Gautier Bréville
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View article: Pro‐Inflammatory <scp>c</scp>‐Met<sup>+</sup><scp>CD4</scp> T Cells in Multiple Sclerosis
Pro‐Inflammatory <span>c</span>‐Met<sup>+</sup><span>CD4</span> T Cells in Multiple Sclerosis Open
Objective Hepatocyte growth factor (HGF) binds exclusively the c‐Met surface receptor, and the HGF/c‐Met axis regulates T cell function in autoimmune diseases. We analyzed c‐Met expression on human CD4 T cells in the blood and cerebrospina…
View article: Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders
Pediatric cerebrospinal fluid immune profiling distinguishes pediatric-onset multiple sclerosis from other pediatric-onset acute neurological disorders Open
The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights into immune processes associated with both healthy immune surveillance as well as inflammatory disorders of the C…
View article: The combination of CSF neurofilament light chain and glial fibrillary acidic protein improves the prediction of long-term confirmed disability worsening in multiple sclerosis
The combination of CSF neurofilament light chain and glial fibrillary acidic protein improves the prediction of long-term confirmed disability worsening in multiple sclerosis Open
Our objective was to evaluate the individual and combined prognostic attributes of baseline serum and CSF measurements of Neurofilament light chain (sNfL, cNfL) and glial fibrillary acidic protein (sGFAP, cGFAP) on long term clinical outco…
View article: Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection
Systemic cytokines related to memory function 6–9 months and 12–15 months after SARS-CoV-2 infection Open
Cognitive symptoms persisting beyond the acute phase of COVID-19 infection are commonly described for up to 2 years after infection. The relationship between cognitive performance, in particular episodic memory processes observed chronical…
View article: CYSTOID MACULAR EDEMA IN BIRDSHOT RETINOCHOROÏDITIS
CYSTOID MACULAR EDEMA IN BIRDSHOT RETINOCHOROÏDITIS Open
Purpose: To assess the long-term efficacy and safety of treatments for cystoid macular edema in birdshot retinochoroïditis. Methods: Observational retrospective study of 142 HLA-A29-positive patients with cystoid macular edema; the main ou…
View article: Impact of inflammatory response in the acute phase of COVID-19 on predicting objective and subjective post-COVID fatigue
Impact of inflammatory response in the acute phase of COVID-19 on predicting objective and subjective post-COVID fatigue Open
The biological predictors of objective and subjective fatigue in individuals with post-COVID syndrome remains unclear. This study aims to ascertain the predictive significance of the immune response measured during the acute phase of SARS-…
View article: Systemic cytokines related to cognitive function 6-9 months and 12-15 months after SARS- CoV-2 infection
Systemic cytokines related to cognitive function 6-9 months and 12-15 months after SARS- CoV-2 infection Open
Background. Cognitive symptoms persisting beyond the acute phase of COVID-19 infection are commonly described for up to 1 year after infection. The relationship between cognitive performance, in particular episodic memory processes observe…
View article: High-dose glucocorticoids in COVID-19 patients with acute encephalopathy: clinical and imaging findings in a retrospective cohort study
High-dose glucocorticoids in COVID-19 patients with acute encephalopathy: clinical and imaging findings in a retrospective cohort study Open
Objectives Acute encephalopathy (AE) has been described as a severe complication of COVID-19. Inflammation has been suggested as a pathogenic mechanism, with high-dose glucocorticoids (GC) showing a beneficial effect. Here, we retrospectiv…
View article: c-Met+ Cytotoxic T Lymphocytes Exhibit Enhanced Cytotoxicity in Mice and Humans In Vitro Tumor Models
c-Met+ Cytotoxic T Lymphocytes Exhibit Enhanced Cytotoxicity in Mice and Humans In Vitro Tumor Models Open
CD8+ cytotoxic T lymphocytes (CTLs) play a crucial role in anti-tumor immunity. In a previous study, we identified a subset of murine effector CTLs expressing the hepatocyte growth factor (HGF) receptor, c-Met (c-Met+ CTLs), that are endow…
View article: C-met+ CTLs Exhibit Enhanced Cytotoxicity in Mouse and Human In Vitro Tumor Models
C-met+ CTLs Exhibit Enhanced Cytotoxicity in Mouse and Human In Vitro Tumor Models Open
CD8+ cytotoxic T lymphocytes (CTLs) play a crucial role in anti-tumor immunity. In a previous study, we identified a subset of murine effector CTLs expressing the hepatocyte growth factor (HGF) receptor c-Met (c-Met+ CTLs) that are endowed…
View article: Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy?
Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? Open
Background This study evaluates the impact of high risk of obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). Methods Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at th…
View article: Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy?
