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View article: Evaluation of <i>in vitro</i> toxicity of common phytochemicals included in weight loss supplements using <scp> <sup>1</sup> H NMR </scp> spectroscopy
Evaluation of <i>in vitro</i> toxicity of common phytochemicals included in weight loss supplements using <span> <sup>1</sup> H NMR </span> spectroscopy Open
Herbal and dietary supplements (HDS) are popular among consumers seeking a ‘natural’ approach for improving their health; however, at present, there is a lack of evidence to support the claims of efficacy and safety for most of these produ…
View article: Herbal Weight Loss Supplements Induce Metabolomic In Vitro Changes Indicative of Oxidative Stress
Herbal Weight Loss Supplements Induce Metabolomic In Vitro Changes Indicative of Oxidative Stress Open
Background/Objectives: The prevalence of obesity continues to rise globally, and with this an increase in the use of herbal weight loss supplements (WLS). At present, there is limited evidence to support the efficacy and safety of WLS, and…
View article: Integrative multi-omics data provide insights into the biosynthesis of furanocoumarins and mechanisms regulating their accumulation in Angelica dahurica
Integrative multi-omics data provide insights into the biosynthesis of furanocoumarins and mechanisms regulating their accumulation in Angelica dahurica Open
Furocoumarins (FCs), important natural compounds with biodefense roles and pharmacological activities, are notably abundant in medicinal plant Angelica dahurica . However, its accumulation patterns over development stages in FC-enriched ti…
View article: Advances and Current Status in the Use of Cuticular Hydrocarbons for Forensic Entomology Applications
Advances and Current Status in the Use of Cuticular Hydrocarbons for Forensic Entomology Applications Open
Cuticular hydrocarbons (CHCs) are long-chain lipids found on the exoskeletons of insects, serving primarily as a protective barrier against water loss and environmental factors. In the last few decades, the qualitative and quantitative ana…
View article: Clinical prediction of wound re-epithelisation outcomes in non-severe burn injury using the plasma lipidome
Clinical prediction of wound re-epithelisation outcomes in non-severe burn injury using the plasma lipidome Open
Whilst wound repair in severe burns has received substantial research attention, non-severe burns (0.7), whilst high-density lipoprotein subfractions, phosphatidylinositols, phosphatidylcholines, and phosphatidylserines were associated wit…
View article: Integrative multi-omics data elucidating the biosynthesis and regulatory mechanisms of furanocoumarins in<i>Angelica dahurica</i>
Integrative multi-omics data elucidating the biosynthesis and regulatory mechanisms of furanocoumarins in<i>Angelica dahurica</i> Open
Furocoumarins (FCs) are crucial natural products playing a dual role as plant defense molecules and pharmacologically active substances. Angelica dahurica is a renowned herb with diverse and abundant FCs. However, the accumulation pattern …
View article: 1H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studies
1H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studies Open
The immortalised human hepatocellular HepG2 cell line is commonly used for toxicology studies as an alternative to animal testing due to its characteristic liver-distinctive functions. However, little is known about the baseline metabolic …
View article: A controlled method for the identification of forensic traces from clandestine grave fill
A controlled method for the identification of forensic traces from clandestine grave fill Open
Deceased human remains are often buried as a forensic countermeasure or method of disposal by homicide perpetrators. Owing to this, the excavation of clandestine grave sites is a task that forensic crime scene teams may only encounter a fe…
View article: The rapid separation and characterization of sulfates of tyrosine and its metabolites in reaction mixtures and human urine using a cyclic ion mobility device and mass spectrometry
The rapid separation and characterization of sulfates of tyrosine and its metabolites in reaction mixtures and human urine using a cyclic ion mobility device and mass spectrometry Open
Ion mobility (IM) separations, especially when combined with mass spectrometry, offer the opportunity for the rapid analysis and characterization of mixtures. However, the limited resolution afforded by many IM systems means that in practi…
View article: Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury
Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury Open
Globally, burns are a significant cause of injury that can cause substantial acute trauma as well as lead to increased incidence of chronic comorbidity and disease. To date, research has primarily focused on the systemic response to severe…
View article: An Environmental DNA Approach to the Isolation of Human Intra- and Extra-Cellular DNA from Large Volumes of Water from Crime Scenes
An Environmental DNA Approach to the Isolation of Human Intra- and Extra-Cellular DNA from Large Volumes of Water from Crime Scenes Open
Forensic samples for DNA analysis are limited by physical size and volume as DNA extraction methods require small portions placed into 1.5 or 2.0 mL tubes for lysis. Apart from tape lifting techniques, this precludes large sample areas fro…
View article: Clinical prediction of wound re-epithelisation outcomes in non-severe burn injury using the plasma lipidome
Clinical prediction of wound re-epithelisation outcomes in non-severe burn injury using the plasma lipidome Open
