Yulong Gao
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View article: The mutated very virulent IBDV (mvvIBDV) suppresses immune responses to avian influenza and newcastle disease immunization
The mutated very virulent IBDV (mvvIBDV) suppresses immune responses to avian influenza and newcastle disease immunization Open
View article: Melatonin enhanced photosynthesis efficiency by improving carotenoid biosynthesis and carbon fixation via regulation of transcription factors
Melatonin enhanced photosynthesis efficiency by improving carotenoid biosynthesis and carbon fixation via regulation of transcription factors Open
View article: A recombinant Marek’s disease vaccine candidate provides complete protection against infectious bursal disease virus and H9 subtype avian influenza virus in chickens
A recombinant Marek’s disease vaccine candidate provides complete protection against infectious bursal disease virus and H9 subtype avian influenza virus in chickens Open
Vaccination is the most effective preventative measure against economically devastating poultry diseases, such as infectious bursal disease (IBD), H9 subtype avian influenza (AI), and Marek’s disease. In recent decades, various vaccination…
View article: Chicken NLRP3 monoclonal antibody development and its antigenic epitope identification
Chicken NLRP3 monoclonal antibody development and its antigenic epitope identification Open
View article: Development and Application of Indirect ELISA for IBDV VP2 Antibodies Detection in Poultry
Development and Application of Indirect ELISA for IBDV VP2 Antibodies Detection in Poultry Open
Infectious bursal disease virus (IBDV) is one of the most important immunosuppressive viruses in poultry, causing the global spread of infectious bursal disease (IBD). It poses a significant threat to the healthy development of the poultry…
View article: LOX5 roles in forming diverse aroma profiles of Nicotiana tabacum via multi-omics analysis
LOX5 roles in forming diverse aroma profiles of Nicotiana tabacum via multi-omics analysis Open
View article: Epidemiological characteristics of infectious bursal disease virus (IBDV) in China from 2023 to 2024: Mutated very virulent IBDV (mvvIBDV) is associated with atypical IBD
Epidemiological characteristics of infectious bursal disease virus (IBDV) in China from 2023 to 2024: Mutated very virulent IBDV (mvvIBDV) is associated with atypical IBD Open
View article: N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling
N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling Open
Subgroup J avian leukosis virus (ALV-J), a retrovirus, elicits immunosuppression and persistent infections in chickens. Although it is widely acknowledged that ALV-J can evade the host’s innate immune defenses, the mechanisms behind this i…
View article: Enhancing MyD88 oligomerization is one important mechanism by which IBDV VP2 induces inflammatory response
Enhancing MyD88 oligomerization is one important mechanism by which IBDV VP2 induces inflammatory response Open
The inflammatory response is an essential component of innate immunity to defense against pathogens. Infectious bursal disease (IBD) is the most important immunosuppressive disease in chickens and is caused by the infectious bursal disease…
View article: Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB
Marek’s disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB Open
Marek’s disease virus (MDV) is an avian alphaherpesvirus associated with Marek’s disease, an immunosuppressive and lymphoproliferative disease in chickens. The DNA sensing pathway mediates innate immune defense against infection by many DN…
View article: Monoclonal antibody development and antigenic epitope identification of chicken pro-IL-1β
Monoclonal antibody development and antigenic epitope identification of chicken pro-IL-1β Open
View article: Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus
Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus Open
Chicken infectious anemia (CIA) is a highly contagious disease caused by the chicken infectious anemia virus (CIAV), and it poses a serious threat to the poultry industry. However, effective control measures and strategies have not been id…
View article: Volatile Profiles of Different Tobacco Cultivars and their Correlation with Sensory Quality of Heated Tobacco
Volatile Profiles of Different Tobacco Cultivars and their Correlation with Sensory Quality of Heated Tobacco Open
Introduction: Different types of tobacco cultivars have been used as raw material in heated tobacco to maximize the sensory richness. However, the volatile profiles of different tobacco cultivars and their correlation with the sensory qual…
View article: Influence of green finance on agricultural green total factor productivity: a case study in China
Influence of green finance on agricultural green total factor productivity: a case study in China Open
With the widespread promotion of the concept of green development, China’s green credit policy system has been established, developed, and gradually improved during the past decade. Against the background of the country’s vigorous developm…
View article: Wet-spun Ag/PEDOT: PSS composite fibers for high-sensitive SERS sensing and high electrical conducting
Wet-spun Ag/PEDOT: PSS composite fibers for high-sensitive SERS sensing and high electrical conducting Open
Nanometal-based composite fibers have been widely explored in flexible sensors due to their outstanding optical and electrical properties. However, the weak binding force between metallic nanomaterial and fiber greatly limits the real appl…
View article: Marek’s disease virus inhibits the JAK-STAT signaling pathway to evade the innate immune response1
Marek’s disease virus inhibits the JAK-STAT signaling pathway to evade the innate immune response1 Open
View article: Identification of Cables1 as a critical host factor that promotes ALV-J replication via genome-wide CRISPR/Cas9 gene knockout screening
Identification of Cables1 as a critical host factor that promotes ALV-J replication via genome-wide CRISPR/Cas9 gene knockout screening Open
