Gary Struhl
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Notch: A Signaling Protein That Helps Cells Make Big Decisions Open
As an organism develops from a single fertilized egg cell, how do all the different organs and tissues of its body come to be? How do some cells know to become nerves, others skin, and others bone or blood? We have spent decades studying a…
An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation Open
Notch proteins are single-pass transmembrane receptors activated by sequential extracellular and intramembrane cleavages to release the cytosolic domains that function as transcription factors. Transmembrane ligands of the Delta/Serrate/LA…
An in vivo screen for proteolytic switch domains that can mediate Notch activation by force Open
Notch proteins are single pass transmembrane receptors activated by sequential extracellular and intramembrane cleavages that release their cytosolic domains to function as transcription factors in the nucleus. Upon binding, Delta/Serrate/…
A unified mechanism for the control of Drosophila wing growth by the morphogens Decapentaplegic and Wingless Open
Development of the Drosophila wing—a paradigm of organ development—is governed by 2 morphogens, Decapentaplegic (Dpp, a BMP) and Wingless (Wg, a Wnt). Both proteins are produced by defined subpopulations of cells and spread outwards, formi…
The C. elegans Notch proteins LIN-12 and GLP-1 are tuned to lower force thresholds for activation than Drosophila Notch Open
The conserved transmembrane receptor Notch mediates cell fate decisions in all animals. In the absence of ligand, a Negative Regulatory Region (NRR) in the Notch ectodomain adopts an autoinhibited confirmation, masking an ADAM protease cle…
Control of <i>Drosophila</i> wing size by morphogen range and hormonal gating Open
Significance During normal development, animals and their constituent body parts stop growing when they reach the right size. However, the mechanisms that limit growth as a function of size are largely unknown. Growth of the Drosophila win…
Causal role for inheritance of H3K27me3 in maintaining the OFF state of a <i>Drosophila</i> HOX gene Open
DNA sequence and inherited gene silencing Cell fate decisions require a gene's transcriptional status, whether on or off, to be stably and heritably maintained over multiple cell generations. For silenced genes, heterochromatin domains are…