Gareth Cross
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View article: Genome-resolved metagenomics uncovers antimicrobial resistance gene carriers in hospital and municipal wastewater environments
Genome-resolved metagenomics uncovers antimicrobial resistance gene carriers in hospital and municipal wastewater environments Open
Wastewater-based epidemiology (WBE) is a powerful approach to study antimicrobial resistance (AMR) dynamics at the population level. Using genome-resolved metagenomics, we recovered 3978 metagenome-assembled genomes (MAGs) from archived me…
View article: Predicting norovirus contamination and antimicrobial resistance in coastal waters from community and hospital-derived sources
Predicting norovirus contamination and antimicrobial resistance in coastal waters from community and hospital-derived sources Open
Hospital-derived wastewater can enter the aquatic environment, posing a serious risk to public health due to the presence of pathogenic viruses and antimicrobial resistant (AMR) organisms. A quantitative understanding of the factors affect…
View article: Metagenomic profiling of hospital wastewater: A comprehensive national scale analysis of antimicrobial resistance genes and opportunistic pathogens
Metagenomic profiling of hospital wastewater: A comprehensive national scale analysis of antimicrobial resistance genes and opportunistic pathogens Open
Overall, the study highlights the effectiveness of combining wastewater-based epidemiology with metagenomics to gain critical insights into the distinct resistome and microbiome profiles in hospital settings. Tailored strategies are essent…
View article: Toileting behaviours of the UK public: insights for reducing demographic bias in wastewater-based epidemiology sampling strategies
Toileting behaviours of the UK public: insights for reducing demographic bias in wastewater-based epidemiology sampling strategies Open
Wastewater-based epidemiology has gained increasing interest for its application as a public health surveillance tool, yet the impact of toileting habits over the representativeness of wastewater data remains underexplored. To address this…
View article: High-throughput qPCR profiling of antimicrobial resistance genes and bacterial loads in wastewater and receiving environments
High-throughput qPCR profiling of antimicrobial resistance genes and bacterial loads in wastewater and receiving environments Open
Wastewater treatment plants (WWTPs) are hot spots for the acquisition and spread of antimicrobial resistance (AMR). This regional-based study quantified antibiotic resistance genes (ARGs), mobile genetic elements (MGEs), and bacteria in ho…
View article: Metagenomics unveils the role of hospitals and wastewater treatment plants on the environmental burden of antibiotic resistance genes and opportunistic pathogens
Metagenomics unveils the role of hospitals and wastewater treatment plants on the environmental burden of antibiotic resistance genes and opportunistic pathogens Open
Antimicrobial resistance (AMR) is a global health challenge, with hospitals and wastewater treatment plants (WWTPs) serving as significant pathways for the dissemination of antibiotic resistance genes (ARGs). This study investigates the po…
View article: Implications of long-term sample storage on the recovery of viruses from wastewater and biobanking
Implications of long-term sample storage on the recovery of viruses from wastewater and biobanking Open
Wastewater-based monitoring has been widely implemented worldwide for the tracking of SARS-CoV-2 outbreaks and other viral diseases. In many surveillance programmes, unprocessed and processed wastewater samples are often frozen and stored …
View article: Use of wastewater from passenger ships to assess the movement of COVID-19 and other pathogenic viruses across maritime international boundaries
Use of wastewater from passenger ships to assess the movement of COVID-19 and other pathogenic viruses across maritime international boundaries Open
Objective: The worldwide spread of SARS-CoV-2 and the resulting COVID-19 pandemic has been driven by international travel. This has led to the desire to develop surveillance approaches which can estimate the rate of import of pathogenic or…
View article: Multi-factor normalisation of viral counts from wastewater improves the detection accuracy of viral disease in the community
Multi-factor normalisation of viral counts from wastewater improves the detection accuracy of viral disease in the community Open
The detection of viruses (e.g. SARS-CoV-2, norovirus) in wastewater represents an effective way to monitor the prevalence of these pathogens circulating within the community. However, accurate quantification of viral concentrations in wast…
View article: National-scale antimicrobial resistance surveillance in wastewater: A comparative analysis of HT qPCR and metagenomic approaches
National-scale antimicrobial resistance surveillance in wastewater: A comparative analysis of HT qPCR and metagenomic approaches Open
Wastewater serves as an important reservoir of antimicrobial resistance (AMR), and its surveillance can provide insights into population-level trends in AMR to inform public health policy. This study compared two common high-throughput scr…
View article: Simultaneous detection and characterization of common respiratory pathogens in wastewater through genomic sequencing
Simultaneous detection and characterization of common respiratory pathogens in wastewater through genomic sequencing Open
Genomic surveillance of SARS-CoV-2 has given insight into the evolution and epidemiology of the virus and its variant lineages during the COVID-19 pandemic. Expanding this approach to include a range of respiratory pathogens can better inf…
View article: Comparative assessment of Nanotrap and polyethylene glycol-based virus concentration in wastewater samples
Comparative assessment of Nanotrap and polyethylene glycol-based virus concentration in wastewater samples Open
Wastewater-based epidemiology is now widely used in many countries for the routine monitoring of SARS-CoV-2 and other viruses at a community level. However, efficient sample processing technologies are still under investigation. In this st…
View article: Toileting behaviours of the UK public: insights for reducing gender bias wastewater-based epidemiology sampling strategies
Toileting behaviours of the UK public: insights for reducing gender bias wastewater-based epidemiology sampling strategies Open
Cross-sectional survey results from a toileting behaviour survey conducted between the 27th to the 28th of June 2022. Participants (n = 2109) were aged 18 years or older and were living in the UK. The survey consisted of 17 closed-ended qu…
View article: Toileting behaviours of the UK public: insights for reducing gender bias wastewater-based epidemiology sampling strategies
Toileting behaviours of the UK public: insights for reducing gender bias wastewater-based epidemiology sampling strategies Open
Cross-sectional survey results from a toileting behaviour survey conducted between the 27th to the 28th of June 2022. Participants (n = 2109) were aged 18 years or older and were living in the UK. The survey consisted of 17 closed-ended qu…
View article: Accounting for Dilution of SARS-CoV-2 in Wastewater Samples Using Physico-Chemical Markers
Accounting for Dilution of SARS-CoV-2 in Wastewater Samples Using Physico-Chemical Markers Open
Most sewer networks collect domestic wastewater and a variable proportion of extraneous water, such as rainwater, through surface runoff and industrial discharges. Accounting for wastewater dilution is essential to properly quantify wastew…
View article: Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders
Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders Open
Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underpin gene regulation. Here we demonstrate that variants causing haploinsufficiency of KMTs and KDMs are frequently encountered in individuals with developmental disorders…
View article: Prevalence, phenotype and architecture of developmental disorders caused by<i>de novo</i>mutation: The Deciphering Developmental Disorders Study
Prevalence, phenotype and architecture of developmental disorders caused by<i>de novo</i>mutation: The Deciphering Developmental Disorders Study Open
Individuals with severe, undiagnosed developmental disorders (DDs) are enriched for damaging de novo mutations (DNMs) in developmentally important genes. We exome sequenced 4,293 families with individuals with DDs, and meta-analysed these …