Explanipedia

Production of triacetic acid lactone from oleic acid by engineering the yeast Candida viswanathii Open

Saptarshi Ghosh, Alex H. Hutagalung, Yuqian Gao, Javier E. Flores, Yichao Han , et al. · 2025

Triacetic acid lactone (TAL) is a promising platform chemical to produce valuable compounds. The development of engineered microbial hosts to efficiently produce TAL from lipid-containing waste streams could be a cost-effective, sustainabl…

Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization Open

Jeffrey J. Czajka, Ziyu Dai, Tijana Radivojević, Joonhoon Kim, Shuang Deng , et al. · 2025

Complement Proteins Identify Rapidly Progressive Diabetic Kidney Disease Open

Donghwan Yun, S. C. Bae, Yuqian Gao, Lauren Lopez, Dohyun Han , et al. · 2025

The strong association between complement activation and rapid DKD progression highlights the need to explore complement inhibition as a potential therapeutic strategy for DKD.

Enhanced chemotaxis and degradation of nonylphenol in Pseudoxanthomonas mexicana via CRISPR-mediated receptor modification Open

Ran Chai, Jiaxiang Guo, Chuanzhong Yang, Dan Zhu, Tao Li , et al. · 2025

Optimal Selection and Experimental Verification of Wide-Bandgap Semiconductor for Betavoltaic Battery Open

Zhang Jiachen, Ke Lv, Yuan Yin, Yuqian Gao, Ye Tian , et al. · 2025

Wide-bandgap semiconductor betavoltaic batteries have a promising prospect in Micro-Electro-Mechanical Systems for high power density and long working life, but their material selection is still controversial. Specifically, the silicon car…

Miiyuu/scAgent: Universal Cell Type Annotation via a LLM Open

Peigen Liu, Mengfei Zhang, Hanqing Liu, Yuqian Gao · 2025

This is the LoRA-MoE plugins tools of scAgent.

PeakDecoder enables machine learning-based metabolite annotation and accurate profiling in multidimensional mass spectrometry measurements Open

Aivett Bilbao Pena, Joonhoon Kim, Danny Orton, Yuqian Gao, Kunal Poorey , et al. · 2025

The oleaginous yeast Rhodosporidium toruloides engineered for biomass hydrolysate-derived (E)-α-bisabolene production Open

Paul Adamczyk, Hee Jin Hwang, Tso-Cheng Chang, Yuqian Gao, Edward E.K. Baidoo , et al. · 2025

The oleaginous yeast Rhodosporidiumtoruloides has been exploited for many bioproducts, including several terpenes, owing to its oleaginous nature and biomass inhibitor tolerance. Here, we built upon previous (E)-α-bisabolene work by iterat…

Advanced multi-modal mass spectrometry imaging reveals functional differences of placental villous compartments at microscale resolution Open

Marija Veličković, Leena Kadam, Joonhoon Kim, Kevin Zemaitis, Dušan Veličković , et al. · 2025

The Mechanism of Ammonia-Assimilating Bacteria Promoting the Growth of Oyster Mushrooms (Pleurotus ostreatus) Open

Rui Li, Qi Zhang, Yuannan Chen, Yuqian Gao, Yanqing Yang , et al. · 2025

Oyster mushrooms (Pleurotus ostreatus) are one of the most commonly grown edible mushrooms using compost, which contains high concentrations of ammonia. In this study, inoculation of the oyster mushroom culture substrate with ammonia-assim…

Data for EMSL Project 51637 from January 2024 Open

Ellen Panisko, Scott Baker, Scott Baker, Errol Robinson, Jon Magnuson , et al. · 2025

The Impact of Fabrication Processes on the Performance of Betavoltaic Battery Open

Jiachen Zhang, Yuqian Gao, Ke Lv, Jiacheng Li, Yuncheng Han , et al. · 2025

Construction of a Tertiary Lymphoid Structure Gene Signature in Gastric Cancer and Its Predictive Value for the Tumor Microenvironment and Immunotherapy Open

Yunqi Hua, Xiaoling Tian, Yanhong Liu, Yuqian Gao, Fangrui Yin · 2025

This study aimed to investigate the impact of tertiary-lymphoid-structure-related genes on the clinical prognosis and tumor immune environment of patients with gastric cancer. Using The Cancer Genome Atlas data, 23 differentially expressed…

Ammonia-Assimilating Bacteria Promote Wheat (Triticum aestivum) Growth and Nitrogen Utilization Open

Yuqian Gao, Qi Zhang, Yuannan Chen, Yanqing Yang, Chenxiao Zhou , et al. · 2024

Nitrogen fertilizers in agriculture often suffer losses. Ammonia-assimilating bacteria can immobilize ammonia and reduce these losses, but they have not been used in agriculture. This study identified an ammonia-assimilating strain, Entero…

Flg22‐facilitated <span>PGPR</span> colonization in root tips and control of root rot Open

Yanan Li, Yafei Li, Yuepeng Wang, Yanqing Yang, Man Qi , et al. · 2024

Plant root border cells (RBCs) prevent the colonization of plant growth‐promoting rhizobacteria (PGPR) at the root tip, rendering the PGPR unable to effectively control pathogens infecting the root tip. In this study, we engineered four st…

Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach Open

Sneha Couvillion, Ernesto Nakayasu, Bobbie‐Jo Webb‐Robertson, Isabella H. Yang, Josie Eder , et al. · 2024

