Gavin S.W. Chan
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View article: Human germline heterozygous gain-of-function <i>STAT6</i> variants cause severe allergic disease
Human germline heterozygous gain-of-function <i>STAT6</i> variants cause severe allergic disease Open
STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation. We have identified 16 patients from 10 families spanning three continents with …
View article: Clinical Outcomes and Clinico-pathological Correlations in Lupus Nephritis with Kidney Biopsy Showing Thrombotic Microangiopathy
Clinical Outcomes and Clinico-pathological Correlations in Lupus Nephritis with Kidney Biopsy Showing Thrombotic Microangiopathy Open
Objective. Renal thrombotic microangiopathy (TMA) is an uncommon pathological finding in lupus nephritis (LN), and its clinical significance remains to be defined. Methods. Twenty-four patients with lupus nephritis (LN) and renal TMA were …
View article: Significance of small anteromedial or subpulmonic pneumothoraces on admission chest radiographs in late preterm/term neonates
Significance of small anteromedial or subpulmonic pneumothoraces on admission chest radiographs in late preterm/term neonates Open
Purpose: To determine whether subtle anteromedial or subpulmonic pneumothorax (PTX) on neonatal admission chest radiograph is associated with depressed Apgar scores and significant resuscitation. Methods: Retrospective review of 375 neonat…