Garry Cuneo
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View article: Detection and quantification of enzymatically active prostate-specific antigen<i>in vivo</i>
Detection and quantification of enzymatically active prostate-specific antigen<i>in vivo</i> Open
Assays for blood levels of prostate-specific antigen (PSA), performed in prostate cancer detection, measure mostly inactive/complexed PSA and do not provide information regarding enzymatically active PSA, which is biologically more relevan…
View article: In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia
In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia Open
Carbonic anhydrase IX (CA IX) is a transmembrane protein that has been shown to be greatly upregulated under conditions of hypoxia in many tumor cell lines. Tumor hypoxia is associated with impaired efficacy of cancer therapies making CA I…
View article: Noninvasive<i>In Vivo</i>Quantification of Neutrophil Elastase Activity in Acute Experimental Mouse Lung Injury
Noninvasive<i>In Vivo</i>Quantification of Neutrophil Elastase Activity in Acute Experimental Mouse Lung Injury Open
We developed a neutrophil elastase-specific near-infrared fluorescence imaging agent, which, combined with fluorescence molecular tomographic imaging, allowed us to detect and quantify neutrophil elastase activity in vivo , in real time, a…