Avian leukosis virus subgroup J (ALV-J), a member of the genus Alpharetrovirus, possesses a small genome and exploits a vast array of host factors during its replication cycle. To identify host factors required for ALV-J replication and po…
View article: Construction of Recombinant Marek’s Disease Virus Co-Expressing VP1 and VP2 of Chicken Infectious Anemia Virus
Construction of Recombinant Marek’s Disease Virus Co-Expressing VP1 and VP2 of Chicken Infectious Anemia Virus Open
The chicken infectious anemia virus (CIAV) has been reported in major poultry-producing countries and poses a significant threat to the poultry industry worldwide. In this study, two Marek’s disease virus (MDV) recombinants, rMDV-CIAV-1 an…
View article: Construction of recombinant Marek’s disease virus co-expressing σB and σC of avian reoviruses
Construction of recombinant Marek’s disease virus co-expressing σB and σC of avian reoviruses Open
Avian reoviruses (ARVs) cause viral arthritis or tenosynovitis, resulting in poor weight gain and increased feed conversion ratios in chickens. In this study, we generated three Marek’s disease virus (MDV) recombinants, namely, rMDV-ARV-σB…
View article: Specific and Sensitive Visual Proviral DNA Detection of Major Pathogenic Avian Leukosis Virus Subgroups Using CRISPR-Associated Nuclease Cas13a
Specific and Sensitive Visual Proviral DNA Detection of Major Pathogenic Avian Leukosis Virus Subgroups Using CRISPR-Associated Nuclease Cas13a Open
Avian leukosis viruses (ALVs) include a group of avian retroviruses primarily associated with neoplastic diseases in poultry, commonly referred to as avian leukosis. Belonging to different subgroups based on their envelope properties, ALV …
View article: Ligilactobacillus salivarius XP132 with antibacterial and immunomodulatory activities inhibits horizontal and vertical transmission of Salmonella Pullorum in chickens
Ligilactobacillus salivarius XP132 with antibacterial and immunomodulatory activities inhibits horizontal and vertical transmission of Salmonella Pullorum in chickens Open
Probiotics are increasingly recognized for their capacity to combat pathogenic bacteria. In this study, we isolated a strain of Ligilactobacillus salivarius XP132 from the gut microbiota of healthy chickens. This strain exhibited resistanc…
View article: New domain decomposition algorithm for convection-dominated diffusion equations with the Samarskii scheme and the Jacobi explicit scheme
New domain decomposition algorithm for convection-dominated diffusion equations with the Samarskii scheme and the Jacobi explicit scheme Open
A new algorithm for convection-dominated diffusion equations is proposed. Based on the domain decomposition method (DDM), the algorithm integrates the Samarskii scheme and the Jacobi explicit scheme with explicit/implicit coupling to provi…
View article: Investigating the spatiotemporal expression of CBTS genes lead to the discovery of tobacco root as a cembranoid-producing organ
Investigating the spatiotemporal expression of CBTS genes lead to the discovery of tobacco root as a cembranoid-producing organ Open
Tobacco cembranoids, known for their anti-insect and antifungal properties, were shown to be mainly present on the surface of leaves and flowers, being biosynthesized by their trichomes. It remains unclear whether they could be biosynthesi…
View article: A tonoplast-localized TPK-type K+ transporter (TPKa) regulates potassium accumulation in tobacco
A tonoplast-localized TPK-type K+ transporter (TPKa) regulates potassium accumulation in tobacco Open
Potassium ion (K+) is one of the most essential nutrients for the growth and development of tobacco (Nicotiana tabacum L.), however, the molecular regulation of K+ concentration in tobacco remains unclear. In this stu…
View article: Advances on ALV-J in China over the past two decades
Advances on ALV-J in China over the past two decades Open
Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus (ALV) in poultry. ALVs belong to the retroviral family and are classified into 11 subgroups (ALV-A to ALV-K). Among them, ALV-J was first introduced into…
View article: OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway
OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway Open
Infectious bursal disease (IBD) is an acute and fatal immunosuppressive disease caused by infectious bursal disease virus (IBDV). As an obligate intracellular parasite, IBDV infection is strictly regulated by host factors. Knowledge on the…
View article: Development of an improved reverse genetics system for avian metapneumovirus (aMPV): A novel vaccine vector protects against aMPV and infectious bursal disease virus
Development of an improved reverse genetics system for avian metapneumovirus (aMPV): A novel vaccine vector protects against aMPV and infectious bursal disease virus Open
Avian metapneumovirus (aMPV), a paramyxovirus, causes acute respiratory diseases in turkeys and swollen head syndrome in chickens. This study established a reverse genetics system for aMPV subtype B LN16-A strain based on T7 RNA polymerase…
View article: Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell
Author Correction: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cell Open
View article: N123I mutation in the ALV-J receptor-binding domain region enhances viral replication ability by increasing the binding affinity with chNHE1
N123I mutation in the ALV-J receptor-binding domain region enhances viral replication ability by increasing the binding affinity with chNHE1 Open
The subgroup J avian leukosis virus (ALV-J), a retrovirus, uses its gp85 protein to bind to the receptor, the chicken sodium hydrogen exchanger isoform 1 (chNHE1), facilitating viral invasion. ALV-J is the main epidemic subgroup and shows …
View article: Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner
Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner Open
Viruses have evolved intricate mechanisms to evade host antiviral responses and exploit cellular resources by manipulating the expression profile of host genes. During infection, viruses encode proteins with shutoff activity to globally in…