Gaurav Kharya
YOU?
Author Swipe
View article: AI-Guided CAR Designs and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen Escape
AI-Guided CAR Designs and AKT3 Degradation Synergize to Enhance Bispecific and Trispecific CAR-T Cell Persistence and Overcome Antigen Escape Open
The structural design of chimeric antigen receptors (CARs) is critical for achieving robust and durable anti-tumor responses, particularly when targeting multiple antigens to prevent tumor antigen escape. However, increasing CAR complexity…
View article: Graft failure post allogeneic hematopoietic stem cell transplant in pediatric and young adults at a single centre in N. India
Graft failure post allogeneic hematopoietic stem cell transplant in pediatric and young adults at a single centre in N. India Open
Background: Graft failure (GF) is a rare complication post hematopoietic stem cell transplant (HSCT) and failure to achieve a stable engraftment leads to increased risk of morbidity and mortality. Procedure: We performed a retrospective ob…
View article: Blinatumomab-based salvage in relapsed/refractory B-cell acute lymphoblastic leukemia: "real world" experience from a single-centre in India
Blinatumomab-based salvage in relapsed/refractory B-cell acute lymphoblastic leukemia: "real world" experience from a single-centre in India Open
View article: Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity
Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity Open
View article: Long-Term Ovarian Function Assessment After Haematopoietic Stem Cell Transplantation in Female Sickle Cell Anaemia Survivors
Long-Term Ovarian Function Assessment After Haematopoietic Stem Cell Transplantation in Female Sickle Cell Anaemia Survivors Open
Our study highlights the significant impact of HSCT on long-term ovarian function in female SCA survivors. However, further prospective studies with larger sample sizes and longer follow-up periods are required to confirm our findings and …
View article: Improving outcomes of hematopoietic stem cell transplant for leukemia in children and young adults in resource-limited setting
Improving outcomes of hematopoietic stem cell transplant for leukemia in children and young adults in resource-limited setting Open
Introduction: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative approach in patients with relapsed and high-risk leukemia. This retrospective analysis aimed to investigate outcomes and risk factors associated with HSC…
View article: <scp>HLA</scp>‐haploidentical stem cell transplantation in children with inherited bone marrow failure syndromes: A retrospective analysis on behalf of <scp>EBMT</scp> severe aplastic Anemia and pediatric diseases working parties
<span>HLA</span>‐haploidentical stem cell transplantation in children with inherited bone marrow failure syndromes: A retrospective analysis on behalf of <span>EBMT</span> severe aplastic Anemia and pediatric diseases working parties Open
Haploidentical stem cell transplantation (haplo‐SCT) represents the main alternative for children with inherited bone marrow failure syndrome (I‐BMF) lacking a matched donor. This retrospective study, conducted on behalf of the EBMT SAAWP …
View article: Second Salvage Hematopoietic Cell Transplant in a Sickle Cell Disease Presenting with Acquired Hypoplastic Anemia of Donor Marrow
Second Salvage Hematopoietic Cell Transplant in a Sickle Cell Disease Presenting with Acquired Hypoplastic Anemia of Donor Marrow Open
View article: Post-transplant cyclophosphamide as GVHD prophylaxis for peripheral blood stem cell in HLA-related/ unrelated donor HSCT - A new paradigm shift
Post-transplant cyclophosphamide as GVHD prophylaxis for peripheral blood stem cell in HLA-related/ unrelated donor HSCT - A new paradigm shift Open
View article: Incidence, risk factors and outcomes of graft failure post stem cell transplant: Experience from a single tertiary care centre
Incidence, risk factors and outcomes of graft failure post stem cell transplant: Experience from a single tertiary care centre Open
View article: Multimodality, multidisciplinary approach to overcome technical challenges in a pediatric stem cell harvest for sickle cell disease with preformed donor-specific antibodies
Multimodality, multidisciplinary approach to overcome technical challenges in a pediatric stem cell harvest for sickle cell disease with preformed donor-specific antibodies Open
Sickle cell disease is a group of disorders caused by a mutation in the beta chain of hemoglobin (Hb) leading to a vicious cycle of HbS polymerization, increased adhesion-mediated vaso-occlusion and hemolysis-mediated endothelial dysfuncti…
View article: Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells
Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells Open
View article: HLA Identical (Related/Unrelated) Donor Hematopoietic Stem Cell Transplant for Hemoglobinopathies using Pre-transplant Immune Suppression and Post-transplant Cyclophosphamide: Does it Help Consolidate Our Gains?
