Ganglei Li
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The S1PR1–CCN1 axis drives endothelial-to-mesenchymal transition and vascular instability in brain arteriovenous malformations Open
Our study identifies the S1PR1-CCN1 axis as a critical regulator of endothelial plasticity in bAVMs. S1PR1 knockdown promotes an EndoMT-like phenotype and enhances endothelial migration, although CCN1 acts as a downstream effector mediatin…
Critical roles and clinical perspectives of RNA methylation in cancer Open
RNA modification, especially RNA methylation, is a critical posttranscriptional process influencing cellular functions and disease progression, accounting for over 60% of all RNA modifications. It plays a significant role in RNA metabolism…
RETRACTED: A Wnt pathway-associated model and nomogram predict the outcome of GBM patients Open
The authors have requested that this preprint be removed from Research Square.
Tryptophan metabolism in health and disease Open
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, met…
Post-acute phase Rac1/Pak1/p38/β-catenin signalling activation promotes ischemic recovery and facilitates migration of neural stem cells Open
Ischemic stroke is one of the world's leading causes of death and disability. During ischemic stroke, neuronal death is caused by inflammation, oxidative stress, apoptosis, and excitatory toxicity. For a long time, there has been a lot of …
Health and Disease:<i>Akkermansia muciniphila</i>, the Shining Star of the Gut Flora Open
Akkermansia muciniphila ( A. muciniphila ) has drawn much attention as an important gut microbe strain in recent years. A. muciniphila can influence the occurrence and development of diseases of the endocrine, nervous, digestive, musculosk…
The functional roles of the circRNA/Wnt axis in cancer Open
CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the developmen…
Oxidative Injury in Ischemic Stroke: A Focus on NADPH Oxidase 4 Open
Ischemic stroke is a leading cause of disability and mortality worldwide. Thus, it is urgent to explore its pathophysiological mechanisms and find new therapeutic strategies for its successful treatment. The relationship between oxidative …
Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression Open
Circular RNAs (circRNAs), covalently closed noncoding RNAs, are widely expressed in eukaryotes and viruses. They can function by regulating target gene expression, linear RNA transcription and protein generation. The phosphoinositide 3-kin…
Metabolic Signature-Based Subtypes May Pave Novel Ways for Low-Grade Glioma Prognosis and Therapy Open
Metabolic signatures are frequently observed in cancer and are starting to be recognized as important regulators for tumor progression and therapy. Because metabolism genes are involved in tumor initiation and progression, little is known …
Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers Open
The dysregulation of mRNA translation is common in malignancies and may lead to tumorigenesis and progression. Eukaryotic initiation factor 4A (eIF4A) proteins are essential for translation, exhibit bidirectional RNA helicase function, and…
Inflammation and Oxidative Stress: Potential Targets for Improving Prognosis After Subarachnoid Hemorrhage Open
Subarachnoid hemorrhage (SAH) has a high mortality rate and causes long-term disability in many patients, often associated with cognitive impairment. However, the pathogenesis of delayed brain dysfunction after SAH is not fully understood.…
Multi-Omic Analyses of the m5C Regulator ALYREF Reveal Its Essential Roles in Hepatocellular Carcinoma Open
The ALYREF protein acts as a crucial epigenetic regulator in several cancers. However, the specific expression levels and functional roles of ALYREF in cancers are largely unknown, including for hepatocellular carcinoma (HCC). In a pan-can…
Foxo1‐induced miR‐92b down‐regulation promotes blood‐brain barrier damage after ischaemic stroke by targeting NOX4 Open
The blood‐brain barrier (BBB) damage is a momentous pathological process of ischaemic stroke. NADPH oxidases 4 (NOX4) boosts BBB damage after ischaemic stroke and its expression can be influenced by microRNAs. This study aimed to probe int…
Long noncoding RNA GAS8-AS1: A novel biomarker in human diseases Open
Long non-coding RNAs (lncRNAs) represent a group of ncRNAs with more than 200 nucleotides. These RNAs can specifically regulate gene expression at both the transcriptional and the post-transcriptional levels, and increasing evidence indica…
Novel insights for lncRNA MAGI2-AS3 in solid tumors Open
Long non-coding RNAs (lncRNAs) refer to elements of genomic transcription with more than 200 nucleotides that are not translated into proteins, but have crucial roles in cancer progression. MAGI2-AS3, a novel lncRNA, has been reported to b…
Mitochondrial Mechanisms of Necroptosis in Liver Diseases Open
Cell death represents a basic biological paradigm that governs outcomes and long-term sequelae in almost every hepatic disease. Necroptosis is a common form of programmed cell death in the liver. Necroptosis can be activated by ligands of …