Gary Hannon
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A research toolbox for regional data collection to support the conservation of large batoids: A case study on the critically endangered flapper skate ( <i>Dipturus intermedius</i> ) Open
Elasmobranchs, specifically skate species (superorder Batoidea), are at risk of extinction, with over one‐third currently listed as Endangered, exacerbated due to their k‐selected life strategy. A regional conservation approach is required…
Blocking LIF and PD-L1 enhances the antitumor efficacy of SBRT in murine PDAC models Open
Background Recent preclinical and clinical data suggest that leukemia inhibitory factor (LIF) is a potential target for various tumor types including pancreatic ductal adenocarcinoma as LIF is involved in multiple protumor processes includ…
Blockade of LIF and PD-L1 Enhances Chemotherapy in Preclinical PDAC Models Open
Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC), expecting to be the second leading cause of cancer deaths by 2030, resists immune checkpoint therapies due to its immunosuppressive tumor microenvironment (TME). Leukemia inhi…
Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer Open
Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this suppression. Traditional immunotherapies, such as immune checkpoint blockade, often fai…
Inflammation related to inhalation of nano and micron sized iron oxides: a systematic review Open
Inhalation exposure to iron oxide occurs in many workplaces and respirable aerosols occur during thermal processes (e.g. welding, casting) or during abrasion of iron and steel products (e.g. cutting, grinding, machining, polishing, sanding…
Interlaboratory comparison of endotoxin contamination assessment of nanomaterials Open
Endotoxin contamination is a significant hurdle to the translation of nanomaterials for biomedical applications.
Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer Open
The immunosuppressive milieu in pancreatic cancer (PC) is a significant hurdle to treatments, resulting in survival statistics that have barely changed in 5 decades. Here we present a combination treatment consisting of stereotactic body r…
View article: A holistic and comprehensive data approach validates the distribution of the critically endangered flapper skate (<i>Dipturus intermedius</i>)
A holistic and comprehensive data approach validates the distribution of the critically endangered flapper skate (<i>Dipturus intermedius</i>) Open
Morphological similarities between skates of the genus Dipturus in the north‐eastern Atlantic and Mediterranean have resulted in longstanding confusion, misidentification and misreporting. Current evidence indicates that the common skate i…
CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models Open
Background Stereotactic body radiotherapy (SBRT) induces immunogenic cell death, leading to subsequent antitumor immune response that is in part counterbalanced by activation of immune evasive processes, for example, upregulation of progra…
Harnessing the Immunological Effects of Radiation to Improve Immunotherapies in Cancer Open
Ionizing radiation (IR) is used to treat 50% of cancers. While the cytotoxic effects related to DNA damage with IR have been known since the early 20th century, the role of the immune system in the treatment response is still yet to be ful…
Thermal ablation in pancreatic cancer: A scoping review of clinical studies Open
Background Pancreatic cancer is a deadly cancer with a 5-year survival rate less than 10%. Only 20% of patients are eligible to receive surgery at diagnosis. Hence, new therapies are needed to improve outcomes for non-surgical candidates. …
Endotoxin contamination of engineered nanomaterials: Overcoming the hurdles associated with endotoxin testing Open
Nanomaterials are highly susceptible to endotoxin contamination due their large surface‐to‐volume ratios and endotoxins propensity to associate readily to hydrophobic and cationic surfaces. Additionally, the stability of endotoxin ensures …
View article: Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range
Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range Open
Light scattering-based measurements do not have the resolution to distinguish multiple populations in polydisperse samples. Nanoparticle tracking analysis (NTA), nano-flowcytometry (nFCM) and asymmetric flow field flow fractionation hyphen…
Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells Open
Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials in various solid …
Immunotoxicity Considerations for Next Generation Cancer Nanomedicines Open
Although interest and funding in nanotechnology for oncological applications is thriving, translating these novel therapeutics through the earliest stages of preclinical assessment remains challenging. Upon intravenous administration, nano…