Applications and challenges of photodynamic therapy in the treatment of skin malignancies Open

Yunqi Hua, Xiaoling Tian, Xinyi Zhang, Ge Song, Yubo Liu , et al. · 2024

Photodynamic Therapy (PDT), as a minimally invasive treatment method, has demonstrated its distinct advantages in the management of skin malignant tumors. This article examines the current application status of PDT, assesses its successful…

Urine complement proteins are associated with kidney disease progression of type 2 diabetes in Korean and American cohorts Open

Donghwan Yun, S. C. Bae, Yuqian Gao, Lauren Lopez, Dohyun Han , et al. · 2024

Background Mechanisms of progression of diabetic kidney disease (DKD) are not completely understood. This study uses untargeted and targeted mass spectrometry-based proteomics in two independent cohorts on two continents to decipher the me…

Unveiling preferred chemoattractants for rhizosphere PGPR colonization by molecular docking and molecular dynamics simulations Open

Ran Chai, Fuxin Li, Yuqian Gao, Dehai Liu, Di Shang , et al. · 2024

Unveiling the preferred chemoattractants of plant growth-promoting rhizobacteria (PGPR) toward the rhizosphere is crucial for engineering PGPR to improve their chemotactic rhizocompetence. Here, we selected 59 common components of root exu…

PeakQC: A Software Tool for Omics-Agnostic Automated Quality Control of Mass Spectrometry Data Open

Andrea Harrison, Josie Eder, Priscila M. Lalli, Nathalie Munoz Munoz, Yuqian Gao , et al. · 2024

Mass spectrometry is broadly employed to study complex molecular mechanisms in various biological and environmental fields, enabling 'omics' research such as proteomics, metabolomics, and lipidomics. As study cohorts grow larger and more c…

Multi-scale signaling and tumor evolution in high-grade gliomas Open

Jingxian Liu, Song Cao, Kathleen J. Imbach, Marina Gritsenko, T. Mamie Lih , et al. · 2024

Evaluation of a Reference-Free Collision Cross Section Calibration Strategy for Proteomics Using SLIM-Based High-Resolution Ion Mobility Spectrometry–Mass Spectrometry Open

Dylan H. Ross, Jung Yun Lee, Yuqian Gao, Adam Hollerbach, Aivett Bilbao Pena , et al. · 2024

Ion mobility spectrometry (IMS) is a gas-phase analytical technique that separates ions with different sizes and shapes and is compatible with mass spectrometry (MS) to provide an additional separation dimension. The rapid nature of the IM…

Data for EMSL Project 48666 from July 2020 Open

Karin Rodland, Anil Shukla, Richard Smith, David Camp, Rui Zhao , et al. · 2024

Data for EMSL Project 48666 from June 2019 Open

Karin Rodland, Anil Shukla, Richard Smith, David Camp, Rui Zhao , et al. · 2024

Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach Open

Sneha Couvillion, Ernesto Nakayasu, Bobbie‐Jo Webb‐Robertson, I. L. Yang, Josie Eder , et al. · 2024

The risk of contracting SARS-CoV-2 via human milk-feeding is virtually non-existent. Adverse effects of COVID-19 vaccination for lactating individuals are not different from the general population, and no evidence has been found that their…

Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium Open

Marija Veličković, Ruonan Wu, Yuqian Gao, Margaret W. Thairu, Dušan Veličković , et al. · 2024

The annotated protein database was curated to annotate MS/MS data in the manuscript titled 'Mapping Microhabitats: Metabolome Informed Proteome Imaging of Lignocellulose Decomposition by a Naturally Evolved Microbial Consortium'.

QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE Open

Jinfang Dou, Xin'ai Zhang, Chaoqun Hu, Yuqian Gao, Yue Zhao , et al. · 2024

The onset of Alzheimer's disease is related to neuron damage caused by massive deposition of Aβ in the brain. Recent studies suggest that excessive Aβ in the brain mainly comes from peripheral blood, and BBB is the key to regulate Aβ in an…

Mapping microhabitats of lignocellulose decomposition by a microbial consortium Open

Marija Veličković, Ruonan Wu, Yuqian Gao, Margaret W. Thairu, Dušan Veličković , et al. · 2024

The leaf-cutter ant fungal garden ecosystem is a naturally evolved model system for efficient plant biomass degradation. Degradation processes mediated by the symbiotic fungus Leucoagaricus gongylophorus are difficult to characterize due t…

Modeling and measurement of a miniature piezoelectric ceramic tube fiber scanner for two-photon endomicroscopy Open

Conghao Wang, Huilan Liu, Junjie Wang, Qiang Fu, Yanhui Hu , et al. · 2024

To enable optical biopsy in clinical applications, it is essential to miniaturize fiber-optic two-photon endomicroscopy (TPEM). This study used theoretical modeling and experimental measurements on a 1-mm-outer-diameter piezoelectric ceram…

Comparative efficacy of different Chinese patent medicines in preventing restenosis after percutaneous coronary intervention: a systematic review and Bayesian network meta-analysis of randomized clinical trials Open

Jiasai Fan, Tianli Li, Fenglan Pu, Nan Guo, Jing Wang , et al. · 2024

Background: Chinese patent medicines (CMPs) have curative effectiveness in preventing coronary restenosis. However, the relative efficacy between different CPMs has not been sufficiently investigated. Methods: Randomized clinical trials we…

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