Gary A. Jarvis
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View article: Cyclization increases bactericidal activity of arginine-rich cationic cell-penetrating peptide for <i>Neisseria gonorrhoeae</i>
Cyclization increases bactericidal activity of arginine-rich cationic cell-penetrating peptide for <i>Neisseria gonorrhoeae</i> Open
We previously reported that a linear cationic 12-amino acid cell-penetrating peptide (CPP) was bactericidal for Neisseria gonorrhoeae . In this study, our objectives were to determine the effect of cyclization of the linear CPP on its anti…
View article: <i>Neisseria gonorrhoeae</i> scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation
<i>Neisseria gonorrhoeae</i> scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation Open
Gonorrhea, caused by the bacterium Neisseria gonorrhoeae (Gc), is characterized by neutrophilic influx to infection sites. Gc has developed mechanisms to resist killing by neutrophils that include modifications to its surface lipooligosacc…
View article: <i>Neisseria gonorrhoeae</i>scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation
<i>Neisseria gonorrhoeae</i>scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation Open
Gonorrhea, caused by the bacterium Neisseria gonorrhoeae (Gc), is characterized by neutrophil influx to infection sites. Gc has developed mechanisms to resist killing by neutrophils that include modifications to its surface lipooligosaccha…
View article: Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae
Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae Open
The alarming rise of antibiotic resistance and the emergence of new vaccine technologies have increased the focus on vaccination to control gonorrhea. Neisseria gonorrhoeae strains FA1090 and MS11 have been used in challenge studies in hum…
View article: Novel small molecules that increase the susceptibility of <i>Neisseria gonorrhoeae</i> to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase
Novel small molecules that increase the susceptibility of <i>Neisseria gonorrhoeae</i> to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase Open
Objectives Neisseria gonorrhoeae is an exclusively human pathogen that commonly infects the urogenital tract resulting in gonorrhoea. Empirical treatment of gonorrhoea with antibiotics has led to multidrug resistance and the need for new t…
View article: Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome
Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome Open
Neisseria gonorrhoeae is a common sexually transmitted pathogen that significantly impacts female fertility, neonatal health, and transmission of HIV worldwide. N. gonorrhoeae usually causes localized inflammation of the urethra and cervix…
View article: Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS
Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS Open
Among the virulence factors in Neisseria infections, a major inducer of inflammatory cytokines is the lipooligosaccharide (LOS). The activation of NF-κB via extracellular binding of LOS or lipopolysaccharide (LPS) to the toll-like r…
View article: Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence
Novel Campylobacter concisus lipooligosaccharide is a determinant of inflammatory potential and virulence Open
The pathogenicity of Campylobacter concisus, increasingly found in the human gastrointestinal (GI) tract, is unclear. Some studies indicate that its role in GI conditions has been underestimated, whereas others suggest that the orga…
View article: Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors
Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors Open
Our in vitro results demonstrated promising efficacy of LpxC inhibition of N. gonorrhoeae that warrants further investigation particularly owing to the rise in MDR gonorrhoea.
View article: Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections
Innate immune response to lipooligosaccharide: pivotal regulator of the pathobiology of invasive Neisseria meningitidis infections Open
Infections due to Neisseria meningitidis afflict more than one million people worldwide annually and cause death or disability in many survivors. The clinical course of invasive infections has been well studied, but our understanding of th…
View article: Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding Open
Significance At this time, multidrug-resistant gram-negative bacteria are estimated to cause approximately 700,000 deaths per year globally, with a prediction that this figure could reach 10 million a year by 2050. Antivirulence therapy, i…
View article: Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae
Arginine- and Polyamine-Induced Lactic Acid Resistance in Neisseria gonorrhoeae Open
Microbe-derived lactic acid protects women from pathogens in their genital tract. The purpose of this study was to determine lactic acid susceptibility of Neisseria gonorrhoeae, and identify potential acid resistance mechanisms present in …
View article: Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage
Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage Open
The degree of phosphorylation and phosphoethanolaminylation of lipid A on neisserial lipooligosaccharide (LOS), a major cell-surface antigen, can be correlated with inflammatory potential and the ability to induce immune tolerance in vitro…