Ganesh M. Babulal
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View article: Neighborhood support as a protective factor for cognition: Associations with sleep, depression, and stress
Neighborhood support as a protective factor for cognition: Associations with sleep, depression, and stress Open
INTRODUCTION Sleep, depression, stress, and neighborhood support are independently linked to cognition, but how these factors interact when sleep quality is poor remains understudied. METHODS We analyzed cross‐sectional baseline data from …
View article: Nursing Home Segregation and Quality of Care
Nursing Home Segregation and Quality of Care Open
Background Racial segregation is believed to play a critical role in enforcing racial disparities in nursing home quality. In this study, we test whether segregation exacerbates racial disparities in nursing home quality. Methods We used d…
View article: Plasma NfL and cognitive functioning in older adults: The moderating role of HDL cholesterol
Plasma NfL and cognitive functioning in older adults: The moderating role of HDL cholesterol Open
BACKGROUND AND OBJECTIVES Plasma neurofilament light chain (NfL) is a marker of neuroaxonal injury associated with cognitive decline. High‐density lipoprotein (HDL) cholesterol has neuroprotective properties, but its interaction with neuro…
View article: The impact of a participatory intervention to improve learning outcomes and reduce school-based discrimination and community stigma in primary rural schools of Afghanistan: A cluster control randomized trial
The impact of a participatory intervention to improve learning outcomes and reduce school-based discrimination and community stigma in primary rural schools of Afghanistan: A cluster control randomized trial Open
View article: Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression
Networks and clusters of immunometabolic biomarkers and depression-associated features in middle-aged and older community-dwelling US adults with and without depression Open
View article: Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population
Chronic emotional stress and mediating role of Interleukin-6 in the association with cardiometabolic disorders in a multiethnic middle-aged and older US population Open
The study highlights a further aspect of the pathophysiological mechanisms involved in the brain-body communication. While IL-6 partially explains statistical associations between chronic emotional stress and major cardiometabolic disorder…
View article: Naturalistic driving behavior among older adults with and without epilepsy: A pilot study
Naturalistic driving behavior among older adults with and without epilepsy: A pilot study Open
View article: A combined naturalistic driving, clinical, and neurobehavioral data set for investigating aging and dementia
A combined naturalistic driving, clinical, and neurobehavioral data set for investigating aging and dementia Open
Alzheimer's disease and related dementia (ADRD) are becoming increasingly prevalent and are predicted to affect up to 153 million globally by 2050. Outside of biomarkers that measure pathology, there is a lack of methods to quantify and st…
View article: Community engagement, recruitment, and retention of minoritized participants in Alzheimer's disease and related dementia research: A systematic review of disparities
Community engagement, recruitment, and retention of minoritized participants in Alzheimer's disease and related dementia research: A systematic review of disparities Open
INTRODUCTION Ethnoracial groups face the highest risk for Alzheimer's disease and related dementias (ADRD) but remain underrepresented in research, exacerbating health disparities. Understanding barriers and effective recruitment strategie…
View article: Structural and social determinants of dementia risk among adults racialized as Black: Results from a community‐based system dynamics approach
Structural and social determinants of dementia risk among adults racialized as Black: Results from a community‐based system dynamics approach Open
INTRODUCTION Alzheimer's disease and related dementias (ADRD) disproportionately affect Black Americans compared to non‐Hispanic White individuals. We examined perceived dementia risk factors among Black adults in St. Louis via a participa…
View article: Association of environmental exposome and cognitive function among older adults with and without preclinical Alzheimer's disease
Association of environmental exposome and cognitive function among older adults with and without preclinical Alzheimer's disease Open
INTRODUCTION Sociodemographic predictors are established risk factors for Alzheimer's disease (AD), a leading cause of cognitive decline. This study examines the influence of environmental exposures like walkability, green space, and light…
View article: Enhancing participation of historically minoritized groups in Alzheimer disease and related dementias research: National Conference Report
Enhancing participation of historically minoritized groups in Alzheimer disease and related dementias research: National Conference Report Open
This paper reports on a Conference organized by the Washington University School of Medicine's (WUSM) Knight Alzheimer Disease Research Center (Knight ADRC), entitled “Enhancing Participation by Minoritized Groups in Alzheimer Disease and …
View article: The effect of anti-seizure medications on Alzheimer's disease (AD) risk and AD-related symptoms: A scoping review
The effect of anti-seizure medications on Alzheimer's disease (AD) risk and AD-related symptoms: A scoping review Open
Background As the fastest-growing segment of the population, adults over 65 are at the most significant risk for Alzheimer's disease (AD). Older adults often use anti-seizure medications (ASMs), which can negatively impact cognitive functi…
View article: Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease
Updates and future perspectives on neuropsychiatric symptoms in Alzheimer's disease Open
Neuropsychiatric symptoms (NPS) are common throughout the Alzheimer's disease (AD) continuum and profoundly affect patients, caregivers, and health‐care systems. This review synthesizes key research presented in the 2022 and 2023 Alzheimer…
View article: Slowed Driving Reaction Time in Preclinical Alzheimer’s Disease
Slowed Driving Reaction Time in Preclinical Alzheimer’s Disease Open
Driving reaction time (DRT) is one of the most important predictors of motor vehicle crashes in older adults. Although individuals with preclinical Alzheimer’s disease (AD) show subtle cognitive changes that may affect driving, their DRT t…
View article: Identifying major depressive disorder in older adults through naturalistic driving behaviors and machine learning
Identifying major depressive disorder in older adults through naturalistic driving behaviors and machine learning Open
Depression in older adults is often underdiagnosed and has been linked to adverse outcomes, including motor vehicle crashes. With a growing population of older drivers in the United States, innovations in screening methods are needed to id…
View article: Cross‐Sectional Comparison of Structural <scp>MRI</scp> Markers of Impairment in a Diverse Cohort of Older Adults
Cross‐Sectional Comparison of Structural <span>MRI</span> Markers of Impairment in a Diverse Cohort of Older Adults Open
Neurodegeneration is presumed to be the pathological process measure most proximal to clinical symptom onset in Alzheimer Disease (AD). Structural MRI is routinely collected in research and clinical trial settings. Several quantitative MRI…
View article: Characterizing Navigational Changes in Preclinical Alzheimer’s Disease: A Route Complexity Metric Derived From Naturalistic Driving Data
Characterizing Navigational Changes in Preclinical Alzheimer’s Disease: A Route Complexity Metric Derived From Naturalistic Driving Data Open
This study presents a non-invasive, behaviour-based metric that could support early detection of cognitive decline. It may also inform the design of personalized mobility interventions and dementia-friendly mobility systems.
