Gavin O’Connor
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View article: Analytical practices, use and needs of standard and reference materials in the German-speaking metabolomics community: results of an online survey
Analytical practices, use and needs of standard and reference materials in the German-speaking metabolomics community: results of an online survey Open
Introduction Since the early 2000s, metabolomics has grown rapidly, becoming integral to fields like life sciences, health, and environmental research. This expansion has led to the formation of national and international societies, such a…
View article: Cross-linking mass spectrometry for structure analysis of the intrinsically disordered Tau and phosphorylated Tau protein
Cross-linking mass spectrometry for structure analysis of the intrinsically disordered Tau and phosphorylated Tau protein Open
We present a novel method for analyzing the folding of intrinsically disordered proteins (IDPs), such as Tau and phosphorylated Tau (pTau), in solution. Using cross-linking mass spectrometry combined with a new downstream analysis framewor…
View article: Flow cytometer for a dilution-free measurement approach with sample recollection
Flow cytometer for a dilution-free measurement approach with sample recollection Open
Blood testing using flow cytometry is a common and rapid method for the initial screening and diagnosis of patients. Measurements are often combined with other scientific techniques, and analyzed samples are commonly diluted and discarded …
View article: AB167. SOH23ABS_136. To investigate if preoperative anaemia in patients undergoing hip arthroplasty is associated with postoperative blood transfusions
AB167. SOH23ABS_136. To investigate if preoperative anaemia in patients undergoing hip arthroplasty is associated with postoperative blood transfusions Open
Background: Approximately 7,000 total hip arthroplasty (THA) surgeries occur in Ireland each year. Anaemia is a common condition in this population who undergo THA. Blood transfusions are commonly used to treat low haemoglobin secondary to…
View article: Label-free Quantification of Host-Cell Protein Impurity in a Recombinant Hemoglobin Reference Material
Label-free Quantification of Host-Cell Protein Impurity in a Recombinant Hemoglobin Reference Material Open
Quantitativ e analysis depends on pure-substance primary calibrators with known mass fractions of impurity. Here, label-free quantification (LFQ) is being evaluated as a readily available, reliable method for determining the mass fraction …
View article: Comparing 13C methyl and deuterated methyl isotopic labeling for the quantification of methyl cellulose patterns using mass spectrometry
Comparing 13C methyl and deuterated methyl isotopic labeling for the quantification of methyl cellulose patterns using mass spectrometry Open
The methyl substitution along and among the polymer chains of methyl cellulose (MC) is commonly analyzed by ESI-MS after perdeuteromethylation of the free-OH groups and partial hydrolysis to cello-oligosaccharides (COS). This method requir…
View article: A reference method for determining the total allergenic protein content in a processed food: the case of milk in cookies as proof of concept
A reference method for determining the total allergenic protein content in a processed food: the case of milk in cookies as proof of concept Open
The establishment of a reference method for the determination of the allergen protein content in a processed food material has been explored. An analytical approach was developed to enable the comparability of food allergen measurement res…
View article: Review on Proteomics for Food Authentication *
Review on Proteomics for Food Authentication * Open
Food products can be deliberately substituted, partially or entirely, with similar, lower quality, and cheaper counterparts or unintentional errors can cause inadvertent mislabeling of products. The adulteration of food products is a major…
View article: Design, manufacture and test of a high temperature tensile and compression testing device
Design, manufacture and test of a high temperature tensile and compression testing device Open
This paper describes the design and manufacture of a low-cost laboratory test device capable of testing metallic materials at elevated temperatures. The device, which consists of an environmental chamber, specimen gripping mechanism, and a…
View article: The feasibility of harmonizing gluten ELISA measurements
The feasibility of harmonizing gluten ELISA measurements Open
Many publications have highlighted that routine ELISA methods do not give rise to equivalent gluten content measurement results. In this study, we assess this variation between results and its likely impact on the enforcement of the EU glu…
View article: Label‐Free Proteomic Analysis of Wheat Gluten Proteins and Their Immunoreactivity to ELISA Antibodies
Label‐Free Proteomic Analysis of Wheat Gluten Proteins and Their Immunoreactivity to ELISA Antibodies Open
Enzyme‐linked immunosorbent assay (ELISA) methods are currently the most widely used for gluten quantification. However, the lack of comparable measurements among commercial kits has caused much concern. Here, we studied the immunoreactivi…
View article: Review on proteomics for food authentication
Review on proteomics for food authentication Open
This review paper provides a comprehensive and critical overview of the application of proteomics approaches to determine the authenticity of several food products updating the performances and current limitations of the applied techniques…
View article: Defining the wheat gluten peptide fingerprint via a discovery and targeted proteomics approach
Defining the wheat gluten peptide fingerprint via a discovery and targeted proteomics approach Open
The measurement of gluten in processed food products in support of regulatory limits is performed routinely. Mass spectrometry is emerging as a viable alternative to ELISA based methods. Here we outline a set of peptide markers that are re…