Obstructive sleep apnea: a major risk factor for COVID-19 encephalopathy? Open
Background This study evaluates the impact of comorbid obstructive sleep apnea (OSA) on coronavirus disease 2019 (COVID-19) acute encephalopathy (AE). Methods Between 3/1/2020 and 11/1/2021, 97 consecutive patients were evaluated at the Ge…
View article: Glucocorticoid withdrawal and glucocorticoid-induced adrenal insufficiency: Study protocol of the randomized controlled «TOASST” (Taper Or Abrupt Steroid STop) multicenter trial
Glucocorticoid withdrawal and glucocorticoid-induced adrenal insufficiency: Study protocol of the randomized controlled «TOASST” (Taper Or Abrupt Steroid STop) multicenter trial Open
Background Despite the widespread use of glucocorticoids in inflammatory and autoimmune disorders, there is uncertainty about the safe cessation of long-term systemic treatment, as data from prospective trials are largely missing. Due to p…
View article: Case Series of Acute Peripheral Neuropathies in Individuals Who Received COVID-19 Vaccination
Case Series of Acute Peripheral Neuropathies in Individuals Who Received COVID-19 Vaccination Open
Background and Objectives: Vaccination has been critical to managing the COVID-19 pandemic. Autoimmunity of the nervous system, especially among a select set of high-risk groups, can be triggered or enhanced by the contents of vaccines. He…
View article: CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation
CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation Open
Objective c-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate cell migration, maturation, cytokine production, and antigen presentation. Here, we report t…
View article: Monocytosis in the Acute Phase of SARS-CoV-2 Infection Predicts the Presence of Anosognosia for Cognitive Deficits in the Chronic Phase
Monocytosis in the Acute Phase of SARS-CoV-2 Infection Predicts the Presence of Anosognosia for Cognitive Deficits in the Chronic Phase Open
Altered awareness of neuropsychological disorders (i.e., anosognosia) is a striking symptom of post-COVID-19 syndrome. Some leukocytes markers in the acute phase might predict the presence of anosognosia in the chronic phase, but they have…
View article: Omicron-Specific Cytotoxic T-Cell Responses After a Third Dose of mRNA COVID-19 Vaccine Among Patients With Multiple Sclerosis Treated With Ocrelizumab
Omicron-Specific Cytotoxic T-Cell Responses After a Third Dose of mRNA COVID-19 Vaccine Among Patients With Multiple Sclerosis Treated With Ocrelizumab Open
In this cohort study of patients with MS treated with ocrelizumab, there were robust T-cell responses recognizing spike proteins from the Delta and Omicron variants, suggesting that COVID-19 vaccination in patients taking B-cell-depleting …
View article: Intrathecal Synthesis Index of Specific Anti- <i>Treponema</i> IgG: a New Tool for the Diagnosis of Neurosyphilis
Intrathecal Synthesis Index of Specific Anti- <i>Treponema</i> IgG: a New Tool for the Diagnosis of Neurosyphilis Open
In the context of a lack of a gold standard for the diagnosis of neurosyphilis due to either nonspecific or nonsensitive tests, we present in this article a new promising tool highly specific for NS diagnosis. This new test involves measur…
View article: Short-term glucocorticoid-related side effects and adverse reactions: a narrative review and practical approach
Short-term glucocorticoid-related side effects and adverse reactions: a narrative review and practical approach Open
Glucocorticoids are the mainstay treatment of a variety of inflammatory and autoimmune disorders. Unfortunately, metabolic side effects, drug interactions and adverse reactions commonly lead to glucocorticoid-related side effects, thereby …
View article: Omicron-specific cytotoxic T-cell responses are boosted following a third dose of mRNA COVID-19 vaccine in anti-CD20-treated multiple sclerosis patients
Omicron-specific cytotoxic T-cell responses are boosted following a third dose of mRNA COVID-19 vaccine in anti-CD20-treated multiple sclerosis patients Open
Importance The SARS-CoV-2 variant Omicron escapes neutralizing antibody responses elicited after COVID-19 vaccination, while T-cell responses might be better conserved. It is crucial to assess how a third dose of vaccination modifies these…
View article: Robust T-Cell Responses in Anti-CD20-Treated Patients Following COVID-19 Vaccination: A Prospective Cohort Study
Robust T-Cell Responses in Anti-CD20-Treated Patients Following COVID-19 Vaccination: A Prospective Cohort Study Open
Background Patients treated with anti-CD20 therapy are particularly at risk of developing severe coronavirus disease 2019 (COVID-19); however, little is known regarding COVID-19 vaccine effectiveness in this population. Methods This prospe…
View article: C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy
C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy Open
Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic inflammation and brain microstructural changes (measured by diffusion-weighted imaging) in patie…
View article: Patients treated with anti-CD20 therapy can mount robust T cell responses to mRNA-based COVID-19 vaccines
Patients treated with anti-CD20 therapy can mount robust T cell responses to mRNA-based COVID-19 vaccines Open
Patients treated with anti-CD20 therapy are particularly at risk of developing severe COVID-19, however little is known regarding COVID-19 vaccine effectiveness in this population. This study assesses humoral and T-cell responses to mRNA-b…