Gavriel Brown
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View article: LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis
LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis Open
Platelet shape and volume changes are early mechanical events contributing to platelet activation and thrombosis. Here, we identify single-nucleotide polymorphisms in leucine-rich repeat–containing 8 (LRRC8) protein subunits that form the …
View article: LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis
LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis Open
Platelet shape and volume changes are early mechanical events contributing to platelet activation and thrombosis. Here, we identify single-nucleotide polymorphisms in Leucine-Rich Repeat Containing 8 (LRRC8) protein subunits that form the …
View article: A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke
A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke Open
Background: Platelet adhesion and aggregation play a crucial role in arterial thrombosis and ischemic stroke. Here, we identify platelet ERO1α (endoplasmic reticulum oxidoreductase 1α) as a novel regulator of Ca 2+ signaling and a potentia…