Guang Yang
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View article: Early Detection of Chemotherapy‐Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium ( <sup>2</sup> H) Metabolic Imaging: in Vitro and in Vivo Assessments
Early Detection of Chemotherapy‐Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium ( <sup>2</sup> H) Metabolic Imaging: in Vitro and in Vivo Assessments Open
Deuterium metabolic imaging (DMI) is a promising noninvasive technique for assessing tumor metabolism, yet its application in bladder cancer (BCa) remains unexplored. This study presents the first demonstration of DMI for evaluating therap…
View article: Transfer learning-driven prediction of oil and gaspipeline corrosion rates in small sample scenarios
Transfer learning-driven prediction of oil and gaspipeline corrosion rates in small sample scenarios Open
To ensure the safe operation of oil and gas pipeline systems in complex environments, accurately predicting the corrosion rate of natural gas well pipes is of paramount importance. Given the widespread challenge of pipe corrosion in the oi…
View article: CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis
CHP1 promotes lipid droplet growth and regulates the localization of key enzymes for triacylglycerol synthesis Open
The glycerol-3-phosphate (G-3-P) pathway is central to the synthesis of triacylglycerols (TAGs) and glycerophospholipids, essential for membrane biogenesis and lipid storage. The first and rate-limiting step in this pathway is catalyzed by…
View article: Identifications of Genes Involved in ABA and MAPK Signaling Pathways Positively Regulating Cold Tolerance in Rice
Identifications of Genes Involved in ABA and MAPK Signaling Pathways Positively Regulating Cold Tolerance in Rice Open
Cold stress (CS) significantly impacts rice (Oryza sativa L.) growth during seedling and heading stages. Based on two-year field observations, this study identified two rice lines, L9 (cold stress-sensitive) and LD18 (cold stress-tolerant)…
View article: Regulating Perovskite/Pcbm Interface for Highly Efficient and Stable Inverted Perovskite Solar Cells
Regulating Perovskite/Pcbm Interface for Highly Efficient and Stable Inverted Perovskite Solar Cells Open
View article: Brain temperature mapping based on chemical exchange saturation transfer signal at 2 ppm
Brain temperature mapping based on chemical exchange saturation transfer signal at 2 ppm Open
The CEST-based approach proposed in this study suggests a path toward label-free brain thermometry in vivo at high resolution and may be potentially applied in other tissues such as muscle and kidney.
View article: Improving genomic prediction accuracy of pig reproductive traits based on genotype imputation using preselected markers with different imputation platforms
Improving genomic prediction accuracy of pig reproductive traits based on genotype imputation using preselected markers with different imputation platforms Open
Genomic prediction has been widely applied to the pig industry and has greatly accelerated the progress of genetic improvement in pigs. With the development of sequencing technology and price reduction, more and more genotype imputation pa…
View article: Enhanced Glycosylation Caused by Overexpression of Rv1002c in a Recombinant BCG Promotes Immune Response and Protects against Mycobacterium tuberculosis Infection
Enhanced Glycosylation Caused by Overexpression of Rv1002c in a Recombinant BCG Promotes Immune Response and Protects against Mycobacterium tuberculosis Infection Open
Tuberculosis (TB) is a major global health threat despite its virtual elimination in developed countries. Issues such as drug accessibility, emergence of multidrug-resistant strains, and limitations of the current BCG vaccine highlight the…
View article: Letter to the Editor: Limitations of acetylcholinesterase inhibitor therapy for Alzheimer’s disease
Letter to the Editor: Limitations of acetylcholinesterase inhibitor therapy for Alzheimer’s disease Open
aDepartment of Neurology, Kunshan Hospital of Traditional Chinese Medicine,Kunshan bInstitute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China cSouthwest Medic…
View article: Identifications of genes involved in ABA and MAPK signaling pathways positively regulating cold tolerance in rice
Identifications of genes involved in ABA and MAPK signaling pathways positively regulating cold tolerance in rice Open
Cold stress (CS) significantly impacts rice growth during seedling and heading stages. This study based on two-year field observations identified two rice lines, L9 (cold stress-sensitive) and LD18 (cold stress-tolerant) showing contrastin…
View article: QTL-seq analysis identified the genomic regions of plant height and days to heading in high-latitude rice
QTL-seq analysis identified the genomic regions of plant height and days to heading in high-latitude rice Open
Introduction: Rice ( Oryza sativa L.) is one of the most extensive crops in the world. China’s Heilongjiang Province is the northernmost rice-growing region in the world. However, rice cultivars suitable for growth in low-latitude regions …
View article: Facile construction of ZIF-94/PAN nanofiber by electrospinning for the removal of Co(II) from wastewater
Facile construction of ZIF-94/PAN nanofiber by electrospinning for the removal of Co(II) from wastewater Open
View article: Revisiting the Benefits of Exercise for Alzheimer's Disease through the Lens of Ferroptosis: A New Perspective
Revisiting the Benefits of Exercise for Alzheimer's Disease through the Lens of Ferroptosis: A New Perspective Open
Ferroptosis, an iron-dependent form of programmed cell death driven by oxidative stress, plays a crucial role in the progression of Alzheimer's disease (AD). Aging diminishes antioxidant systems that maintain iron homeostasis, particularly…
View article: CCDC 2299360: Experimental Crystal Structure Determination
