Gavin Walker
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View article: The Carbon at Risk measure can unlock financial markets for large-scale carbon removal
The Carbon at Risk measure can unlock financial markets for large-scale carbon removal Open
In carbon removal markets, binary classifications like ‘permanent’ versus ‘non-permanent’ have emerged as practical heuristics but discourage investment just when we need it most. Drawing inspiration from Value at Risk in financial markets…
View article: Novel Hybrid ANN-Interpolation Techniques for Predicting Mean Residence Time in Wet Twin Screw Granulation Application: A Critical Review
Novel Hybrid ANN-Interpolation Techniques for Predicting Mean Residence Time in Wet Twin Screw Granulation Application: A Critical Review Open
In twin-screw granulation (TSG), the mean residence time (MRT) of materials significantly influences granule properties, such as size distribution and density, impacting the quality of the final product. Accurately estimating MRT is crucia…
View article: Water skills for life: assessing population-level coverage of a school-based aquatic program in Aotearoa, New Zealand
Water skills for life: assessing population-level coverage of a school-based aquatic program in Aotearoa, New Zealand Open
Continued investment and participation in population-level water survival programs that are available to all societal groups will increase water safety and reduce drowning rates. There is a need to ensure investment keeps pace with changin…
View article: Sustainable and novel approaches for bioactive compound extraction: Development of hydrodynamic cavitation and coupled machine learning-spline techniques for Ascophyllum nodosum and Fucus vesiculosus
Sustainable and novel approaches for bioactive compound extraction: Development of hydrodynamic cavitation and coupled machine learning-spline techniques for Ascophyllum nodosum and Fucus vesiculosus Open
Ascophyllum nodosum and Fucus vesiculosus brown seaweeds are rich in polyphenols, phlorotannins, proteins, and antioxidants, valuable in the food, pharmaceutical, and cosmetic industries. This study compares hydrodynamic cavitation (HC) an…
View article: Orchestrating Visual and Linguistic Modalities for Robust Spatial Intelligence in LVLMs
Orchestrating Visual and Linguistic Modalities for Robust Spatial Intelligence in LVLMs Open
The ability of large vision-language models (LVLMs) to understand and reason about complex spatial relationships within visual scenes is critical for advancing artificial intelligence, particularly in domains like robotics and augmented re…
View article: Merging Real-Time NIR and Process Parameter Measurements in a Fluidized Bed Granulation Process to Predict Particle Size
Merging Real-Time NIR and Process Parameter Measurements in a Fluidized Bed Granulation Process to Predict Particle Size Open
Background/Objectives: Controlling the critical quality attributes (CQAs), such as granule moisture level and particle size distribution, that impact product performance is essential for ensuring product quality in medicine manufacture. Or…
View article: Crystal Shape Factors of Form I Paracetamol
Crystal Shape Factors of Form I Paracetamol Open
In this work, we report the new protocols that are developed to determine the shape factors of Form I paracetamol crystals using a combination of techniques that rely on the state-of-the-art X-ray computed tomography and Morphologi G3. The…
View article: A new and unified semi-analytical method with a convergence acceleration parameter for linear and nonlinear fragmentation equations
A new and unified semi-analytical method with a convergence acceleration parameter for linear and nonlinear fragmentation equations Open
In recent years, turbulent multiphase flows, including bubbles and droplet breakup, have been commonly modelled using linear fragmentation population balance equations (PBEs) to capture droplet distribution effectively. These models often …
View article: A Concept Crystal Habit Phase Diagram and Data for Curcumin in Isopropanol: Classical Versus Non-Classical Crystallization
A Concept Crystal Habit Phase Diagram and Data for Curcumin in Isopropanol: Classical Versus Non-Classical Crystallization Open
Cooling crystallization experiments of curcumin in isopropanol confirmed that curcumin can crystallize via classical or nonclassical pathways, depending on the levels of supersaturation and supercooling. Light microscopy analysis revealed …
View article: Process Analytical Technology Obtained Metastable Zone Width, Nucleation Rate and Solubility of Paracetamol in Isopropanol—Theoretical Analysis
Process Analytical Technology Obtained Metastable Zone Width, Nucleation Rate and Solubility of Paracetamol in Isopropanol—Theoretical Analysis Open
Background: Metastable zone width (MSZW) and solubility are crucial for developing crystallization procedures in the purification of active pharmaceutical ingredients (APIs). Traditionally, determining these properties involves labor-inten…
View article: Designing Continuous Crystallization Protocols for Curcumin Using PAT Obtained Batch Kinetics
Designing Continuous Crystallization Protocols for Curcumin Using PAT Obtained Batch Kinetics Open
Developing theory-informed standard operating procedures (SOPs) for the continuous crystallisation of pharmaceuticals still remains a bottleneck. For the continuous manufacturing of pharmaceuticals, the current methods rely on the laboriou…
View article: Pulmonary Inhalation of Biotherapeutics: A Systematic Approach to Understanding the Effects of Atomisation Gas Flow Rate on Particle Physiochemical Properties and Retained Bioactivity
Pulmonary Inhalation of Biotherapeutics: A Systematic Approach to Understanding the Effects of Atomisation Gas Flow Rate on Particle Physiochemical Properties and Retained Bioactivity Open
The identification of spray-drying processing parameters capable of producing particles suitable for pulmonary inhalation with retained bioactivity underpins the development of inhalable biotherapeutics. Effective delivery of biopharmaceut…
View article: Continuous crystallisation in a superstat: Batch kinetics informed theoretical SOP
Continuous crystallisation in a superstat: Batch kinetics informed theoretical SOP Open
Developing theory informed standard operating procedure (SOP) for the continuous crystallisation of pharmaceuticals remain a bottleneck. In this communication, we propose a theoretical background and mathematics for superstat based on whic…
View article: Application of Raman and chemometrics to the mechanochemical synthesis of 4,4-bipyridine/cobalt based MOF using twin screw extrusion
Application of Raman and chemometrics to the mechanochemical synthesis of 4,4-bipyridine/cobalt based MOF using twin screw extrusion Open
The process optimization of 4,4-bipyridine based metal organic framework (MOF) synthesis by twin screw extrusion (TSE) is investigated using cobalt nitrate hexahydrate (Co(NO3)2⋅6H2O) as the metal precursor. The effects of operating parame…
View article: Pseudo second order kinetic expression to predict the kinetics of the anomalous crystal growth of curcumin in impure solution
Pseudo second order kinetic expression to predict the kinetics of the anomalous crystal growth of curcumin in impure solution Open
Pseudo second order kinetics can accurately predict the crystal growth kinetics.
