Gary Royle
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View article: AI-powered immune profiling from histopathology slides for chemo-radiotherapy outcome prediction in rectal cancer: a study using clinical trial and real-world cohorts
AI-powered immune profiling from histopathology slides for chemo-radiotherapy outcome prediction in rectal cancer: a study using clinical trial and real-world cohorts Open
Cancer Research UK (RRNPSF-Jan21/100001, A18745, C7893/A2899), UK Research and Innovation (MR/T040785/1).
View article: A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides
A deep learning framework deploying segment anything to detect pan-cancer mitotic figures from haematoxylin and eosin-stained slides Open
Mitotic activity is an important feature for grading several cancer types. However, counting mitotic figures (cells in division) is a time-consuming and laborious task prone to inter-observer variation. Inaccurate recognition of MFs can le…
View article: Imaging lung tumor motion using integrated‐mode proton radiography—A phantom study towards tumor tracking in proton radiotherapy
Imaging lung tumor motion using integrated‐mode proton radiography—A phantom study towards tumor tracking in proton radiotherapy Open
Background Motion of lung tumors during radiotherapy leads to decreased accuracy of the delivered dose distribution. This is especially true for proton radiotherapy due to the finite range of the proton beam. Methods for mitigating motion …
View article: OMG-Net: A Deep Learning Framework Deploying Segment Anything to Detect Pan-Cancer Mitotic Figures from Haematoxylin and Eosin-Stained Slides
OMG-Net: A Deep Learning Framework Deploying Segment Anything to Detect Pan-Cancer Mitotic Figures from Haematoxylin and Eosin-Stained Slides Open
Mitotic activity is an important feature for grading several cancer types. Counting mitotic figures (MFs) is a time-consuming, laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incorrect grading an…
View article: OMG-Net: A Deep Learning Framework Deploying Segment Anything to Detect Pan-Cancer Mitotic Figures from Haematoxylin and Eosin-Stained Slides
OMG-Net: A Deep Learning Framework Deploying Segment Anything to Detect Pan-Cancer Mitotic Figures from Haematoxylin and Eosin-Stained Slides Open
Mitotic activity is an important feature for grading several cancer types. Counting mitotic figures (MFs) is a time-consuming, laborious task prone to inter-observer variation. Inaccurate recognition of MFs can lead to incorrect grading an…
View article: Integrated-mode proton radiography with 2D lateral projections
Integrated-mode proton radiography with 2D lateral projections Open
Integrated-mode proton radiography leading to water equivalent thickness (WET) maps is an avenue of interest for motion management, patient positioning, and in vivo range verification. Radiographs can be obtained using a pencil beam scanni…
View article: Evaluation of monte carlo to support commissioning of the treatment planning system of new pencil beam scanning proton therapy facilities
Evaluation of monte carlo to support commissioning of the treatment planning system of new pencil beam scanning proton therapy facilities Open
Objective . To demonstrate the potential of Monte Carlo (MC) to support the resource-intensive measurements that comprise the commissioning of the treatment planning system (TPS) of new proton therapy facilities. Approach . Beam models of …
View article: 6O Insights into tumour dissemination and progression using longitudinal imaging and ctDNA in the TRACERx lung cancer study
6O Insights into tumour dissemination and progression using longitudinal imaging and ctDNA in the TRACERx lung cancer study Open
Longitudinal imaging and circulating tumour DNA (ctDNA) can map tumour growth on a lesion level. We investigated the role of ctDNA as a biomarker in monitoring tumour growth in 103 patients with metastatic lung cancer enrolled in the TRACE…
View article: Isotoxic dose escalated radiotherapy for glioblastoma based on diffusion-weighted MRI and tumor control probability—an in-silico study
Isotoxic dose escalated radiotherapy for glioblastoma based on diffusion-weighted MRI and tumor control probability—an in-silico study Open
Objectives: Glioblastoma (GBM) is the most common malignant primary brain tumor with local recurrence after radiotherapy (RT), the most common mode of failure. Standard RT practice applies the prescription dose uniformly across tumor volum…
View article: A likelihood‐based particle imaging filter using prior information
A likelihood‐based particle imaging filter using prior information Open
Background Particle imaging can increase precision in proton and ion therapy. Interactions with nuclei in the imaged object increase image noise and reduce image quality, especially for multinucleon ions that can fragment, such as helium. …