CCDC 2299360: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Study on the characteristics of soil erosion on different land use slopes and its influencing factors in the Loess Hilly and Gully Region
Study on the characteristics of soil erosion on different land use slopes and its influencing factors in the Loess Hilly and Gully Region Open
In order to explore the characteristics and influencing factors of soil and water loss on different land use slopes in the loess hilly and gully region, based on the monitoring data of runoff plots in the soil and water conservation monito…
View article: CSD 2211088: Experimental Crystal Structure Determination
CSD 2211088: Experimental Crystal Structure Determination Open
An entry from the Inorganic Crystal Structure Database, the world’s repository for inorganic crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely availabl…
View article: Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection
Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection Open
Described herein is the first-time disclosure of Linvencorvir (RG7907), a clinical compound and a hepatitis B virus (HBV) core protein allosteric modulator, for the treatment of chronic HBV infection. Built upon the core structure of heter…
View article: Genome-wide association study uncovers major genetic loci associated with flowering time in response to active accumulated temperature in wild soybean population
Genome-wide association study uncovers major genetic loci associated with flowering time in response to active accumulated temperature in wild soybean population Open
View article: The Mechanisms of Current Platinum Anticancer Drug Resistance in the Glioma
The Mechanisms of Current Platinum Anticancer Drug Resistance in the Glioma Open
Gliomas are the most common and malignant primary tumors of the central nervous system (CNS). Glioblastomas are the most malignant and aggressive form of primary brain tumors and account for the majority of brain tumor-related deaths. The …
View article: Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis
Inositol hexakisphosphate primes syndapin I/PACSIN 1 activation in endocytosis Open
View article: Structural insights into Ras regulation by SIN1
Structural insights into Ras regulation by SIN1 Open
Significance Both the mTORC2 and Ras-ERK pathways respond to growth factor stimulation and play critical roles in cell growth and proliferation, disarray of these pathways leads to many diseases, especially cancer. These two signaling path…
View article: <i>GmMDE</i> genes bridge the maturity gene <i>E1</i> and florigens in photoperiodic regulation of flowering in soybean
<i>GmMDE</i> genes bridge the maturity gene <i>E1</i> and florigens in photoperiodic regulation of flowering in soybean Open
Soybean (Glycine max) is highly sensitive to photoperiod, which affects flowering time and plant architecture and thus limits the distribution range of elite soybean cultivars. The major maturity gene E1 confers the most prominent effect o…
View article: Localization of QTL for cold tolerance at the germination stage of rice (Oryza sativa L.) using recombinant inbred lines
Localization of QTL for cold tolerance at the germination stage of rice (Oryza sativa L.) using recombinant inbred lines Open
The cold tolerance of germinating direct-sown rice ( Oryza sativa L.) has an increased rate of emergence, which ensures vigorous seedling growth. Research on QTL localization for cold tolerance at the germination stage can assist in molecu…
View article: Additional file 1 of Genome-wide association study uncovers major genetic loci associated with flowering time in response to active accumulated temperature in wild soybean population
Additional file 1 of Genome-wide association study uncovers major genetic loci associated with flowering time in response to active accumulated temperature in wild soybean population Open
Additional file 1: Table S1. Prier used in this study. Table S2. List of 392 Glycine soja accessions and acumulated temperature zones. Table S3. 92 SNPs that significantly associated with flowering time in average across the two-year exper…
View article: Study On Spectral Characters-Chlorophyll Inversion Model of Sabina Vulgaris in Mu Us Sandy Land
Study On Spectral Characters-Chlorophyll Inversion Model of Sabina Vulgaris in Mu Us Sandy Land Open
Sabina vulgaris is a group tree species in Mu Us Sandy Land. Understanding the growth status of Sabina vulgaris has guiding value for vegetation change monitoring. Chlorophyll is an important indicator to characterize the growth status of …
View article: Anastomosis oversewing technique to prevent leakage after oesophagectomy: a propensity score-matched analysis
Anastomosis oversewing technique to prevent leakage after oesophagectomy: a propensity score-matched analysis Open
OBJECTIVES Oesophagogastric anastomosis is a core part of oesophagectomy, and anastomotic leakage is among its main concerns. We used the oversewing technique to reinforce the anastomosis created with a circular stapler. This study investi…
View article: Dissecting the biology of mTORC1 beyond rapamycin
Dissecting the biology of mTORC1 beyond rapamycin Open
RapaLink1 enables differentiation between functions mediated by the closely related mTORC1 and mTORC2.
View article: Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1
Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1 Open
The PI3K/MTOR signalling network regulates a broad array of critical cellular processes, including cell growth, metabolism and autophagy. The mechanistic target of rapamycin (MTOR) kinase functions as a core catalytic subunit in two physic…
View article: Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis.
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. Open
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previ…
View article: Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis
Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis Open
The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previ…