Gatphan Atassi
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View article: Molecular glue degrader function of SPOP enhances STING-dependent immunotherapy efficacy in melanoma models
Molecular glue degrader function of SPOP enhances STING-dependent immunotherapy efficacy in melanoma models Open
The E3 ligase SPOP plays a context-dependent role in cancer by targeting specific cellular proteins for degradation, thereby influencing cell behavior. However, its role in tumor immunity remains largely unexplored. In this study, we revea…
View article: Molecular glue degrader function of SPOP enhances STING-dependent immunotherapy efficacy in melanoma models
Molecular glue degrader function of SPOP enhances STING-dependent immunotherapy efficacy in melanoma models Open
The E3 ligase SPOP plays a context-dependent role in cancer by targeting specific cellular proteins for degradation, thereby influencing cell behavior. However, its role in tumor immunity remains largely unexplored. In this study, we revea…
View article: Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV
Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV Open
View article: CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms
CAR-redirected natural killer T cells demonstrate superior antitumor activity to CAR-T cells through multimodal CD1d-dependent mechanisms Open
View article: Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer
Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer Open
View article: Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV
Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV Open
In people with HIV (PWH), the post-antiretroviral therapy (ART) window is critical for immune restoration and HIV reservoir stabilization. We employ deep immune profiling and T cell receptor (TCR) sequencing and examine proliferation to as…
View article: CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis
CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis Open
LT-ART and A5248 folders contain preprocessed CyTOF files (FCS format) from a 31-marker mass cytometry panel to examine all major PBMC lineages and specifically CD4 and CD8 T cell memory dynamics in people with HIV (PWH) who are durably AR…
View article: CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis
CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis Open
LT-ART and A5248 folders contain preprocessed CyTOF files (FCS format) from a 31-marker mass cytometry panel to examine all major PBMC lineages and specifically CD4 and CD8 T cell memory dynamics in people with HIV (PWH) who are durably AR…
View article: CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis
CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis Open
Data folder contains preprocessed CyTOF files (FCS format) from a 31-marker mass cytometry panel to examine all major PBMC lineages and specifically CD4 and CD8 T cell memory dynamics in people with HIV (PWH) who are durably ART suppressed…