Ganyi Chen
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View article: The role of CARMA3 in regulating fibrosis to prevent hypertrophic cardiomyopathy
The role of CARMA3 in regulating fibrosis to prevent hypertrophic cardiomyopathy Open
Hypertrophic cardiomyopathy (HCM) is characterized by cardiac hypertrophy and fibrosis. To investigate the impact of CARMA3 on fibroblast phenotypic transformation in hypertrophic cardiomyopathy (HCM), the correlation between CARMA3 expres…
View article: Giant cardiac tumor resection combined with left ventricular reconstruction
Giant cardiac tumor resection combined with left ventricular reconstruction Open
Reports of large tumors of the left ventricle are rare. In this instance, we present a situation where a 57-year-old woman underwent surgical intervention for a sizable mass in her left ventricle. The mass was attached to the walls of the …
View article: Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction
Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction Open
Ischemic heart disease (IHD) remains a leading cause of mortalities worldwide, necessitating timely reperfusion to reduce acute mortality. Paradoxically, reperfusion can induce myocardial ischemia/reperfusion (I/R) injury, which is primari…
View article: IKKɑ prevents acute kidney injury after cardiac surgery via promoting efferocytosis and inhibiting pyrocytosis
IKKɑ prevents acute kidney injury after cardiac surgery via promoting efferocytosis and inhibiting pyrocytosis Open
Macrophage-dependent microenvironmental changes orchestrate many features of the immune response during inflammation from cardiac surgery-associated acute kidney injury (CSA-AKI). IκB kinase α (also known as IKKα) is a key transcriptional …
View article: Macrophage, a potential targeted therapeutic immune cell for cardiomyopathy
Macrophage, a potential targeted therapeutic immune cell for cardiomyopathy Open
Cardiomyopathy is a major cause of heart failure, leading to systolic and diastolic dysfunction and promoting adverse cardiac remodeling. Macrophages, as key immune cells of the heart, play a crucial role in inflammation and fibrosis. More…
View article: I-κB kinase-ε deficiency improves doxorubicin-induced dilated cardiomyopathy by inhibiting the NF-κB pathway
I-κB kinase-ε deficiency improves doxorubicin-induced dilated cardiomyopathy by inhibiting the NF-κB pathway Open
Dilated cardiomyopathy (DCM) can lead to heart expansion and severe heart failure, but its specific pathogenesis is still elusive. In many cardiovascular diseases, I-κB kinase-ε (IKKε) has been recognized as a pro-inflammatory molecule. In…
View article: I-κB kinase-ε deficiency attenuates the development of Doxorubicin-induced dilated cardiomyopathy
I-κB kinase-ε deficiency attenuates the development of Doxorubicin-induced dilated cardiomyopathy Open
Dilated cardiomyopathy (DCM) can lead to heart expansion and severe heart failure, but its specific pathogenesis is still elusive. In many cardiovascular diseases, I-κB kinase-ε (IKKε) has been recognized as a pro-inflammatory molecule. In…
View article: MiR-937-3p Promotes Metastasis and Angiogenesis and is Activated by MYC in Lung Adenocarcinoma
MiR-937-3p Promotes Metastasis and Angiogenesis and is Activated by MYC in Lung Adenocarcinoma Open
Background : Non-small cell lung cancer (NSCLC) is still one of the diseases with the highest mortality and morbidity, and lung adenocarcinoma (LUAD) is the majority of NSCLC. miRNA can be used as a potential biological marker and treatmen…
View article: IKKε knockout alleviates angiotensin II‑induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway
IKKε knockout alleviates angiotensin II‑induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway Open
Inhibitor of nuclear factor-κB kinase subunit ε (IKKε) is an important signal regulator in the formation of abdominal aortic aneurysm (AAA). However, the underlying mechanism remains to be elucidated. Therefore, the present study aimed to …
View article: Upregulation of Cartilage Oligomeric Matrix Protein and Bone Morphogenetic Protein-2 May Associate with Calcific Aortic Valve Disease
Upregulation of Cartilage Oligomeric Matrix Protein and Bone Morphogenetic Protein-2 May Associate with Calcific Aortic Valve Disease Open
Objective: Calcific aortic valve disease (CAVD) affects millions of elderly people, and there is currently no effective way to stop or slow down its progression. Therefore, exploring the pathogenesis of CAVD is very important for preventio…
View article: I‐<i>κ</i>B Kinase‐<i>ε</i> Deficiency Attenuates the Development of Angiotensin II‐Induced Myocardial Hypertrophy in Mice
I‐<i>κ</i>B Kinase‐<i>ε</i> Deficiency Attenuates the Development of Angiotensin II‐Induced Myocardial Hypertrophy in Mice Open
I‐ κ B kinase‐ ε (IKK ε ) is a member of the IKK complex and a proinflammatory regulator that is active in many diseases. Angiotensin II (Ang II) is a vasoconstricting peptide hormone, and Ang II‐induced myocardial hypertrophy is a common …