View article: Major Depressive Disorder and Driving Behavior Among Older Adults
Major Depressive Disorder and Driving Behavior Among Older Adults Open
Importance Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression. Objective To exa…
View article: Alzheimer’s disease blood tests of amyloid‐beta 42/40, %p‐tau217, 181, and 205 ratios and MTBR‐243 in real‐world populations: Results from SEABIRD and BioFINDER2
Alzheimer’s disease blood tests of amyloid‐beta 42/40, %p‐tau217, 181, and 205 ratios and MTBR‐243 in real‐world populations: Results from SEABIRD and BioFINDER2 Open
Background Alzheimer’s disease (AD) blood tests that can identify and quantify amyloid plaques, tau tangles, and cognitive and clinical decline are needed in clinical practice, including primary care. However, these tests require validatio…
View article: Exploring the Intersection Between Seizures, Traumatic Brain Injury, and the Risk of Incident Cognitive Impairment in Cognitively Normal Older Adults
Exploring the Intersection Between Seizures, Traumatic Brain Injury, and the Risk of Incident Cognitive Impairment in Cognitively Normal Older Adults Open
Background Seizures, traumatic brain injury (TBI), and dementia increase in prevalence with age. However, the role of seizure and TBI on cognitive impairment risk (CI) is unclear. This study investigated how a diagnosis of seizures and TBI…
View article: Diversity in Sociodemographic and Linguistic landscape: Perspectives from Chinese American, Mexican American, and Indian Cohorts
Diversity in Sociodemographic and Linguistic landscape: Perspectives from Chinese American, Mexican American, and Indian Cohorts Open
Background Nearly half the world’s population is bi‐ or multilingual, where diverse interpretations of bilingualism with varying associated sociodemographic factors may lead to inconsistent conclusions in bilingualism and cognitive researc…
View article: Driving Behavior as a Functional Biomarker of Preclinical Alzheimer Disease
Driving Behavior as a Functional Biomarker of Preclinical Alzheimer Disease Open
Background Trip chaining occurs when a driver departs from an origin and travels to multiple locations before returning. Increased trip complexity may require higher levels of executive function, memory, and navigational abilities. Subtle …
View article: Dementia Risk and Social Determinants of Health Among Adults Racialized as Black: A Community-Based System Dynamics Perspective
Dementia Risk and Social Determinants of Health Among Adults Racialized as Black: A Community-Based System Dynamics Perspective Open
Background The aging population in the USA is projected to increase significantly, with a corresponding rise in dementia cases, particularly among racial minorities. This study examines the key drivers of racial disparities in dementia ris…
View article: Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research Open
Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD …
View article: Identifying Gaps and Barriers in Alzheimer’s Disease and Related Dementia Research and Management in Low- and Middle-Income Countries: A Survey of Health Professionals and Researchers
Identifying Gaps and Barriers in Alzheimer’s Disease and Related Dementia Research and Management in Low- and Middle-Income Countries: A Survey of Health Professionals and Researchers Open
Background: The significant increase in Alzheimer’s disease and related dementia prevalence is a global health crisis, acutely impacting low- and lower-middle and upper-middle-income countries (LLMICs/UMICs). Objective: The objective of th…
View article: Physical Activity and Neurocognitive Symptoms in Older Adults During COVID-19 Pandemic
Physical Activity and Neurocognitive Symptoms in Older Adults During COVID-19 Pandemic Open
Objectives: Examine whether physical activity (PA) changes during the COVID-19 pandemic were related to subjective cognitive decline (SCD), depression, and anxiety in older adults and whether these varied by sociodemographic variables. Met…
View article: Derivation of Indices of Cognitive Change Among Hispanic Adults and Elders
Derivation of Indices of Cognitive Change Among Hispanic Adults and Elders Open
Importance Determining the influence of race and ethnicity on change in cognitive test performance has significant implications for clinical practice and research in populations at risk for Alzheimer disease. Objective To evaluate the sign…
View article: Traumatic Brain Injury, Seizures, and Cognitive Impairment Among Older Adults
Traumatic Brain Injury, Seizures, and Cognitive Impairment Among Older Adults Open
Importance Traumatic brain injury (TBI), seizures, and dementia increase with age. There is a gap in understanding the associations of TBI, seizures, and medications such as antiseizure and antipsychotics with the progression of cognitive …
View article: Cognition Mediates the Association Between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric Symptoms
Cognition Mediates the Association Between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric Symptoms Open
Background: Neuropsychiatric symptoms (NPS) can be an early manifestation of Alzheimer’s disease (AD). However, the associations among NPS, cognition, and AD biomarkers across the disease spectrum are unclear. Objective: We analyzed cross-…