Gareth J. Price
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View article: Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases
Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases Open
Here, we investigate why liver metastases reduce the efficacy of immune checkpoint inhibitors (CPI). The poor prognosis of patients with liver metastases is associated with a systemic increase in neutrophils. Using experimental models, we …
View article: Developing a prospective rapid-learning methodology to evaluate the survival impact of changing radiotherapy practice to include a new heart dose limit for patients with lung cancer in a UK specialist cancer centre (RAPID-RT): a protocol
Developing a prospective rapid-learning methodology to evaluate the survival impact of changing radiotherapy practice to include a new heart dose limit for patients with lung cancer in a UK specialist cancer centre (RAPID-RT): a protocol Open
Introduction The RAPID-RT study is part of a large-scale research programme investigating the use of routinely collected real-world patient data to rapidly and prospectively evaluate and optimise the impact of changes in radiotherapy pract…
View article: An introduction to pragmatic trials in lung cancer research: A multi-faceted approach
An introduction to pragmatic trials in lung cancer research: A multi-faceted approach Open
Pragmatic clinical trials (PTs) are increasingly recognised as a key methodology in lung cancer research, designed to evaluate the effectiveness of interventions in routine clinical settings. In contrast to traditional randomised controlle…
View article: Data, dialogue, and design: patient and public involvement and engagement for natural language processing with real-world cancer data
Data, dialogue, and design: patient and public involvement and engagement for natural language processing with real-world cancer data Open
Introduction This study describes the process and outcomes of a Patient and Public Involvement and Engagement (PPIE) event designed to incorporate patient perspectives into the application of Natural Language Processing (NLP) for analyzing…
View article: Surficial reconstruction in bimetallic oxide SrCoO <sub> <i>x</i> </sub> through Ce-doping for improved corrosion resistance during electrocatalytic oxygen evolution reaction in simulated alkaline saline water
Surficial reconstruction in bimetallic oxide SrCoO <sub> <i>x</i> </sub> through Ce-doping for improved corrosion resistance during electrocatalytic oxygen evolution reaction in simulated alkaline saline water Open
Transition metal based bimetallic oxides are good candidates for electrocatalytic oxygen evolution owing to their variable oxidation states, synergistic effects, good conductivity, convincing electrochemical stability, and low cost. Howeve…
View article: The prognostic significance of sarcopenia in patients treated with definitive radiotherapy: A systematic review
The prognostic significance of sarcopenia in patients treated with definitive radiotherapy: A systematic review Open
Sarcopenia describes the degenerative loss of muscle mass and strength, and is emerging as a pan-cancer prognostic biomarker. It is linked with increased treatment toxicity, decreased survival and significant healthcare financial burden. S…
View article: The effect of polymer end-group on the formation of styrene – maleic acid lipid particles (SMALPs)
The effect of polymer end-group on the formation of styrene – maleic acid lipid particles (SMALPs) Open
Variation in copolymer end groups was found to significantly influence the solution behaviour of styrene maleic acid copolymers. A powerful means to tailor RAFT copolymers towards target membranes could lie with optimised end group chemist…
View article: Distributed learning optimisation of Cox models can leak patient data: Risks and solutions
Distributed learning optimisation of Cox models can leak patient data: Risks and solutions Open
Medical data are often highly sensitive, and frequently there are missing data. Due to the data's sensitive nature, there is an interest in creating modelling methods where the data are kept in each local centre to preserve their privacy, …
View article: The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study
The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study Open
In the presence of external lipids, polymer chains embed throughout lipid membranes, the extent of which is governed by the net membrane charge. Nanodiscs stabilised by three different polymers will all exchange lipids and polymer with mon…
View article: Iodinated Contrast Media Extravasation Injuries: Should Osmolality and the Pattern of Distribution Affect Management?: A Literature Review and Case Report Comparison.
Iodinated Contrast Media Extravasation Injuries: Should Osmolality and the Pattern of Distribution Affect Management?: A Literature Review and Case Report Comparison. Open
A review of the relevant literature suggests that the pattern of distribution should be accounted for when considering surgical management.
View article: Fluorescent styrene maleic acid copolymers to facilitate membrane protein studies in lipid nanodiscs
Fluorescent styrene maleic acid copolymers to facilitate membrane protein studies in lipid nanodiscs Open
Styrene – maleic acid copolymers form lipid nanodiscs that can encapsulate membrane proteins. Introducing fluorescent labels during synthesis provides a new avenue of study into polymer–protein interactions in these systems.
View article: Ab initio reconstruction of small angle scattering data for membrane proteins in copolymer nanodiscs
Ab initio reconstruction of small angle scattering data for membrane proteins in copolymer nanodiscs Open
Small angle scattering techniques can provide structural information on the protein and polymer nanodisc without requiring crystallisation of the protein. Additional complementary techniques, such as ab initio modelling, can generate alter…
View article: Development of Methodology to Investigate the Surface SMALPome of Mammalian Cells
Development of Methodology to Investigate the Surface SMALPome of Mammalian Cells Open
Extraction of membrane proteins from biological membranes has traditionally involved detergents. In the past decade, a new technique has been developed, which uses styrene maleic acid (SMA) copolymers to extract membrane proteins into nano…
View article: Sonochemical production and activation of responsive polymer microspheres
Sonochemical production and activation of responsive polymer microspheres Open
This paper reports work aimed at extending previous studies of the sonochemical method for forming microspheres. It shows that a previously reported method for encapsulating and delivering hydrophilic species using a 'double emulsion' meth…
View article: Comparison of the effects of gamma or sonochemical irradiation of carbon nanotubes and the influence on the mechanical and dielectric properties of chitosan nanocomposites
Comparison of the effects of gamma or sonochemical irradiation of carbon nanotubes and the influence on the mechanical and dielectric properties of chitosan nanocomposites Open
Chitosan-carbon nanotube (Chi-CNT) composite materials have been prepared with CNTs that were surface treated using either dilute acid combined with 20 kHz ultrasound or gamma-irradiation in air. The mechanical and dielectric properties ha…
View article: Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics
Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics Open
Molecular imaging has become a powerful technique in preclinical and clinical research aiming towards the diagnosis of many diseases. In this work, we address the synthetic challenges in achieving lab‐scale, batch‐to‐batch reproducible cop…
View article: Influence of Poly(styrene-<i>co</i>-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs
Influence of Poly(styrene-<i>co</i>-maleic acid) Copolymer Structure on the Properties and Self-Assembly of SMALP Nanodiscs Open
Polymer stabilized nanodiscs are self-assembled structures composed of a polymer belt that wraps around a segment of lipid bilayer, and as such are capable of encapsulating membrane proteins directly from the cell membrane. To date, most s…
View article: Sonochemical modification of carbon nanotubes for enhanced nanocomposite performance
Sonochemical modification of carbon nanotubes for enhanced nanocomposite performance Open
Multi-walled carbon nanotubes (CNTs) have been treated using 20kHz ultrasound in combination with dilute nitric and sulfuric acids at much lower concentrations than previously reported. The measurements revealed an optimum set of sonicatio…