View article: Particle Breakage Using Wet Mill, Ultrasonic, and Hydrodynamic Cavitation
Particle Breakage Using Wet Mill, Ultrasonic, and Hydrodynamic Cavitation Open
In-line fluidic devices and mills are often used for controlling crystal size distribution during crystallization. In this work, we investigated the breakage of organic crystals in three particle breakage devices. Paracetamol was selected …
View article: Exclusive Human Milk Diet for Extremely Premature Infants: A Novel Fortification Strategy That Enhances the Bioactive Properties of Fresh, Frozen, and Pasteurized Milk Specimens
Exclusive Human Milk Diet for Extremely Premature Infants: A Novel Fortification Strategy That Enhances the Bioactive Properties of Fresh, Frozen, and Pasteurized Milk Specimens Open
Background: Human milk (HM) fortification has been recommended for the nutritional optimization of very low-birthweight infants. This study analyzed the bioactive components of HM and evaluated fortification choices that could accentuate o…
View article: New Discrete Formulation for Reduced Population Balance Equation: An Illustration to Crystallization
New Discrete Formulation for Reduced Population Balance Equation: An Illustration to Crystallization Open
In this paper, we focus on providing a discrete formulation for a reduced aggregation population balance equation. The new formulation is simpler, easier to code, and adaptable to any type of grid. The presented method is extended to addre…
View article: A molecularly enhanced proof of concept for targeting cocrystals at molecular scale in continuous pharmaceuticals cocrystallization
A molecularly enhanced proof of concept for targeting cocrystals at molecular scale in continuous pharmaceuticals cocrystallization Open
Significance This contribution offers a proof of concept to make it possible to target a specific (co)crystal at molecular scale within a continuous process. The paper, while addressing a very important issue in public health, i.e., high-e…
View article: Stabilizing vaccines via drying: Quality by design considerations
Stabilizing vaccines via drying: Quality by design considerations Open
Pandemics and epidemics are continually challenging human beings’ health and imposing major stresses on the societies particularly over the last few decades, when their frequency has increased significantly. Protecting humans from multiple…
View article: Hydroxychloroquine Does Not Function as a Direct Zinc Ionophore
Hydroxychloroquine Does Not Function as a Direct Zinc Ionophore Open
Drug-mediated correction of abnormal biological zinc homeostasis could provide new routes to treating neurodegeneration, cancer, and viral infections. Designing therapeutics to facilitate zinc transport intracellularly is hampered by inade…
View article: Magnetically recyclable Schiff-based palladium nanocatalyst [Fe3O4@SiNSB-Pd] and its catalytic applications in Heck reaction
Magnetically recyclable Schiff-based palladium nanocatalyst [Fe3O4@SiNSB-Pd] and its catalytic applications in Heck reaction Open
A magnetically separable palladium nanocatalyst has been synthesized through the immobilization of palladium onto 3-aminopropylphenanthroline Schiff based functionalized silica coated superparamagnetic Fe3O4 nanoparticles. The nanocatalyst…
View article: Challenges and opportunities in modelling wet granulation in pharmaceutical industry – A critical review
Challenges and opportunities in modelling wet granulation in pharmaceutical industry – A critical review Open
Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms. Wet granulation is used in pharmaceutical production to enhance formulation qualities such as flowability, compressibility, etc. Different methods are…
View article: Formation of Ciprofloxacin–Isonicotinic Acid Cocrystal Using Mechanochemical Synthesis Routes—An Investigation into Critical Process Parameters
Formation of Ciprofloxacin–Isonicotinic Acid Cocrystal Using Mechanochemical Synthesis Routes—An Investigation into Critical Process Parameters Open
The mechanochemical synthesis of cocrystals has been introduced as a promising approach of formulating poorly water-soluble active pharmaceutical ingredients (APIs). In this study, hot-melt extrusion (HME) as a continuous process and grind…