Gary W. Liu
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View article: Identification and Validation of Cyclic Peptides with Mucin-Selective, Location-Specific Binding in the Gastrointestinal Tract
Identification and Validation of Cyclic Peptides with Mucin-Selective, Location-Specific Binding in the Gastrointestinal Tract Open
Oral drug delivery is a widely preferred method of drug administration due to its ease of use and convenience for patients. Localization of drug release in the gastrointestinal (GI) tract is important to treat localized diseases and maximi…
View article: Self-aggregating long-acting injectable microcrystals
Self-aggregating long-acting injectable microcrystals Open
Injectable drug depots have transformed our capacity to enhance medication adherence through dose simplification. Central to patient adoption of injectables is the acceptability of needle injections, with needle gauge as a key factor infor…
View article: Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics
Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics Open
Pills are a cornerstone of medicine but can be challenging to swallow. While liquid formulations are easier to ingest, they lack the capacity to localize therapeutics with excipients nor act as controlled release devices. Here we describe …
View article: Drinkable, liquid<i>in situ</i>-forming and tough hydrogels for gastrointestinal therapeutics
Drinkable, liquid<i>in situ</i>-forming and tough hydrogels for gastrointestinal therapeutics Open
Tablets and capsules are a cornerstone of medicine, but these solid dosage forms can be challenging to swallow for geriatric and pediatric patients. While liquid formulations are easier to ingest, these formulations lack the capacity to lo…
View article: Nanoparticles exhibit greater accumulation in kidney glomeruli during experimental glomerular kidney disease
Nanoparticles exhibit greater accumulation in kidney glomeruli during experimental glomerular kidney disease Open
Loss and dysfunction of glomerular podocytes result in increased macromolecule permeability through the glomerular filtration barrier and nephrotic syndrome. Current therapies can induce and maintain disease remission, but cause serious an…
View article: Boronic Acid Copolymers for Direct Loading and Acid-Triggered Release of Bis-T-23 in Cultured Podocytes
Boronic Acid Copolymers for Direct Loading and Acid-Triggered Release of Bis-T-23 in Cultured Podocytes Open
We report an acid-reversible linker for triggered release of Bis-T-23, an experimental small molecule drug for kidney disease treatment that restores podocyte morphology during disease. Bis-T-23 contains catechols, which form an acid-rever…
View article: Photonic Crystal Optical Tweezers with High Efficiency for Live Biological Samples and Viability Characterization
Photonic Crystal Optical Tweezers with High Efficiency for Live Biological Samples and Viability Characterization Open
We propose and demonstrate a new optical trapping method for single cells that utilizes modulated light fields to trap a wide array of cell types, including mammalian, yeast and Escherichia coli cells, on the surface of a two-dimensional p…