Yugang Dong
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View article: Associations between High Protein Intake and Cardiovascular Diseases by Age Groups: A Cohort Study
Associations between High Protein Intake and Cardiovascular Diseases by Age Groups: A Cohort Study Open
View article: Relief of Refractory Angina With Vericiguat
Relief of Refractory Angina With Vericiguat Open
Vericiguat may offer therapeutic benefit in refractory angina patients unresponsive to conventional therapy. Further investigation is warranted.
View article: Effect of empagliflozin on fractional excretion of sodium in patients with cirrhosis and refractory ascites
Effect of empagliflozin on fractional excretion of sodium in patients with cirrhosis and refractory ascites Open
BACKGROUND Ascites is the most common complication of cirrhosis. Current pharmacological interventions, such as diuretics, often become ineffective in advanced stages due to diuretic resistance. Sodium-glucose co-transporter 2 (SGLT2) inhi…
View article: Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial
Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial Open
Ascentage Pharma Group Corp Ltd. (Hong Kong).
View article: Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts
Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts Open
Deficiency of the myocardial microcirculation plays a role in the pathogenesis of heart failure (HF). We aimed to investigate the association of myocardial blood flow (MBF) and the retinal microvasculature with left ventricular (LV) functi…
View article: Appraisal of β-Blocker Use in Patients with Cardiovascular Disease and Chronic Obstructive Pulmonary Disease
Appraisal of β-Blocker Use in Patients with Cardiovascular Disease and Chronic Obstructive Pulmonary Disease Open
View article: Inspecting the risk of heart failure in general population using metabolic health status and obesity profiles
Inspecting the risk of heart failure in general population using metabolic health status and obesity profiles Open
Background: Obesity and metabolic unhealth don’t always co-exist as the risk factors of heart failure (HF). Phenotypes derived from obesity and metabolic unhealth have promising clinical relevance. Their predictive effect for different sub…
View article: Estimating pulmonary arterial pressure from 4D flow images
Estimating pulmonary arterial pressure from 4D flow images Open
The non-invasive method for estimating the pulmonary arterial pressure (PAP) plays an important role in the screening and diagnosis of pulmonary arterial hypertension (PAH). We aimed to establish a phase-contrast magnetic resonance imaging…
View article: Target Achievements of Low-Density Lipoprotein Cholesterol, Blood Pressure, and Glucose in Patients with Diabetes after Acute Coronary Syndrome: Findings from the Chinese Cardiovascular Association Database – iHeart Project
Target Achievements of Low-Density Lipoprotein Cholesterol, Blood Pressure, and Glucose in Patients with Diabetes after Acute Coronary Syndrome: Findings from the Chinese Cardiovascular Association Database – iHeart Project Open
Aim: To evaluate the achievement of metabolic risk factor targets and influencing factors in ACS patients with diabetes during the 12 months after discharge. Methods: We retrospectively analyzed data from the Chinese Cardiovascular Associa…
View article: Cardiovascular Outcomes and Variability in Plasma Lipid Levels Across Body Mass Index Categories: The ARIC Study
Cardiovascular Outcomes and Variability in Plasma Lipid Levels Across Body Mass Index Categories: The ARIC Study Open
The aim of this study was to investigate associations of cardiovascular outcomes with lipid variability across body mass index categories. We identified 6689 participants (57.1% women) enrolled in the Atherosclerosis Risk In Communities (A…
View article: Maf1 Ameliorates Cardiac Fibrosis by Regulating Sfrp2
Maf1 Ameliorates Cardiac Fibrosis by Regulating Sfrp2 Open
View article: Air pollution, genetic susceptibility, and the risk of ventricular arrhythmias: a prospective cohort study in the UK Biobank
Air pollution, genetic susceptibility, and the risk of ventricular arrhythmias: a prospective cohort study in the UK Biobank Open
Aims Both genetic and environmental factors contribute to the development of ventricular arrhythmias (VAs). However, the extent to which genetic susceptibility modifies the effects of air pollutants on the risk of VAs remains poorly unders…
View article: Progress and Hotspot Analysis of Bibliometric-Based Research on Agricultural Irrigation Patterns on Non-Point Pollution
Progress and Hotspot Analysis of Bibliometric-Based Research on Agricultural Irrigation Patterns on Non-Point Pollution Open
With the constant advancement of irrigation technology and the continuous expansion of irrigation areas, non-point source pollution (NPS) caused by agricultural activities has posed a persistent threat to ecosystems and biological safety. …
View article: Multifactorial Analysis of the Effect of Applied Gamma-Polyglutamic Acid on Soil Infiltration Characteristics
Multifactorial Analysis of the Effect of Applied Gamma-Polyglutamic Acid on Soil Infiltration Characteristics Open
To investigate the mechanism and influence of applying gamma-polyglutamic acid (γ-PGA) on soil water infiltration, laboratory experiments and numerical simulations were conducted using Hydrus-1D. These studies assessed the impact of variou…
View article: Atherogenic lipid profile in patients with statin treatment after acute coronary syndrome: a real-world analysis from Chinese cardiovascular association database
Atherogenic lipid profile in patients with statin treatment after acute coronary syndrome: a real-world analysis from Chinese cardiovascular association database Open
View article: The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial
The traditional Chinese medicine Qiliqiangxin in heart failure with reduced ejection fraction: a randomized, double-blind, placebo-controlled trial Open
View article: The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation
The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation Open
One of the features of pathological cardiac hypertrophy is enhanced translation and protein synthesis. Translational inhibition has been shown to be an effective means of treating cardiac hypertrophy, although system-wide side effects are …
View article: Estimated pulse wave velocity predicts mortality in patients with heart failure with preserved ejection fraction
Estimated pulse wave velocity predicts mortality in patients with heart failure with preserved ejection fraction Open
These results suggested ePWV is independently associated with increased all-cause mortality and CVD mortality in HFpEF patients, indicating ePWV is an appropriate predictor of prognosis in patients with HFpEF.
