Gang Jin
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View article: The triad of maternal gut-breast milk-infant gut microbial transmission in early life as a critical pathway for microbial inheritance
The triad of maternal gut-breast milk-infant gut microbial transmission in early life as a critical pathway for microbial inheritance Open
Although maternal microbial inheritance is recognized, the temporal dynamics of how the maternal gut microbiota shapes the infant gut microbiota via specific routes remain unexplored. We performed longitudinal, multi-site microbiota sampli…
View article: ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer
ODFormer: a Virtual Organoid for Predicting Personalized Therapeutic Responses in Pancreatic Cancer Open
Pancreatic cancer (PC) patient-derived organoids (PDOs) faithfully recapitulate therapeutic responses but face clinical translation barriers, including high costs and technical complexity. To address these problems and the lack of framewor…
View article: GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing
GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing Open
ClinicalTrials.gov identifier: NCT05431621.
View article: Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration
Expert consensus on the diagnosis and treatment of non-small cell lung cancer with MET alteration Open
Alterations in the mesenchymal-epithelial transition factor (MET) gene are critical drivers of non-small cell lung cancer (NSCLC). In recent years advances in precision therapies targeting MET alterations have significantly expanded treatm…
View article: A large-scale prospective nested case-control study: developing a comprehensive risk prediction model for early detection of pancreatic cancer in the community-based ESPRIT-AI cohort
A large-scale prospective nested case-control study: developing a comprehensive risk prediction model for early detection of pancreatic cancer in the community-based ESPRIT-AI cohort Open
Background: Pancreatic cancer (PC) remains a significant public health concern due to its late diagnosis and limited effective screening methods. This study aimed to develop a robust risk prediction model for early detection, utilizing a l…
View article: Magnetic Nanocarriers for pH/GSH/NIR Triple-Responsive Drug Release and Synergistic Therapy in Tumor Cells
Magnetic Nanocarriers for pH/GSH/NIR Triple-Responsive Drug Release and Synergistic Therapy in Tumor Cells Open
In this study, the mesoporous Fe3O4 nanodrug carriers containing disulfide bonds (CHO-SMNPs) were successfully synthesized and characterized. Doxorubicin (DOX) was loaded onto the CHO-SMNPs as a model drug and gatekeeper through the format…
View article: Physicochemical Properties, Drug Release and In Situ Depot-Forming Behaviors of Alginate Hydrogel Containing Poorly Water-Soluble Aripiprazole
Physicochemical Properties, Drug Release and In Situ Depot-Forming Behaviors of Alginate Hydrogel Containing Poorly Water-Soluble Aripiprazole Open
The objective of this study was to investigate the physicochemical properties, drug release and in situ depot-forming behavior of alginate hydrogel containing poorly water-soluble aripiprazole (ARP) for achieving free-flowing injectability…
View article: Research on grinding parameter optimization based on adhesive semiconductor quartz disc
Research on grinding parameter optimization based on adhesive semiconductor quartz disc Open
To study the influence of grinding parameters on the grinding force of semiconductor quartz disc based on the adhesive clamping method, an orthogonal experiment was designed to investigate the impact of grinding parameters on the grinding …
View article: GSH-responsive magnetic mesoporous silica nanoparticles for efficient controlled drug delivery in tumor cells
GSH-responsive magnetic mesoporous silica nanoparticles for efficient controlled drug delivery in tumor cells Open
In this study, glutathione (GSH)-responsive magnetic mesoporous silica nanoparticles grafted by disulfide organosilicon (SMNPs) were synthesized, characterized, and evaluated as controlled drug carriers. The nanoparticles exhibited consist…
View article: Functional characterization of malate dehydrogenase, HcMDH1, gene in enhancing abiotic stress tolerance in kenaf (Hibiscus cannabinus L.)
Functional characterization of malate dehydrogenase, HcMDH1, gene in enhancing abiotic stress tolerance in kenaf (Hibiscus cannabinus L.) Open
Drought and salt stress are two important environmental factors that significantly restrict plant growth and reproduction. Malate dehydrogenase is essential to life as it is engaged in numerous physiological processes in cells, particularl…
View article: CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis
CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis Open
Diabetic nephropathy (DN) is one of microvascular complication associated with diabetes. Circular RNAs (circRNAs) have been shown to be involved in DN pathogenesis. Hence, this work aimed to explore the role and mechanism of circ_Arf3 in D…
View article: Functional characterization of malate dehydrogenase gene, HcMDH1 in enhancing abiotic stress tolerance in kenaf (Hibiscus cannabinus L.)
