Garrett McDaniel
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miR29a-Loaded Extracellular Vesicles Derived from Human Mesenchymal Stem Cells Inhibit Fibrotic and Inflammatory Signaling Open
Fibrotic processes involve aberrant deposition of extracellular matrix and contribute to ∼ 45% of all deaths in the developed world. Fibrotic remodeling results in stiffening of the local tissue environment, driving a self-amplifying feedb…
Actin Branching Regulates Cell Spreading and Force on Talin, but not Activation of YAP Open
Cells sense the mechanical properties of their environment through physical engagement and spreading, with high stiffness driving nuclear translocation of the mechanosensitive transcription factor YAP. Restriction of cell spread area or en…
View article: Viscoelasticity of Hyaluronic Acid Hydrogels Regulates Human Pluripotent Stem Cell‐derived Spinal Cord Organoid Patterning and Vascularization
Viscoelasticity of Hyaluronic Acid Hydrogels Regulates Human Pluripotent Stem Cell‐derived Spinal Cord Organoid Patterning and Vascularization Open
Recently, it has been recognized that natural extracellular matrix (ECM) and tissues are viscoelastic, while only elastic properties have been investigated in the past. How the viscoelastic matrix regulates stem cell patterning is critical…