Gangcheng Zhang
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View article: Ten-year survival, trends and risk stratification of newly diagnosed idiopathic pulmonary arterial hypertension in China: insights from a national multicenter prospective registry
Ten-year survival, trends and risk stratification of newly diagnosed idiopathic pulmonary arterial hypertension in China: insights from a national multicenter prospective registry Open
Background Data on the 10-year survival of incident IPAH in China is lacking. The changing trend of characteristics and survival of IPAH over the past decade has yet been demonstrated. The 4-stratum risk model needs further validation in d…
View article: Biodegradable Pansy® occluder for patent foramen ovale closure: a multicenter, single-arm, prospective study
Biodegradable Pansy® occluder for patent foramen ovale closure: a multicenter, single-arm, prospective study Open
Background The next-generation closure device for interventional treatment of patent foramen ovale (PFO) is regarded as biodegradable, yet the corresponding biomaterial technique is still challenging. Herein, we report the clinical applica…
View article: Exercise‐Induced Oxygen Desaturation and Heart Rate Response During 6‐Min Walk Test Predict Pulmonary Hypertension in Exertional Dyspnea: A Retrospective Cohort Study
Exercise‐Induced Oxygen Desaturation and Heart Rate Response During 6‐Min Walk Test Predict Pulmonary Hypertension in Exertional Dyspnea: A Retrospective Cohort Study Open
Pulmonary hypertension (PH) is a life‐threatening condition frequently associated with exertional dyspnea. It remains diagnostically challenging due to limitations in current screening modalities. While the 6‐min walk test (6MWT) has been …
View article: 2025 Chinese Expert Consensus on Clinical Applications of Biodegradable Patent Foramen Ovale Occluders
2025 Chinese Expert Consensus on Clinical Applications of Biodegradable Patent Foramen Ovale Occluders Open
View article: Rationale and design of the SPRING trail: effectivity and safety of Pfo closuRe vs medIcine in alleviatiNg migraine, a multicenter, randomized and open-label trail
Rationale and design of the SPRING trail: effectivity and safety of Pfo closuRe vs medIcine in alleviatiNg migraine, a multicenter, randomized and open-label trail Open
Background Migraine is a leading cause of disability worldwide. Several retrospective studies have suggested that the closure of the Patent Foramen Ovale (PFO) may provide relief from migraines. However, three randomized controlled trials …
View article: A framework for mining lifestyle profiles through multi-dimensional and high-order mobility feature clustering
A framework for mining lifestyle profiles through multi-dimensional and high-order mobility feature clustering Open
Human mobility demonstrates a high degree of regularity, which facilitates the discovery of lifestyle profiles. Existing research has yet to fully utilize the regularities embedded in high-order features extracted from human mobility recor…
View article: Safety profile of intravenous digoxin in Chinese patients with acute heart failure with reduced ejection fraction: a small-scale prospective cohort study
Safety profile of intravenous digoxin in Chinese patients with acute heart failure with reduced ejection fraction: a small-scale prospective cohort study Open
Background: Adverse effects of intravenous digoxin vary from patients and disease status, which should be closely monitored. Aims: To explore the safety profile of intravenous digoxin in acute heart failure with reduced ejection fraction (…
View article: Clinical features and long-term survival in idiopathic pulmonary arterial hypertension with thyroid dysfunction: insights from a national multicentre prospective study
Clinical features and long-term survival in idiopathic pulmonary arterial hypertension with thyroid dysfunction: insights from a national multicentre prospective study Open
Background Our objective was to clarify the characteristics and long-term survival of idiopathic pulmonary arterial hypertension (IPAH) patients with thyroid dysfunction and compare them with IPAH without thyroid dysfunction. Methods A ret…
View article: A sham-controlled randomised trial of pulmonary artery denervation for Group 1 pulmonary arterial hypertension: one-year outcomes of the PADN-CFDA trial
A sham-controlled randomised trial of pulmonary artery denervation for Group 1 pulmonary arterial hypertension: one-year outcomes of the PADN-CFDA trial Open
In this multicentre sham-controlled randomised trial, PADN treatment for Group 1 PAH significantly reduced clinical worsening and improved the 6MWD during 1-year follow-up in patients treated with a PDE-5i.
View article: Effectiveness and feasibility of transcatheter aortic valve replacement in treating combined aortic and mitral regurgitation: a retrospective observational study
Effectiveness and feasibility of transcatheter aortic valve replacement in treating combined aortic and mitral regurgitation: a retrospective observational study Open
TAVR is effective and feasible for high-risk patients with combined aortic and mitral regurgitation.
View article: Agitated saline with 10% blood increases number and stability of microbubbles in detection right-to-left shunt by contrast-enhanced transcranial Doppler: an in vitro and in vivo observational study
Agitated saline with 10% blood increases number and stability of microbubbles in detection right-to-left shunt by contrast-enhanced transcranial Doppler: an in vitro and in vivo observational study Open
The 10% BAS would be suggested in c-TCD as it addressed larger RLS by increasing the number and stability of microbubbles, and it improves the diagnosis of patent foramen ovale (PFO).
