemporal analysis of Punjab's agricultural diversification Open
The Indian state of Punjab is well known for its prosperous agrarian position. The amount of different sorts of crops a farmer is cultivating on a specific plot of land is indicated by crop diversification. We have attempted to assess crop…
View article: Learned Lock-free Search Data Structures
Learned Lock-free Search Data Structures Open
Non-blocking search data structures offer scalability with a progress guarantee on high-performance multi-core architectures. In the recent past, "learned queries" have gained remarkable attention. It refers to predicting the rank of a key…
View article: Wait-Free Updates and Range Search using Uruv
Wait-Free Updates and Range Search using Uruv Open
CRUD operations, along with range queries make a highly useful abstract data type (ADT), employed by many dynamic analytics tasks. Despite its wide applications, to our knowledge, no fully wait-free data structure is known to support this …
View article: Soft Soil Gait Planning and Control for Biped Robot using Deep Deterministic Policy Gradient Approach
Soft Soil Gait Planning and Control for Biped Robot using Deep Deterministic Policy Gradient Approach Open
Biped robots have plenty of benefits over wheeled, quadruped, or hexapod robots due to their ability to behave like human beings in tough and non-flat environments. Deformable terrain is another challenge for biped robots as it has to deal…