View article: Mortality in patients admitted to hospital with heart failure in China: a nationwide Cardiovascular Association Database-Heart Failure Centre Registry cohort study
Mortality in patients admitted to hospital with heart failure in China: a nationwide Cardiovascular Association Database-Heart Failure Centre Registry cohort study Open
For the Chinese translation of the abstract see Supplementary Materials section.
View article: Long-term prognostic value of thyroid hormones in left ventricular noncompaction
Long-term prognostic value of thyroid hormones in left ventricular noncompaction Open
View article: S<sub>2</sub>I<sub>2</sub>N<sub>0–3</sub> score predicts short‐ and long‐term mortality and morbidity in HFrEF: a post‐hoc analysis of the GUIDE‐IT trial
S<sub>2</sub>I<sub>2</sub>N<sub>0–3</sub> score predicts short‐ and long‐term mortality and morbidity in HFrEF: a post‐hoc analysis of the GUIDE‐IT trial Open
Aims This study investigated the S 2 I 2 N 0–3 score, a simple tool comprising stroke history, insulin‐treated diabetes, and N‐terminal pro‐brain natriuretic peptide, for forecasting mortality and morbidity in heart failure (HF) with reduc…
View article: Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry
Edoxaban for stroke prevention in atrial fibrillation and factors associated with dosing: patient characteristics from the prospective observational ETNA-AF-China registry Open
Real-world data on effectiveness and safety of a single non-vitamin K antagonist oral anticoagulant in the Chinese population with atrial fibrillation (AF) are limited. This study reports characteristics of patients treated with edoxaban a…
View article: Effectiveness and safety of ivabradine in Chinese patients with chronic heart failure: an observational study
Effectiveness and safety of ivabradine in Chinese patients with chronic heart failure: an observational study Open
Aims A therapeutic strategy for chronic heart failure (HF) is to lower resting heart rate (HR). Ivabradine is a well‐known HR‐lowering agent, but limited prospective data exist regarding its use in Chinese patients. This study aimed to eva…
View article: Causal Associations of Socioeconomic Status, Intelligence, and Cognitive Function with Heart Failure Risk: A Multivariable Mendelian Randomization Study
Causal Associations of Socioeconomic Status, Intelligence, and Cognitive Function with Heart Failure Risk: A Multivariable Mendelian Randomization Study Open
View article: High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA
High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA Open
View article: P539: A PHASE 1 STUDY OF HMPL-306, A DUAL INHIBITOR OF MUTANT ISOCITRATE DEHYDROGENASE (IDH) 1 AND 2, IN PTS WITH RELAPSED/REFRACTORY MYELOID HEMATOLOGICAL MALIGNANCIES HARBORING IDH1 AND/OR 2 MUTATIONS
P539: A PHASE 1 STUDY OF HMPL-306, A DUAL INHIBITOR OF MUTANT ISOCITRATE DEHYDROGENASE (IDH) 1 AND 2, IN PTS WITH RELAPSED/REFRACTORY MYELOID HEMATOLOGICAL MALIGNANCIES HARBORING IDH1 AND/OR 2 MUTATIONS Open
Topic: 16. Myeloproliferative neoplasms - Clinical Background: HMPL-306 is a potent selective inhibitor of mutant IDH1/2. Aims: The phase 1 study aimed to evaluate safety, tolerability, recommended phase 2 study (RP2D), pharmacokinetics/ph…
View article: Association between epicardial adipose tissue and incident heart failure mediating by alteration of natriuretic peptide and myocardial strain
Association between epicardial adipose tissue and incident heart failure mediating by alteration of natriuretic peptide and myocardial strain Open
Background Epicardial adipose tissue (EAT) has been suggested to exert deleterious effects on myocardium and cardiovascular disease (CVD) consequence. We evaluated the associations of EAT thickness with adverse outcomes and its potential m…
View article: Comparison of liver fibrosis scores for predicting mortality and morbidity in heart failure with preserved ejection fraction
Comparison of liver fibrosis scores for predicting mortality and morbidity in heart failure with preserved ejection fraction Open
Aims Liver fibrosis scores (LFSs) are non‐invasive and effective tools for estimating cardiovascular risks. To better understand the advantages and limitations of currently available LFSs, we determined to compare the predictive values of …
View article: Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction Open
Aims This study aims to evaluate the prognostic value of mean corpuscular haemoglobin concentration (MCHC) on clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Methods and results We analysed HFpEF …
View article: Efficacy and Safety of Qiliqiangxin in Patients with Heart Failure and Reduced Ejection Fraction:&nbsp;The QUEST Randomised Clinical Trial
Efficacy and Safety of Qiliqiangxin in Patients with Heart Failure and Reduced Ejection Fraction: The QUEST Randomised Clinical Trial Open