Gary Hoffmann
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View article: Deciphering the mechanism of protein aggregation and effects of inhibitors using single-molecule mass photometry
Deciphering the mechanism of protein aggregation and effects of inhibitors using single-molecule mass photometry Open
Aggregation of misfolded proteins is a prominent feature of many diseases and hence an attractive drug target. However, the small oligomers that are critical early species in the aggregation cascade are difficult to monitor directly owing …
View article: Timing the Escape of a Caged Electron
Timing the Escape of a Caged Electron Open
Charge transfer is fundamentally dependent on the overlap of the orbitals comprising the transport pathway. This has key implications for molecular, nanoscale, and quantum technologies, for which delocalization (and decoherence) rates are …
View article: Anchor-Enhanced Bead Design for Reduced Oligonucleotide Synthesis Errors in Single-cell sequencing
Anchor-Enhanced Bead Design for Reduced Oligonucleotide Synthesis Errors in Single-cell sequencing Open
Single-cell transcriptomics, reliant on the incorporation of barcodes and unique molecular identifiers (UMIs) into captured polyA+ mRNA, faces a significant challenge due to synthesis errors in oligonucleotide capture sequences. These inac…
View article: Solid-state $^3\mathrm{He}$ NMR of the superconducting rubidium endofulleride $\mathrm{Rb_3(^3He@C_{60})}$
Solid-state $^3\mathrm{He}$ NMR of the superconducting rubidium endofulleride $\mathrm{Rb_3(^3He@C_{60})}$ Open
A new variant of the superconducting fulleride $\mathrm{Rb_{3}C_{60}}$ is presented, with $\mathrm{^{3}He}$ atoms encapsulated in the $\mathrm{C_{60}}$ cages. The $\mathrm{^{3}He}$ nuclei act as sensitive NMR probes embedded in the materia…
View article: Ne, Ar, and Kr oscillators in the molecular cavity of fullerene C60
Ne, Ar, and Kr oscillators in the molecular cavity of fullerene C60 Open
We used THz (terahertz) and INS (inelastic neutron scattering) spectroscopies to study the interaction between an endohedral noble gas atom and the C60 molecular cage. The THz absorption spectra of powdered A@C60 samples (A = Ar, Ne, Kr) w…
View article: Correcting PCR amplification errors in unique molecular identifiers to generate absolute numbers of sequencing molecules
Correcting PCR amplification errors in unique molecular identifiers to generate absolute numbers of sequencing molecules Open
Unique Molecular Identifiers (UMIs) are random oligonucleotide sequences that remove PCR amplification biases. However, the impact that PCR associated sequencing errors have on the accuracy of generating absolute counts of RNA molecules is…
View article: A combined inelastic neutron scattering and simulation study of the <sup>3</sup>He@C<sub>60</sub> endofullerene
A combined inelastic neutron scattering and simulation study of the <sup>3</sup>He@C<sub>60</sub> endofullerene Open
Uniting inelastic neutron scattering and numerical simulations to fully understand the dynamics of 3 He atoms confined within C 60 cages.
View article: Correction: Terahertz spectroscopy of the helium endofullerene He@C<sub>60</sub>
Correction: Terahertz spectroscopy of the helium endofullerene He@C<sub>60</sub> Open
Correction for ‘Terahertz spectroscopy of the helium endofullerene He@C 60 ’ by Tanzeeha Jafari et al. , Phys. Chem. Chem. Phys. , 2022, 24 , 9943–9952, https://doi.org/10.1039/D2CP00515H.
View article: CCDC 2141931: Experimental Crystal Structure Determination
CCDC 2141931: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and <sup>83</sup>Kr NMR spectroscopy of Kr@C<sub>60</sub>
Synthesis and <sup>83</sup>Kr NMR spectroscopy of Kr@C<sub>60</sub> Open
Synthesis of Kr@C 60 is achieved by a synthetic route that involves quantitative encapsulation of krypton by an open-cage derivative of C 60 . Fine structure is observed in the 13 C NMR spectrum, and 83 Kr NMR characterisation is carried o…
View article: Terahertz spectroscopy of the helium endofullerene He@C<sub>60</sub>
Terahertz spectroscopy of the helium endofullerene He@C<sub>60</sub> Open
The confinement potential of the He atom encapsulated by the C 60 molecular cage is obtained from the terahertz spectra.
View article: Experimental determination of the interaction potential between a helium atom and the interior surface of a C<sub>60</sub> fullerene molecule.
Experimental determination of the interaction potential between a helium atom and the interior surface of a C<sub>60</sub> fullerene molecule. Open
The interactions between atoms and molecules may be described by a potential energy function of the nuclear coordinates. Nonbonded interactions between neutral atoms or molecules are dominated by repulsive forces at a short range and attra…
View article: Experimental determination of the interaction potential between a helium atom and the interior surface of a C60 fullerene molecule
Experimental determination of the interaction potential between a helium atom and the interior surface of a C60 fullerene molecule Open
The interactions between atoms and molecules may be described by a potential energy function of the nuclear coordinates. Nonbonded interactions between neutral atoms or molecules are dominated by repulsive forces at a short range and attra…
View article: THz and IR spectroscopy of endofullerene H2O@C60
THz and IR spectroscopy of endofullerene H2O@C60 Open
Terahertz time-domain and infrared Fourier-transform spectroscopy techniques are used to investigate the properties of H 2 O@C 60 endofullerene in 6 K – 300 K temperature interval. A number of absorption lines associated with rotational tr…
View article: A Solid‐State Intramolecular Wittig Reaction Enables Efficient Synthesis of Endofullerenes Including Ne@C<sub>60</sub>, <sup>3</sup>He@C<sub>60</sub>, and HD@C<sub>60</sub>
A Solid‐State Intramolecular Wittig Reaction Enables Efficient Synthesis of Endofullerenes Including Ne@C<sub>60</sub>, <sup>3</sup>He@C<sub>60</sub>, and HD@C<sub>60</sub> Open
An open‐cage fullerene incorporating phosphorous ylid and carbonyl group moieties on the rim of the orifice can be filled with gases (H 2 , He, Ne) in the solid state, and the cage opening then contracted in situ by raising the temperature…
View article: A Solid‐State Intramolecular Wittig Reaction Enables Efficient Synthesis of Endofullerenes Including Ne@C<sub>60</sub>, <sup>3</sup>He@C<sub>60</sub>, and HD@C<sub>60</sub>
A Solid‐State Intramolecular Wittig Reaction Enables Efficient Synthesis of Endofullerenes Including Ne@C<sub>60</sub>, <sup>3</sup>He@C<sub>60</sub>, and HD@C<sub>60</sub> Open
An open‐cage fullerene incorporating phosphorous ylid and carbonyl group moieties on the rim of the orifice can be filled with gases (H 2 , He, Ne) in the solid state, and the cage opening then contracted in situ by raising the temperature…
View article: Electronic Spectroscopy of for Astrochemical Consideration
Electronic Spectroscopy of for Astrochemical Consideration Open
The electronic spectrum of the endohedral fullerene observed by messenger spectroscopy in a cryogenic ion trap is presented. The role played by the messenger tag in the adopted experimental method is evaluated by recording spectra of with …
View article: Fine structure in the solution state <sup>13</sup>C-NMR spectrum of C<sub>60</sub> and its endofullerene derivatives
Fine structure in the solution state <sup>13</sup>C-NMR spectrum of C<sub>60</sub> and its endofullerene derivatives Open
The 13C NMR spectrum of C60 in solution showing the additional side peaks from double-13C isotopomers.
View article: Synthesis of Ar@C<sub>60</sub> using molecular surgery
Synthesis of Ar@C<sub>60</sub> using molecular surgery Open
Synthesis of Ar@C60 is described, using a route in which high-pressure argon filling of an open-fullerene and photochemical desulfinylation are the key steps for >95% encapsulation of the noble gas.