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View article: Knowledge, perception and awareness associated with symptoms and complications of polycystic ovarian syndrome among college women
Knowledge, perception and awareness associated with symptoms and complications of polycystic ovarian syndrome among college women Open
Background: This study aimed to assess the knowledge, perception, and awareness of polycystic ovarian syndrome (PCOS) symptoms and complications among college women’s in Chennai, India, to identify gaps in understanding and inform targeted…
View article: Es könnte so sein, aber auch anders
Es könnte so sein, aber auch anders Open
We would like to thank our colleagues Laxy and Emmert-Fees for their balanced and careful presentation of a contrary view ("Evidence on the health effect of sugar-sweetened beverages and their taxation: Why it is worth taking a really clos…
View article: Fungal infection among patients with chronic rhinosinusitis who underwent endoscopic sinus surgery
Fungal infection among patients with chronic rhinosinusitis who underwent endoscopic sinus surgery Open
Background: Chronic rhinosinusitis (CRS) involves persistent inflammation of the nasal passages and sinuses, often attributed to Aspergillus species as a primary etiological agent. Effective treatment involves complete eradication of funga…
View article: The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress
The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress Open
An elevated frequency of DNA replication defects is associated with diabetes and cancer. However, data linking these nuclear perturbations to the onset or progression of organ complications remained unexplored. Here, we report that RAGE (R…
View article: Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study
Six-Month Periodic Fasting in Patients With Type 2 Diabetes and Diabetic Nephropathy: A Proof-of-Concept Study Open
Context Novel fasting interventions have gained scientific and public attention. Periodic fasting has emerged as a dietary modification promoting beneficial effects on metabolic syndrome. Objective Assess whether periodic fasting reduces a…
View article: A Fast and Reliable Method to Generate Pure, Single Cell-derived Clones of Mammalian Cells
A Fast and Reliable Method to Generate Pure, Single Cell-derived Clones of Mammalian Cells Open
Stable cell cloning is an essential aspect of biological research. All advanced genome editing tools rely heavily on stable, pure, single cell-derived clones of genetically engineered cells. For years, researchers have depended on single-c…
View article: A six-month periodic fasting reduces microalbuminuria and improves metabolic control in patients with type 2 diabetes and diabetic nephropathy: a randomized controlled study
A six-month periodic fasting reduces microalbuminuria and improves metabolic control in patients with type 2 diabetes and diabetic nephropathy: a randomized controlled study Open
Aim Novel dietary interventions focused on fasting, have gained scientific and public attention. Periodic fasting has emerged as a dietary modification promoting beneficial effects on metabolic syndrome. This study aimed to assess whether …
View article: Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations Open
Patients with diabetes are over-represented among the total cases reported with “idiopathic” pulmonary fibrosis (IPF). This raises the question, whether this is an association only or whether diabetes itself can cause pulmonary fibrosis. R…
View article: A laser-mediated photo-manipulative toolbox for generation and real-time monitoring of DNA lesions
A laser-mediated photo-manipulative toolbox for generation and real-time monitoring of DNA lesions Open
With the advancement of laser-based microscopy tools, it is now possible to explore mechano-kinetic processes occurring inside the cell. Here, we describe the advanced protocol for studying the DNA repair kinetics in real time using the la…
View article: Elevated Expression of the RAGE Variant-V in SCLC Mitigates the Effect of Chemotherapeutic Drugs
Elevated Expression of the RAGE Variant-V in SCLC Mitigates the Effect of Chemotherapeutic Drugs Open
Small cell lung carcinoma (SCLC) is a highly aggressive malignancy with a very high mortality rate. A prominent part of this is because these carcinomas are refractory to chemotherapies, such as etoposide or cisplatin, making effective tre…
View article: A Germline Mutation in the POT1 Gene Is a Candidate for Familial Non-Medullary Thyroid Cancer
A Germline Mutation in the POT1 Gene Is a Candidate for Familial Non-Medullary Thyroid Cancer Open
Non-medullary thyroid cancer (NMTC) is a common endocrine malignancy with a genetic basis that has yet to be unequivocally established. In a recent whole-genome sequencing study of five families with occurrence of NMTCs, we shortlisted pro…
View article: A novel germline mutation in the<i>POT1</i>gene predisposes to familial non-medullary thyroid cancer
A novel germline mutation in the<i>POT1</i>gene predisposes to familial non-medullary thyroid cancer Open
Non-medullary thyroid cancer (NMTC) is a common endocrine malignancy with a genetic basis that has yet to be unequivocally established. In a recent whole genome sequencing study of five families with recurrence of NMTCs, we shortlisted pro…
View article: Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair
Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair Open
The integrity of genome is a prerequisite for healthy life. Indeed, defects in DNA repair have been associated with several human diseases, including tissue-fibrosis, neurodegeneration and cancer. Despite decades of extensive research, the…
View article: Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function Open
Coagulation proteases have increasingly recognized functions beyond hemostasis and thrombosis. Disruption of activated protein C (aPC) or insulin signaling impair function of podocytes and ultimately cause dysfunction of the glomerular fil…