Gastón Bergero
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View article: A novel mouse model for studying complications related to type 2 diabetes using a medium-fat diet, fructose, and streptozotocin
A novel mouse model for studying complications related to type 2 diabetes using a medium-fat diet, fructose, and streptozotocin Open
The study of type 2 diabetes mellitus (T2DM) pathophysiology relies mainly on the use of animal models, the most common of which involves the consumption of high-fat diets comprising 60% calories from fat. Although these models reproduce t…
View article: Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection
Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection Open
Chagas disease, caused by Trypanosoma cruzi, is endemic to Latin America and is characterized by chronic inflammation of cardiac tissues due to parasite persistence. Hypoxia within infected tissues may trigger the stabilization of HIF-1 an…
View article: A Novel Mouse Model of Type 2 Diabetes Using a Medium‒Fat Diet, Fructose, and Streptozotocin to Study the Complications of Human Disease
A Novel Mouse Model of Type 2 Diabetes Using a Medium‒Fat Diet, Fructose, and Streptozotocin to Study the Complications of Human Disease Open
The study of type 2 diabetes mellitus (T2DM) pathophysiology relies mainly on the use of animal models, the most common of which involves the consumption of high-fat diets comprising 60% calories from fat. Although these models reproduce t…
View article: Gut microbiota and immunometabolic response to Choline and Betaine supplementation in a Mouse Model of Diet-Induced Obesity
Gut microbiota and immunometabolic response to Choline and Betaine supplementation in a Mouse Model of Diet-Induced Obesity Open
Obesity is a chronic, recurring and multifactorial disease characterized by systemic inflammation, visceral adipose tissue dysfunction and gut microbiota dysbiosis. While Omega-3 fatty acids have shown beneficial effects in this context, t…
View article: Dietary Omega-3 Supplementation Shapes Gut Microbiota and Regulates Immunometabolism in a Mouse Model of Obesity
Dietary Omega-3 Supplementation Shapes Gut Microbiota and Regulates Immunometabolism in a Mouse Model of Obesity Open
Host-gut microbiota interactions play a pivotal role in shaping the delicate balance between health and disease within the human body. The impact of dietary factors, specifically high fat content diets on gut microbiota composition has bee…
View article: MICROBIOTA AT THE CROSS ROAD OF DIET AND HEALTH: HOW DIETARY FATS SHAPE BACTERIAL LAND-SCAPE AND INFLUENCE GLOBAL HEALTH
MICROBIOTA AT THE CROSS ROAD OF DIET AND HEALTH: HOW DIETARY FATS SHAPE BACTERIAL LAND-SCAPE AND INFLUENCE GLOBAL HEALTH Open
Host-gut microbiota (GM) interactions play a pivotal role in shaping the delicate balance between health and disease within the human body. The impact of dietary factors, specifically high fat content diets on GM composition has been widel…
View article: Differential expression patterns of purinergic ectoenzymes and the antioxidative role of IL-6 in hospitalized COVID-19 patient recovery
Differential expression patterns of purinergic ectoenzymes and the antioxidative role of IL-6 in hospitalized COVID-19 patient recovery Open
Introduction We have acquired significant knowledge regarding the pathogenesis of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2). However, the underlying mechanisms responsible for disease recovery still need to be …
View article: Omega-3-Supplemented Fat Diet Drives Immune Metabolic Response in Visceral Adipose Tissue by Modulating Gut Microbiota in a Mouse Model of Obesity
Omega-3-Supplemented Fat Diet Drives Immune Metabolic Response in Visceral Adipose Tissue by Modulating Gut Microbiota in a Mouse Model of Obesity Open
Obesity is a chronic, relapsing, and multifactorial disease characterized by excessive accumulation of adipose tissue (AT), and is associated with inflammation mainly in white adipose tissue (WAT) and an increase in pro-inflammatory M1 mac…
View article: Associations between objectively measured physical activity, sedentary time, and cardiorespiratory fitness with inflammatory and oxidative stress markers and heart rate variability
Associations between objectively measured physical activity, sedentary time, and cardiorespiratory fitness with inflammatory and oxidative stress markers and heart rate variability Open
Background: To assess the associations between physical activity (PA) and sedentary time (SEDT) with inflammatory and oxidative stress markers, heart rate variability (HRV) and post-exercise recovery (HRR) controlling for cardiorespiratory…
View article: Monocyte glycolysis determines CD8+ T cell functionality in human Chagas disease
Monocyte glycolysis determines CD8+ T cell functionality in human Chagas disease Open
Chagas disease is a lifelong pathology resulting from Trypanosoma cruzi infection. It represents one of the most frequent causes of heart failure and sudden death in Latin America. Herein, we provide evidence that aerobic glycolytic pathwa…