Garry McDowell
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View article: Heart failure diagnosis: Impacts of atrial fibrillation on the diagnostic marker NT-proBNP
Heart failure diagnosis: Impacts of atrial fibrillation on the diagnostic marker NT-proBNP Open
A recent PLOS Medicine study shows that atrial fibrillation lowers the specificity of the biomarker NT-proBNP for heart failure. Adjusted thresholds and better echocardiography access are therefore required for NT-proBNP to remain as a hig…
View article: The Prognostic Value of High-Sensitivity CRP in the East Asian Population
The Prognostic Value of High-Sensitivity CRP in the East Asian Population Open
View article: Evaluating the Prognostic Significance of Circulating Biomarkers of End Organ Damage in Hypertension
Evaluating the Prognostic Significance of Circulating Biomarkers of End Organ Damage in Hypertension Open
Background: Most patients with hypertension exhibit elevated and detectable levels of natriuretic peptides, particularly BNP and NT-proBNP, as well as troponin concentrations. However, the prognostic relevance of this finding has not been …
View article: 5-021 Evaluating the prognostic significance of circulating biomarkers of end organ damage in hypertension: a systematic literature review
5-021 Evaluating the prognostic significance of circulating biomarkers of end organ damage in hypertension: a systematic literature review Open
View article: Associations of Sarcopenia and Its Components With Cardiovascular Risk: Five‐Year Longitudinal Evidence From China Health and Retirement Longitudinal Study
Associations of Sarcopenia and Its Components With Cardiovascular Risk: Five‐Year Longitudinal Evidence From China Health and Retirement Longitudinal Study Open
Background Sarcopenia, an age‐related condition, has an unclear association with cardiovascular disease (CVD) risk. We aimed to analyze whether sarcopenia and its individual components are associated with new‐onset CVD in middle‐aged and o…
View article: Cardiovascular risk in multiple sclerosis: exploring the role of vitamin D - insights from the Cardio-MS project
Cardiovascular risk in multiple sclerosis: exploring the role of vitamin D - insights from the Cardio-MS project Open
Background People with multiple sclerosis (pwMS) face elevated cardiovascular disease (CVD) risk. While traditional CVD risk factors are established, their impact on major adverse cardiovascular events (MACE) in pwMS is underexplored. Addi…
View article: Lipoprotein(a) and new-onset atrial fibrillation: where does the evidence lead us?
Lipoprotein(a) and new-onset atrial fibrillation: where does the evidence lead us? Open
View article: Role of oxidative balance score in staging and mortality risk of cardiovascular-kidney-metabolic syndrome: Insights from traditional and machine learning approaches
Role of oxidative balance score in staging and mortality risk of cardiovascular-kidney-metabolic syndrome: Insights from traditional and machine learning approaches Open
View article: Correction to “Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)” [The Lancet Regional Health – Europe 49 (2025) 101182]
Correction to “Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)” [The Lancet Regional Health – Europe 49 (2025) 101182] Open
[This corrects the article DOI: 10.1016/j.lanepe.2024.101182.].
View article: Cardiac Biomarkers Predict Major Adverse Cardiac Events (MACE) in Incident Haemodialysis Patients: Results from a Global Federated Database
Cardiac Biomarkers Predict Major Adverse Cardiac Events (MACE) in Incident Haemodialysis Patients: Results from a Global Federated Database Open
Background: Despite its many advantages, haemodialysis (HD) has been shown to be associated with significant cardiovascular events, especially in patients commencing HD. Currently, there is no specific method to risk-stratify incident HD p…
View article: Exploring the prognostic impact of triglyceride-glucose index in critically ill patients with first-ever stroke: insights from traditional methods and machine learning-based mortality prediction
Exploring the prognostic impact of triglyceride-glucose index in critically ill patients with first-ever stroke: insights from traditional methods and machine learning-based mortality prediction Open
View article: Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)
Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015) Open
Polish Lipid Association, College of Family Physician in Poland, Valeant in Poland.
View article: Prognostic value of glycaemic variability for mortality in critically ill atrial fibrillation patients and mortality prediction model using machine learning
Prognostic value of glycaemic variability for mortality in critically ill atrial fibrillation patients and mortality prediction model using machine learning Open
View article: A European network to develop virtual twin technology for personalized stroke management in atrial fibrillation: the TARGET consortium
A European network to develop virtual twin technology for personalized stroke management in atrial fibrillation: the TARGET consortium Open
Atrial fibrillation (AF) is a prevalent heart arrhythmia that increases stroke risk, leading to severe complications, high costs, and poor recovery outcomes. To address this, the European Union’s Horizon Europe research programme has funde…
View article: Phenotypes of South Asian patients with atrial fibrillation and holistic integrated care management: cluster analysis of data from KERALA-AF Registry
Phenotypes of South Asian patients with atrial fibrillation and holistic integrated care management: cluster analysis of data from KERALA-AF Registry Open
Kerala Chapter of Cardiological Society of India.
View article: Outcomes associated with Sodium-glucose cotransporter-2 inhibitors in kidney transplant recipients: A real-world analysis using a global federated database.