View article: Development of optimised tissue-equivalent materials for proton therapy
Development of optimised tissue-equivalent materials for proton therapy Open
Objective . In proton therapy there is a need for proton optimised tissue-equivalent materials as existing phantom materials can produce large uncertainties in the determination of absorbed dose and range measurements. The aim of this work…
View article: A probability model for anatomical robust optimisation in head and neck cancer proton therapy
A probability model for anatomical robust optimisation in head and neck cancer proton therapy Open
Objective. Develop an anatomical model based on the statistics of the population data and evaluate the model for anatomical robust optimisation in head and neck cancer proton therapy. Approach. Deformable image registration was used to bui…
View article: Pre‐treatment analysis of non‐rigid variations can assist robust intensity‐modulated proton therapy plan selection for head and neck patients
Pre‐treatment analysis of non‐rigid variations can assist robust intensity‐modulated proton therapy plan selection for head and neck patients Open
Purpose To incorporate small non‐rigid variations of head and neck patients into the robust evaluation of intensity‐modulated proton therapy (IMPT) for the selection of robust treatment plans. Methods A cohort of 20 nasopharynx cancer pati…
View article: International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System
International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System Open
Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucia…
View article: Improving workflow for adaptive proton therapy with predictive anatomical modelling: A proof of concept
Improving workflow for adaptive proton therapy with predictive anatomical modelling: A proof of concept Open
Prediction-based replanning could potentially enable adaptive therapy to be delivered without treatment gaps or sub-optimal fractions, as can occur during a standard replanning strategy, though the benefit of using predicted plan adaption …
View article: DIR-based models to predict weekly anatomical changes in head and neck cancer proton therapy
DIR-based models to predict weekly anatomical changes in head and neck cancer proton therapy Open
Objective . We proposed two anatomical models for head and neck patients to predict anatomical changes during the course of radiotherapy. Approach . Deformable image registration was used to build two anatomical models: (1) the average mod…
View article: Determination of beam quality correction factors for the Roos plane-parallel ionisation chamber exposed to very high energy electron (VHEE) beams using Geant4
Determination of beam quality correction factors for the Roos plane-parallel ionisation chamber exposed to very high energy electron (VHEE) beams using Geant4 Open
Detailed characterisation of the Roos secondary standard plane-parallel ionisation chamber has been conducted in a novel 200 MeV Very High Energy Electron (VHEE) beam with reference to the standard 12 MeV electron calibration beam used in …
View article: A Geant4 Fano test for novel very high energy electron beams
A Geant4 Fano test for novel very high energy electron beams Open
Objective. The boundary crossing algorithm available in Geant4 10.07-p01 general purpose Monte Carlo code has been investigated for a 12 and 200 MeV electron source by the application of a Fano cavity test. Approach. Fano conditions were e…
View article: SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target
SSTR2 in Nasopharyngeal Carcinoma: Relationship with Latent EBV Infection and Potential as a Therapeutic Target Open
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor, most commonly located in the pharyngeal recess and endemic to parts of Asia. It is often detected at a late stage which is associated with poor prognosis (5-year survival rate…
View article: Assessment of the impact of CT calibration procedures for proton therapy planning on pediatric treatments
Assessment of the impact of CT calibration procedures for proton therapy planning on pediatric treatments Open
Purpose Relative stopping powers (RSPs) for proton therapy are estimated using single‐energy computed tomography (SECT), calibrated with standardized tissues of the adult male. It is assumed that those tissues are representative of tissues…
View article: Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy Open
Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin recep…
View article: Functional Imaging for Dose Painting in Radiotherapy
Functional Imaging for Dose Painting in Radiotherapy Open
Dose painting has been developed to modulate the required dose in the target area without increasing the toxicity in healthy areas. Apart from determining the accurate location and size of tumors, quantitative functional imaging can be use…