HLA Identical (Related/Unrelated) Donor Hematopoietic Stem Cell Transplant for Hemoglobinopathies using Pre-transplant Immune Suppression and Post-transplant Cyclophosphamide: Does it Help Consolidate Our Gains? Open
Awaiting gene therapy, hematopoietic stem cell transplant (HSCT) is only curative treatment for Transfusion Dependent Thalassemia (TDT)/Sickle Cell Disease (SCD). Although conventional myeloablative conditioning (MAB) with calcineurin inhi…
View article: NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived Vesicles Open
Circulating cell-free mitochondrial DNA (cf-mtDNA) has been found in the plasma of severely ill COVID-19 patients and is now known as a strong predictor of mortality. However, the underlying mechanism of mtDNA release is unexplored. Here, …
View article: A Simple, Cost-Effective, and Extraction-Free Molecular Diagnostic Test for Sickle Cell Disease Using a Noninvasive Buccal Swab Specimen for a Limited-Resource Setting
A Simple, Cost-Effective, and Extraction-Free Molecular Diagnostic Test for Sickle Cell Disease Using a Noninvasive Buccal Swab Specimen for a Limited-Resource Setting Open
Sickle cell disease (SCD) is the most prevalent life-threatening blood monogenic disorder. Currently, there is no cure available, apart from bone marrow transplantation. Early and efficient diagnosis of SCD is key to disease management, wh…
View article: A simple, cost-effective and extraction-free molecular diagnostic test for sickle cell disease in noninvasive buccal swab specimen for a limited-resource setting
A simple, cost-effective and extraction-free molecular diagnostic test for sickle cell disease in noninvasive buccal swab specimen for a limited-resource setting Open
Sickle cell disease (SCD) is the most prevalent life threatening blood monogenic disorder. Currently, there is no cure available, apart from bone marrow transplantation. Early and efficient diagnosis of SCD is key to disease management whi…
View article: Outcomes of COVID-19 in children with cancer – Report from the Indian Pediatric Oncology Group (InPOG) COVID-19 registry in India
Outcomes of COVID-19 in children with cancer – Report from the Indian Pediatric Oncology Group (InPOG) COVID-19 registry in India Open
INTRODUCTION: The clinical outcomes of COVID-19 infection in children with cancer have been variable worldwide. Therefore, we aimed to collect data from all regions in India through a national collaborative study and identify factors that …
View article: Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of allergic airway inflammation
Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of allergic airway inflammation Open
Mesenchymal stem cell (MSC) transplantation alleviates metabolic defects in diseased recipient cells by intercellular mitochondrial transport (IMT). However, the effect of host metabolic conditions on MSCs in general, and IMT in particular…
View article: Multicenter Outcome of Hematopoietic Stem Cell Transplantation for Primary Immune Deficiency Disorders in India
Multicenter Outcome of Hematopoietic Stem Cell Transplantation for Primary Immune Deficiency Disorders in India Open
Background Hematopoietic stem cell transplantation (HSCT) is the curative option for many primary immune deficiency disorders (PID). In the last 5 years, increased awareness, availability of diagnostics based on flow cytometry, genetic tes…
View article: Survey on Usage of Weekly Hydroxychloroquine Prophylaxis against COVID19 amongst Healthcare Workers in India
Survey on Usage of Weekly Hydroxychloroquine Prophylaxis against COVID19 amongst Healthcare Workers in India Open
To the editor: Covid19 pandemic started in Dec 2019 and has affected >10 million people (1). Despite usage of personal protective equipment many healthcare workers (HCW) have been affected globally with Covid19 and some have died (2-4). We…
View article: Successful T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplant For a Novel NF-E2 Mutation Causing Inherited Thrombocytopenia
Successful T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplant For a Novel NF-E2 Mutation Causing Inherited Thrombocytopenia Open
View article: Hematopoietic Stem Cell Transplant for Osteopetrosis (TCIRG1) Mutation Using Thiotepa Treosulfan Fludarabine Conditioning: Brief Report
Hematopoietic Stem Cell Transplant for Osteopetrosis (TCIRG1) Mutation Using Thiotepa Treosulfan Fludarabine Conditioning: Brief Report Open
Osteopetrosis (OP) is rare metabolic bone disease characterized by impaired osteoclastic bone resorption. It is inherited by autosomal dominant or recessive mode, with variable penetrance, resulting in variable severity. It can present wit…
View article: Capacity Building for Pediatric Blood & Marrow Transplantation in India through Mentorship, Training Programs & International Collaboration
Capacity Building for Pediatric Blood & Marrow Transplantation in India through Mentorship, Training Programs & International Collaboration Open
IntroductionIn 2005, India had less than 10 bone marrow transplant (BMT) centres, mostly adult BMT programs performing 300 BMT/year. There was a need to train more doctors in pediatric BMT and set up more BMT centres focussing on pediatric…
View article: Peripheral Blood Stem Cell Collection on Day 4 Is Feasible and Safe in a Majority of Allogeneic Stem Cell Transplant Donors
Peripheral Blood Stem Cell Collection on Day 4 Is Feasible and Safe in a Majority of Allogeneic Stem Cell Transplant Donors Open
Peripheral blood stem cells (PBSCs) are the most common stem cell source in allogeneic stem cell transplants (ASCT). Most common protocols harvest stem cells on day 5 of G-CSF mobilization. There are limited reports of successful stem cell…
View article: Rhizopus Laryngitis Post Allogenic Stem Cell Transplantation
Rhizopus Laryngitis Post Allogenic Stem Cell Transplantation Open
Invasive Fungal Infections (IFI) are an important complication and constitute significantly to mortality and morbidity, post Hematopoietic Stem Cell Transplant (HSCT). We report a very rare case of fungal laryngitis post HSCT in a 15-year-…
View article: Allogenic hematopoeitic stem cell transplant for high risk acute pediatric leukemia: Single center experience
Allogenic hematopoeitic stem cell transplant for high risk acute pediatric leukemia: Single center experience Open
View article: Hematopoietic stem cell transplant for Hurler’s disease: A Case Report
Hematopoietic stem cell transplant for Hurler’s disease: A Case Report Open
View article: Bone marrow transplant for Recessive Dystrophic Epidermolysis Bullosa: A case report
Bone marrow transplant for Recessive Dystrophic Epidermolysis Bullosa: A case report Open
View article: Hematopoietic Stem Cell Transplant in Elderly Patients: Experience from a Tertiary Care Centre in Northern India
Hematopoietic Stem Cell Transplant in Elderly Patients: Experience from a Tertiary Care Centre in Northern India Open
View article: An unusual cause of anemia and encephalopathy
An unusual cause of anemia and encephalopathy Open
The authors present here an interesting case of recent onset anemia that was associated with an encephalopathy of the unusual cause.Although severe anemia can theoretically result in anemic hypoxia and can then lead to hypoxic encephalopat…