Whilst wound repair in severe burns has received substantial research attention, non-severe burns (<20% total body surface area) remain relatively understudied, despite causing considerable physiological impact and constituting most of the…
View article: Non-severe burns induce a prolonged systemic metabolic phenotype indicative of a persistent inflammatory response post-injury
Non-severe burns induce a prolonged systemic metabolic phenotype indicative of a persistent inflammatory response post-injury Open
Globally, burns are a significant cause of injury that can cause substantial acute trauma as well as lead to increased incidence of chronic co-morbidity and disease. To date, research has primarily focused on the systemic response to sever…
View article: Comprehensive Lipidomic Workflow for Multicohort Population Phenotyping Using Stable Isotope Dilution Targeted Liquid Chromatography-Mass Spectrometry
Comprehensive Lipidomic Workflow for Multicohort Population Phenotyping Using Stable Isotope Dilution Targeted Liquid Chromatography-Mass Spectrometry Open
Dysregulated lipid metabolism underpins many chronic diseases including cardiometabolic diseases. Mass spectrometry-based lipidomics is an important tool for understanding mechanisms of lipid dysfunction and is widely applied in epidemiolo…
View article: Tea-Soybean Intercropping Improves Tea Quality and Nutrition Uptake by Inducing Changes of Rhizosphere Bacterial Communities
Tea-Soybean Intercropping Improves Tea Quality and Nutrition Uptake by Inducing Changes of Rhizosphere Bacterial Communities Open
The positive aspects of the tea plant/legume intercropping system draw attention to the Chinese tea industry for its benefit for soil fertility improvement with low fertilizer input. However, limited information exists as to the roles of i…
View article: The Effect of Ozone Treatment on Metabolite Profile of Germinating Barley
The Effect of Ozone Treatment on Metabolite Profile of Germinating Barley Open
Ozone is widely used to control pests in grain and impacts seed germination, a crucial stage in crop establishment which involves metabolic alterations. In this study, dormancy was overcome through after-ripening (AR) in dry barley seed st…
View article: Ozone Efficiency on Two Coleopteran Insect Pests and Its Effect on Quality and Germination of Barley
Ozone Efficiency on Two Coleopteran Insect Pests and Its Effect on Quality and Germination of Barley Open
Ozone (O3) is a potential fumigant to control pests in stored grain since it can safely and rapidly auto-decompose without leaving residues. In this study, the efficacy of O3 on all life stages of Rhyzopertha dominica (Fabricius) and Tribo…
View article: Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases
Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases Open
Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kid…
View article: Murder-suicide by Tanax® - Pathology, toxicology and veterinary analysis of a forensic case
Murder-suicide by Tanax® - Pathology, toxicology and veterinary analysis of a forensic case Open
Poisoning by Tanax® is uncommon as a suicide method, and it is even more unusual for murder-suicides. Tanax® is a veterinary drug used for euthanasia in animals and, as such, poisoning by Tanax® is almost completely limited to veterinary w…
View article: Characterizing the plasma metabolome during 14 days of live‐high, train‐low simulated altitude: A metabolomic approach
Characterizing the plasma metabolome during 14 days of live‐high, train‐low simulated altitude: A metabolomic approach Open
New Findings What is the central question of this study? Does 14 days of live‐high, train‐low simulated altitude alter an individual's metabolomic/metabolic profile? What is the main finding and its importance? This study demonstrated that…
View article: Untargeted Metabolomic Analysis of Rat Neuroblastoma Cells as a Model System to Study the Biochemical Effects of the Acute Administration of Methamphetamine
Untargeted Metabolomic Analysis of Rat Neuroblastoma Cells as a Model System to Study the Biochemical Effects of the Acute Administration of Methamphetamine Open
Methamphetamine is an illicit psychostimulant drug that is linked to a number of diseases of the nervous system. The downstream biochemical effects of its primary mechanisms are not well understood, and the objective of this study was to i…
View article: Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study
Repetitive low intensity magnetic field stimulation in a neuronal cell line: a metabolomics study Open
Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanism…
View article: Repetitive low intensity magnetic field stimulation in a neuronal cell line: A metabolomics study
Repetitive low intensity magnetic field stimulation in a neuronal cell line: A metabolomics study Open
Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanism…
View article: Repetitive low intensity magnetic field stimulation in a neuronal cell line: A metabolomics study
Repetitive low intensity magnetic field stimulation in a neuronal cell line: A metabolomics study Open
Low intensity repetitive magnetic stimulation of neural tissue modulates neuronal excitability and has promising therapeutic potential in the treatment of neurological disorders. However, the underpinning cellular and biochemical mechanism…
View article: What risks do herbal products pose to the Australian community?
What risks do herbal products pose to the Australian community? Open
Traditional herbal products are widely used in Australia to treat a broad range of conditions and diseases. It is popularly believed that these products are safer than prescribed drugs. While many may be safe, it is worrying that the speci…