Functional characterization of malate dehydrogenase gene, HcMDH1 in enhancing abiotic stress tolerance in kenaf (Hibiscus cannabinus L.) Open
Drought and salt stress are two important environmental factors that significantly restrict plant growth and production. Malate dehydrogenase is essential to life as it is engaged in numerous physiological processes in cells, particularly …
View article: The cost of total hip arthroplasty: compare the hospitalization costs of national centralized procurement and national volume-based procurement
The cost of total hip arthroplasty: compare the hospitalization costs of national centralized procurement and national volume-based procurement Open
Background With the increasing demand for joint replacement surgery in China, the government has successively issued the policies of national centralized procurement (NCP) and national volume-based procurement (NVBP) of artificial joints. …
View article: A multi-omics technology to the study of lactic acid bacteria responses to environmental stress: the past, current and future trends
A multi-omics technology to the study of lactic acid bacteria responses to environmental stress: the past, current and future trends Open
Lactic acid bacteria and the fermentation environment interact to form an intertwined system. Lactic acid bacteria are constantly evolving to adapt to different fermentation environments, causing changes in their physiological processes. T…
View article: Limitations and Innovative Application Methods of Surfactants for Solubilization of Poorly Water-Soluble Drugs
Limitations and Innovative Application Methods of Surfactants for Solubilization of Poorly Water-Soluble Drugs Open
Poor solubility of drugs leads to poor bioavailability and therapeutic efficiency. A large proportion of drugs that are not developed and marketed for use by patients are due to their extremely low solubility. Therefore, improving the solu…
View article: Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics
Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics Open
Background Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers. The aim of this study is…
View article: Pore structure characteristics of coral reef limestone: a combined polarizing microscope and CT scanning study
Pore structure characteristics of coral reef limestone: a combined polarizing microscope and CT scanning study Open
Coral reef limestone is a special class of geological medium formed through long-term deposition following the death of reef-building coral groups. Because it retains the skeletal structure of marine organisms during its formation, its por…
View article: Semisupervised 3D segmentation of pancreatic tumors in positron emission tomography/computed tomography images using a mutual information minimization and cross-fusion strategy
Semisupervised 3D segmentation of pancreatic tumors in positron emission tomography/computed tomography images using a mutual information minimization and cross-fusion strategy Open
The experimental results demonstrate the superiority of our MIM-CMFNet over existing semisupervised techniques. Our approach can achieve a performance similar to that of fully supervised segmentation methods while significantly reducing th…
View article: Study on the control method of flatness of thin-walled parts milled from 7075 aluminum alloy based on ice-fixation
Study on the control method of flatness of thin-walled parts milled from 7075 aluminum alloy based on ice-fixation Open
Investigation of a new process and method to control the planarity of thin-walled parts can provide an important theoretical and application foundation for the high-precision, high-quality fabrication of thin-walled components in aerospace…
View article: Supplementary Figure 5 from Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells Producing IL15 Eradicate Established Pancreatic Tumor in Syngeneic Mice
Supplementary Figure 5 from Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells Producing IL15 Eradicate Established Pancreatic Tumor in Syngeneic Mice Open
PDF - 115K, (A) Intratumor infiltration of CD4+FoxP3+ regulatory T cells were determined by flow cytometry at 10 days after MSC-IL-15 injection. (B) mRNA levels of Foxp3 in tumor tissue were detected by qRT-PCR. (C) MSC-GFP with tumor cell…
View article: Supplementary Figure 1 from Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells Producing IL15 Eradicate Established Pancreatic Tumor in Syngeneic Mice
Supplementary Figure 1 from Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells Producing IL15 Eradicate Established Pancreatic Tumor in Syngeneic Mice Open
PDF - 71K, The expression of immunologic markers on MSC surface by FACS analysis of CD14, CD11b, and CD16 expressions.