Gaurav Ghag
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View article: Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions
Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions Open
Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well unders…
View article: Skybell: A Doorbell Notification System
Skybell: A Doorbell Notification System Open
The use of the smartphone has increased steadily over the past years as large number of people are gaining access to smart phones.The aim of the paper is to integrate the functions of the smartphone and home security system and develop a s…
View article: Cysteine-rich granulin-3 rapidly promotes amyloid-β fibrils in both redox states
Cysteine-rich granulin-3 rapidly promotes amyloid-β fibrils in both redox states Open
Granulins (GRNs 1–7) are cysteine-rich proteolytic products of progranulin (PGRN) that have recently been implicated in neurodegenerative diseases including frontotemporal dementia (FTD) and Alzheimer's disease (AD). Their precise mechanis…
View article: Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross‐seeding behavior
Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross‐seeding behavior Open
Several studies have proposed that fibrillary aggregates of tau and other amyloidogenic proteins are neurotoxic and result in numerous neurodegenerative diseases. However, these studies usually involve sonication or extrusion through needl…
View article: Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity
Disulfide bonds and disorder in granulin‐3: An unusual handshake between structural stability and plasticity Open
Granulins (GRNs) are a family of small (∼6 kDa) proteins generated by the proteolytic processing of their precursor, progranulin (PGRN), in many cell types. Both PGRN and GRNs are implicated in a plethora of biological functions, often in …
View article: Disorder in Cysteine-Rich Granulin-3 and Its Implication in Alzheimer Disease
Disorder in Cysteine-Rich Granulin-3 and Its Implication in Alzheimer Disease Open
Granulins (GRNs) are a family of small, cysteine-rich proteins that are generated upon proteolytic cleavage of their precursor, progranulin (PGRN) during inflammation. All seven GRNs (1 – 7 or A – G) contain twelve conserved cysteines that…
View article: Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamics
Fully reduced granulin-B is intrinsically disordered and displays concentration-dependent dynamics Open
Granulins (Grns) are a family of small, cysteine-rich proteins that are generated upon proteolytic cleavage of their precursor, progranulin (Pgrn). All seven Grns (A-G) contain 12 conserved cysteines that form 6 intramolecular disulfide bo…