View article: 10-year survival of pulmonary arterial hypertension associated with connective tissue disease: insights from a multicentre PAH registry
10-year survival of pulmonary arterial hypertension associated with connective tissue disease: insights from a multicentre PAH registry Open
Objectives To report the 10-year survival rate and prognostic factors of pulmonary arterial hypertension associated with CTD (CTD-PAH) patients, to compare treatment and survival between patients enrolled before and after 2015, and to vali…
View article: Bile acid predicts congenital portosystemic venous shunt in patients with pulmonary arterial hypertension
Bile acid predicts congenital portosystemic venous shunt in patients with pulmonary arterial hypertension Open
The etiology of pulmonary arterial hypertension (PAH) is complex, especially the investigation of rare pathogeny is difficult. Congenital portosystemic venous shunt (CPSS) is a rare congenital anomaly in which the portal blood completely o…
View article: Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine: A Clinical Trial
Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine: A Clinical Trial Open
Background: Transcatheter closure of patent foramen ovale (PFO) has been widely accepted as a highly effective way to treat high-risk PFO-related diseases. However, traditional non-degradable occluders made of metal alloys will perm…
View article: Characteristics, Long-term Survival, and Risk Assessment of Pediatric Pulmonary Arterial Hypertension in China
Characteristics, Long-term Survival, and Risk Assessment of Pediatric Pulmonary Arterial Hypertension in China Open
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View article: Machine learning in a real-world PFO study: analysis of data from multi-centers in China
Machine learning in a real-world PFO study: analysis of data from multi-centers in China Open
View article: Pulmonary Artery Denervation for Pulmonary Arterial Hypertension
Pulmonary Artery Denervation for Pulmonary Arterial Hypertension Open
In patients with WHO group 1 PAH, PADN improved exercise capacity, hemodynamic status, and clinical outcomes during 6-month follow-up. (Safety and Efficacy of Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension [P…
View article: Long-term mortality after pulmonary artery denervation stratified by baseline functional class in patients with pulmonary arterial hypertension
Long-term mortality after pulmonary artery denervation stratified by baseline functional class in patients with pulmonary arterial hypertension Open
PADN results in significant improvements in survival at long-term follow-up, especially in patients with PAH in FC 3-4. This study was the continuation of the PADN-1 study which was registered at URL: http://www.chictr.trc.com.cn. Unique i…
View article: Pulmonary Artery Denervation for Pulmonary Arterial Hypertension: A Sham-Controlled Randomised Trial
Pulmonary Artery Denervation for Pulmonary Arterial Hypertension: A Sham-Controlled Randomised Trial Open
View article: Risk prediction in medically treated chronic thromboembolic pulmonary hypertension
Risk prediction in medically treated chronic thromboembolic pulmonary hypertension Open
View article: Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions
Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions Open
Quantitative RV fast strain and strain rate parameters assessed from CMR identify abnormalities of RV function in rTOF and PAH and are predictive of exercise capacity, RV decompensation and clinical risks in these patients. Trial registry …
View article: [Effect of calorie-enriched formula on postoperative catch-up growth in infants with cyanotic congenital heart disease: a propective randomized controlled study].
[Effect of calorie-enriched formula on postoperative catch-up growth in infants with cyanotic congenital heart disease: a propective randomized controlled study]. Open
Compared with the standard formula, calorie-enriched formula can better help with postoperative catch-up growth in infants with cyanotic CHD.
View article: Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions
Cardiovascular magnetic resonance‐assessed fast global longitudinal strain parameters add diagnostic and prognostic insights in right ventricular volume and pressure loading disease conditions Open
Background Parameters of myocardial deformation may provide improved insights into right ventricular (RV) dysfunction. We quantified RV longitudinal myocardial function using a fast, semi-automated method and investigated its diagnostic an…
View article: Where the congenital heart disease meets the pulmonary arterial hypertension, FLNA matters: a case report and literature review
Where the congenital heart disease meets the pulmonary arterial hypertension, FLNA matters: a case report and literature review Open
View article: Effect of ambrisentan on echocardiographic and Doppler measures from patients in China with pulmonary arterial hypertension
Effect of ambrisentan on echocardiographic and Doppler measures from patients in China with pulmonary arterial hypertension Open
Significant improvements in a number of RV echocardiographic parameters were observed at Weeks 12 and 24 after ambrisentan treatment in patients with PAH.
View article: Efficacy and safety of ambrisentan in Chinese patients with connective tissue disease-pulmonary arterial hypertension: a post-hoc analysis
Efficacy and safety of ambrisentan in Chinese patients with connective tissue disease-pulmonary arterial hypertension: a post-hoc analysis Open
View article: Serum IgM against SARS-CoV-2 correlates with in-hospital mortality in severe/critical patients with COVID-19 in Wuhan, China
Serum IgM against SARS-CoV-2 correlates with in-hospital mortality in severe/critical patients with COVID-19 in Wuhan, China Open
Severe/critical patients with coronavirus disease 2019 (COVID-19) have become the central issue in the current global pandemic due to their high mortality rate. However, the relationship between antibody response and clinical outcomes has …
View article: Understanding the current status of patients with pulmonary hypertension during COVID‐19 outbreak: a small‐scale national survey from China
Understanding the current status of patients with pulmonary hypertension during COVID‐19 outbreak: a small‐scale national survey from China Open
Pulmonary hypertension is a chronic disease developing progressively with high mortality. Pulmonary hypertension patients need persistent medical care; however, limited reports focused on them when there was an outbreak of coronavirus dise…
View article: Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial
Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial Open
Rationale: Oral treprostinil improves exercise capacity in patients with pulmonary arterial hypertension (PAH), but the effect on clinical outcomes was unknown.Objectives: To evaluate the effect of oral treprostinil compared …
View article: Correlation between right ventricular–pulmonary artery coupling and the prognosis of patients with pulmonary arterial hypertension
Correlation between right ventricular–pulmonary artery coupling and the prognosis of patients with pulmonary arterial hypertension Open
This study aimed to analyze the correlation between the efficiency coefficient of right ventricular–pulmonary artery coupling ( η vv ) and the prognosis of patients with pulmonary arterial hypertension (PAH). A total of 64 patients who und…