Outcomes associated with Sodium-glucose cotransporter-2 inhibitors in kidney transplant recipients: A real-world analysis using a global federated database. Open
Rationale & Objective: Several trials have shown the nephroprotective and cardiovascular benefits of sodium-glucose cotransporter-2 inhibitors (SGLT2i) among patients with native kidney disease. However, little is known about the safety an…
View article: Routine cardiac biomarkers for the prediction of incident major adverse cardiac events in patients with glomerulonephritis: a real-world analysis using a global federated database
Routine cardiac biomarkers for the prediction of incident major adverse cardiac events in patients with glomerulonephritis: a real-world analysis using a global federated database Open
Rationale & objective Glomerulonephritis (GN) is a leading cause of chronic kidney disease (CKD). Major adverse cardiovascular events (MACE) are prolific in CKD. The risk of MACE in GN cohorts is multifactorial. We investigated the prognos…
View article: 126 Identifying at-risk patients for atrial high-rate episodes by machine learning
126 Identifying at-risk patients for atrial high-rate episodes by machine learning Open
Background Current evidence suggests that atrial high rate episodes (AHRE)/subclinical atrial fibrillation are associated with increasing risk of clinical AF, and subsequently, ischaemic stroke and other adverse cardiovascular events. Purp…
View article: 163 Prediction of outcomes in patients with hypertension using clinical laboratory biomarkers - a real-world analysis using a global federated database
163 Prediction of outcomes in patients with hypertension using clinical laboratory biomarkers - a real-world analysis using a global federated database Open
Background Hypertension is a recognised risk factor for heart failure. The use of biomarkers in heart failure is long established, however little is known about the prognostic significance of these in hypertension when heart failure has be…
View article: 159 Diagnostic and prognostic significance of cancer antigen 125 in heart failure. A real-world analysis using a global federated database
159 Diagnostic and prognostic significance of cancer antigen 125 in heart failure. A real-world analysis using a global federated database Open
Background Cancer Antigen 125 (CA125) is a large transmembrane protein. Previous studies in heart failure have demonstrated that CA125 is associated with measures of vascular congestion, inflammation, and long-term outcome, especially rega…
View article: Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review
Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review Open
Hypertension (HT) is a disease that poses a serious threat to human health, mediating organ damage such as the cardiovascular (CV) system, kidneys, central nervous system (CNS), and retinae, ultimately increasing the risk of death due to d…
View article: The current use of proteomics and metabolomics in glomerulonephritis: a systematic literature review
The current use of proteomics and metabolomics in glomerulonephritis: a systematic literature review Open
View article: Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis
Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis Open
View article: Predicting stroke in Asian patients with atrial fibrillation using machine learning: A report from the KERALA-AF registry, with external validation in the APHRS-AF registry
Predicting stroke in Asian patients with atrial fibrillation using machine learning: A report from the KERALA-AF registry, with external validation in the APHRS-AF registry Open
View article: C-reactive protein in Stroke-Heart-Syndrome: a propensity-matched analysis of a global federated health network
C-reactive protein in Stroke-Heart-Syndrome: a propensity-matched analysis of a global federated health network Open
Introduction The role of inflammation in the Stroke-Heart-Syndrome is unclear. Purpose To assess the predictive role of C-Reactive Protein (CRP) for early cardiovascular complications in patients with stroke. Methods Electronic medical rec…
View article: #4779 CARDIAC BIOMARKERS FOR THE PREDICTION OF INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS
#4779 CARDIAC BIOMARKERS FOR THE PREDICTION OF INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS Open
Background and Aims Despite its advantages, haemodialysis (HD) is associated with increased cardiovascular mortality and morbidity, with some studies reporting 48% higher mortality within 2 years of starting HD. Currently, there are no est…
View article: 208 Prediction of incident major adverse cardiac events in patients starting haemodialysis for end stage kidney disease, using clinical laboratory cardiac biomarkers: a real world analysis
208 Prediction of incident major adverse cardiac events in patients starting haemodialysis for end stage kidney disease, using clinical laboratory cardiac biomarkers: a real world analysis Open
Background and Aims Despite its many advantages, haemodialysis (HD) is associated with increased cardiovascular mortality and morbidity, with some studies reporting 48% higher mortality within 2 years of starting HD. Cardiac biomarkers pro…
View article: #4787 VITAMIN D AND PARATHYROID HORMONE PREDICT INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS
#4787 VITAMIN D AND PARATHYROID HORMONE PREDICT INCIDENT MAJOR ADVERSE CARDIAC EVENTS IN PATIENTS STARTING HAEMODIALYSIS: A REAL-WORLD ANALYSIS Open
Background and Aims Despite its advantages, haemodialysis (HD) is associated with increased cardiovascular mortality and morbidity, with some studies reporting 48% higher mortality, within 2 years of starting treatment. HD patients are kno…
View article: 54 A mildly elevated troponin predicts 30-day outcome in patients presenting to the emergency department with chest pain where acute myocardial infarction is excluded. A real-world analysis
54 A mildly elevated troponin predicts 30-day outcome in patients presenting to the emergency department with chest pain where acute myocardial infarction is excluded. A real-world analysis Open
Background and Aims In patients presenting with chest pain, cardiac troponins are well recognised as a rule-out test for the diagnosis of myocardial infarction in the emergency department. The prognostic significance of mildly elevated tro…
View article: C-reactive protein levels are associated with early cardiac complications or death in patients with acute ischemic stroke: a propensity-matched analysis of a global federated health from the TriNetX network
C-reactive protein levels are associated with early cardiac complications or death in patients with acute ischemic stroke: a propensity-matched analysis of a global federated health from the TriNetX network Open
The role of inflammation in predicting early cardiac complications among stroke patients is unclear. Electronic medical records from TriNetX, a global federated health research network, were used for this retrospective analysis. Patients w…