Gavin W. Roddy
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View article: Optimizing procedures for ocular radiation injury studies in the tree shrew
Optimizing procedures for ocular radiation injury studies in the tree shrew Open
Radiation exposure to the eye during cancer treatment can lead to ocular radiation injury (ORI), a devastating condition that can have a profound and permanent impact on vision-related quality of life. Rodent models do not have adequate oc…
View article: Evaluating the association between autoimmune disease and normal tension glaucoma: a retrospective case-control study
Evaluating the association between autoimmune disease and normal tension glaucoma: a retrospective case-control study Open
Our study found no significant association between autoimmune disease and NTG, suggesting that other factors may play a more significant role in the pathogenesis of NTG.
View article: Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches
Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches Open
Intraocular pressure (IOP) elevation is the primary risk factor and currently the main treatable factor for progression of glaucomatous optic neuropathy. In addition to direct clinical and living animal in vivo studies, ex vivo perfusion o…
View article: Subconjunctival Administration of an Adeno-Associated Virus Expressing Stanniocalcin-1 Provides Sustained Intraocular Pressure Reduction in Mice
Subconjunctival Administration of an Adeno-Associated Virus Expressing Stanniocalcin-1 Provides Sustained Intraocular Pressure Reduction in Mice Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Appropriateness of Ophthalmology Recommendations From an Online Chat-Based Artificial Intelligence Model
Appropriateness of Ophthalmology Recommendations From an Online Chat-Based Artificial Intelligence Model Open
View article: Permanent ocular remodeling in the setting of chronic hypotony after trabeculectomy: A case report
Permanent ocular remodeling in the setting of chronic hypotony after trabeculectomy: A case report Open
View article: Efficacy of Selective Laser Trabeculoplasty in Patients on Systemic Immunosuppressive Therapy
Efficacy of Selective Laser Trabeculoplasty in Patients on Systemic Immunosuppressive Therapy Open
Précis: When comparing patients on systemic immunosuppressive therapy to those without, there was no difference in intraocular pressure (IOP) early after SLT; however, at 1 year following SLT, IOP was higher in the immunosuppression group …
View article: Metabolic syndrome and its components are associated with non-arteritic anterior ischaemic optic neuropathy
Metabolic syndrome and its components are associated with non-arteritic anterior ischaemic optic neuropathy Open
Purpose To determine whether metabolic syndrome (MetS) is a risk factor for various forms of optic neuropathy including non-arteritic anterior ischaemic optic neuropathy (NAION). Methods This population-based analysis identified patients ≥…
View article: Optic Disc Drusen in Patients With Ocular Hypertension: A Case Series and Review of the Literature
Optic Disc Drusen in Patients With Ocular Hypertension: A Case Series and Review of the Literature Open
Background: The identification of glaucomatous optic neuropathy in the setting of optic disc drusen (ODD) is a challenge, and the decision of whether to offer treatment in the form of intraocular pressure (IOP) reduction is controversial. …
View article: Table of Contents
Table of Contents Open
View article: Transgene expression of Stanniocalcin-1 provides sustained intraocular pressure reduction by increasing outflow facility
Transgene expression of Stanniocalcin-1 provides sustained intraocular pressure reduction by increasing outflow facility Open
Glaucoma is the leading cause of irreversible blindness worldwide. Therapies for glaucoma are directed toward reducing intraocular pressure (IOP), the leading risk factor and only reliable therapeutic target via topical medications or with…
View article: Mechanisms of post-radiation optic atrophy with neuroretinal rim thinning
Mechanisms of post-radiation optic atrophy with neuroretinal rim thinning Open
View article: Surgical Advancement of Tenon’s Layer During Trabeculectomy Improves Bleb Morphology
Surgical Advancement of Tenon’s Layer During Trabeculectomy Improves Bleb Morphology Open
Trabeculectomy surgery remains the gold standard incisional glaucoma surgical procedure in many practices, particularly for patients requiring intraocular pressure (IOP) in the low teens or below. However, trabeculectomy surgery is associa…
View article: Angle closure secondary to lens remnants in a patient with presumed aphakia: case report
Angle closure secondary to lens remnants in a patient with presumed aphakia: case report Open
Background Eyes with a short axial length or anterior chamber depth often develop narrowed anterior chamber angles in association with an enlarging crystalline lens. We report a case of a patient who presented in angle closure, with a dist…
View article: Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa
Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa Open
Intravitreal administration of STC-1 enhances cone photoreceptor function, improves EZ integrity, and reduces retinal degeneration through antioxidative and anti-inflammatory effects in a large animal (pig) model of the most common form of…
View article: Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models
Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models Open
ATP-sensitive potassium channel openers CKLP1 and diazoxide effectively decreased the IOP in ocular hypertensive animal models by decreasing the episcleral venous pressure, supporting a potential therapeutic application of these agents in …
View article: Association of Metabolic Syndrome With Glaucoma and Ocular Hypertension in a Midwest United States Population
Association of Metabolic Syndrome With Glaucoma and Ocular Hypertension in a Midwest United States Population Open
Précis: For patients with glaucoma, metabolic syndrome was associated with higher intraocular pressure and greater central corneal thickness. Patients with metabolic syndrome were more likely to have ocular hypertension. Purpose: The purpo…
View article: Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma
Multiple Systemic Vascular Risk Factors Are Associated With Low-Tension Glaucoma Open
Précis: Multiple systemic vascular-associated conditions including systemic hypertension and hypotension, diabetes mellitus, migraine headache, peripheral vascular disease, Raynaud syndrome, and anemia were associated with low-tension glau…
View article: Stanniocalcin-1 Reduced Intraocular Pressure in Two Models of Ocular Hypertension
Stanniocalcin-1 Reduced Intraocular Pressure in Two Models of Ocular Hypertension Open
Purpose/Aim: Glaucomatous optic neuropathy (GON) remains the world's leading cause of irreversible blindness. Treatments including topical medications are directed at reducing intraocular pressure (IOP), the most significant risk fa…
View article: Recurrent, Delayed-Onset Hyphema Following iStent Inject Managed With Device Removal: A Case Report
Recurrent, Delayed-Onset Hyphema Following iStent Inject Managed With Device Removal: A Case Report Open
Minimally invasive glaucoma surgeries have become increasingly popular in recent years, with the iStent Inject trabecular micro-bypass device (Glaukos, Laguna Hills, CA) being a well-tolerated treatment option for mild to moderate glaucoma…
View article: Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction
Stanniocalcin-1 (STC-1), a downstream effector molecule in latanoprost signaling, acts independent of the FP receptor for intraocular pressure reduction Open
Prostaglandin F2 alpha (PGF2α) analogues such as latanoprost are common first-line intraocular pressure (IOP) lowering medications. However, their clinical use is limited in some patient populations due to minimal or no IOP lowering respon…
View article: Diet Mimicking “Fast Food” Causes Structural Changes to the Retina Relevant to Age-Related Macular Degeneration
Diet Mimicking “Fast Food” Causes Structural Changes to the Retina Relevant to Age-Related Macular Degeneration Open
Introduction: Metabolic syndrome is a disorder characterized by a constellation of findings including truncal obesity, elevated blood pressure, abnormal cholesterol levels, and high blood glucose. Recent evidence suggests that metab…
View article: Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity
Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity Open
Abnormal activation of signaling pathways related to angiogenesis, inflammation, and oxidative stress has been implicated in the pathophysiology of retinopathy of prematurity (ROP), a leading cause of blindness in pre-term infants. Therapi…
View article: Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity
Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity Open
Abnormal activation of signaling pathways related to angiogenesis, inflammation, and oxidative stress has been implicated in the pathophysiology of retinopathy of prematurity (ROP), a leading cause of blindness in pre-term infants. Therapi…
View article: Long-term photoreceptor rescue in two rodent models of retinitis pigmentosa by adeno-associated virus delivery of Stanniocalcin-1
Long-term photoreceptor rescue in two rodent models of retinitis pigmentosa by adeno-associated virus delivery of Stanniocalcin-1 Open
View article: Glaucoma drainage device and trabeculectomy surgery is associated with a higher rate of post-operative blepharoptosis compared to cataract extraction in a prospective cohort
Glaucoma drainage device and trabeculectomy surgery is associated with a higher rate of post-operative blepharoptosis compared to cataract extraction in a prospective cohort Open
View article: Optic Nerve Gray Crescent
Optic Nerve Gray Crescent Open
View article: Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost
Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost Open
Latanoprost-induced reduction of IOP is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties.