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View article: Quality of life and functional outcomes after rectal sparing approaches following neoadjuvant therapy for rectal cancer: a prospective cohort multicentre study
Quality of life and functional outcomes after rectal sparing approaches following neoadjuvant therapy for rectal cancer: a prospective cohort multicentre study Open
Background: This prospective observational multicenter cohort study aimed to establish the functional outcomes and quality of life (QoL) of patients with rectal cancer who showed a major (mCR) or complete clinical response (cCR) after neoa…
View article: CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming
CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming Open
Background Colorectal cancer (CRC) progression is shaped by the tumor microenvironment, particularly tumor-associated macrophages (TAMs), which often adopt immunosuppressive functions. CD300e, a myeloid receptor involved in immune regulati…
View article: Incidence of non-colorectal/endometrial malignancies in individuals with Lynch syndrome: a retrospective cohort study
Incidence of non-colorectal/endometrial malignancies in individuals with Lynch syndrome: a retrospective cohort study Open
Summary: Background: Lynch syndrome (LS) is strongly associated with colorectal (CRC) and endometrial (EC) cancers, for which Universal Tumor Screening (UTS) via mismatch repair proteins (MMRs) immunohistochemistry is currently recommended…
View article: Textbook oncologic outcomes in elderly patients undergoing neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer: a multicenter study
Textbook oncologic outcomes in elderly patients undergoing neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer: a multicenter study Open
Standard treatment of locally advanced rectal cancer (LARC) involves neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME). However, in older patients, comorbidities and frailty may limit the feasibility of this …
View article: Distinct microbiota composition and dendritic cell activation in the appendix microenvironment of ulcerative colitis patients
Distinct microbiota composition and dendritic cell activation in the appendix microenvironment of ulcerative colitis patients Open
Appendectomy has been associated with reduced risk of developing ulcerative colitis (UC) or experiencing flares after diagnosis, suggesting the appendix may play a role in UC pathogenesis. Given its function in microbial homeostasis and gu…
View article: A patient-derived decellularized extracellular matrix hydrogel as a biomimetic scaffold for advanced 3D colorectal cancer modeling
A patient-derived decellularized extracellular matrix hydrogel as a biomimetic scaffold for advanced 3D colorectal cancer modeling Open
Colorectal cancer (CRC) is among the most prevalent cancers globally and is associated with a high mortality rate, particularly in advanced stages. In the realm of drug discovery, the use of innovative and highly translational pre-clinical…
View article: The Role of KRAS Status Among Patients Undergoing Staged Versus Simultaneous Resection for Synchronous Colorectal Liver Metastases
The Role of KRAS Status Among Patients Undergoing Staged Versus Simultaneous Resection for Synchronous Colorectal Liver Metastases Open
Background This study aimed to evaluate the impact of surgical timing—simultaneous versus staged resection—on outcomes of patients with colorectal liver metastases (CRLM) in relation to KRAS mutation status, which is a key factor affecting…
View article: Quality of Life in Rectal Cancer Treatments: An Updated Systematic Review of Randomized Controlled Trials (2013–2023)
Quality of Life in Rectal Cancer Treatments: An Updated Systematic Review of Randomized Controlled Trials (2013–2023) Open
Background: Rectal cancer management involves surgery, chemotherapy (CT), radiotherapy (RT), and patient care strategies, all of which significantly affect health-related quality of life (HRQoL). Understanding these effects is critical for…
View article: Pan-immune-inflammation in colon cancer: A prognostic biomarker and the role of tumor location in personalized care
Pan-immune-inflammation in colon cancer: A prognostic biomarker and the role of tumor location in personalized care Open
Despite advances in surgery, chemotherapy, and radiotherapy, the treatment of colorectal cancer (CRC) requires more personalized approaches based on tumor biology and molecular profiling. While some relevant mutations have been associated …
View article: Circulating Tumor DNA as a Real-Time Biomarker for Minimal Residual Disease and Recurrence Prediction in Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis
Circulating Tumor DNA as a Real-Time Biomarker for Minimal Residual Disease and Recurrence Prediction in Stage II Colorectal Cancer: A Systematic Review and Meta-Analysis Open
The role of adjuvant chemotherapy (adj-CT) in stage II colon cancer remains controversial. Circulating tumor DNA (ctDNA) is a promising biomarker for detecting minimal residual disease (MRD) and predicting recurrence. This systematic revie…
View article: Announcement of Consensus Conference on Definitions of Artificial Intelligence for the Next Generation of Surgeons
Announcement of Consensus Conference on Definitions of Artificial Intelligence for the Next Generation of Surgeons Open
This editorial announces the need for a consensus conference on definitions of surgical nomenclature, which is evolving due to the introduction of non-human (hardware, software) devices and applications, including robotics. A recently crea…
View article: Machine learning and deep learning to improve prevention of anastomotic leak after rectal cancer surgery
Machine learning and deep learning to improve prevention of anastomotic leak after rectal cancer surgery Open
Anastomotic leakage (AL) is a significant complication following rectal cancer surgery, adversely affecting both quality of life and oncological outcomes. Recent advancements in artificial intelligence (AI), particularly machine learning a…
View article: Bayesan Model to Predict R Status After Neoadjuvant Therapy in Pancreatic Cancer
Bayesan Model to Predict R Status After Neoadjuvant Therapy in Pancreatic Cancer Open
Objective: To build a Bayesian approach-based model to predict the success of surgical exploration post-neoadjuvant treatment. Background: Pancreatic cancer (PDAC) is best treated with radical surgery and chemotherapy, offering the greates…
View article: A Machine Learning Model Based on MRI Radiomics to Predict Response to Chemoradiation Among Patients with Rectal Cancer
A Machine Learning Model Based on MRI Radiomics to Predict Response to Chemoradiation Among Patients with Rectal Cancer Open
Background: With rectum-sparing protocols becoming more common for rectal cancer treatment, this study aimed to predict the pathological complete response (pCR) to preoperative chemoradiotherapy (pCRT) in rectal cancer patients using pre-t…
View article: Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative Group
Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative Group Open
Objective: The aim of this study is to provide solid evidence to update the management of stage I colon cancer (CC) after surgery. Background: Given the low risk of recurrence of stage I CC, some international guidelines do not recommend i…
View article: Oral administration of <i>Lactobacillus casei</i> DG® after ileostomy closure in restorative proctocolectomy: a randomized placebo-controlled trial (microbiota and immune microenvironment in pouchitis -MEP1)
Oral administration of <i>Lactobacillus casei</i> DG® after ileostomy closure in restorative proctocolectomy: a randomized placebo-controlled trial (microbiota and immune microenvironment in pouchitis -MEP1) Open
Pouchitis is an idiopathic inflammatory disease that may occur in ileal pouches, and it can lead to ileal pouch failure. This was a single-center, randomized, double-blinded, placebo-controlled trial that assessed the effect of Lactobacill…
View article: Application and use of artificial intelligence in colorectal cancer surgery: where are we?
Application and use of artificial intelligence in colorectal cancer surgery: where are we? Open
AI is revolutionizing the landscape of colorectal cancer (CRC) surgery, permeating diverse facets ranging from intraoperative guidance to predictive modeling of postoperative outcomes. This scoping review aims to comprehensively delineate …
View article: CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming
CD300e is a driver of the immunosuppressive tumor microenvironment and colorectal cancer progression via macrophage reprogramming Open
Colorectal cancer (CRC) progression is shaped by the tumor microenvironment, particularly tumor-associated macrophages (TAMs), which often adopt immunosuppressive functions. CD300e, a myeloid receptor involved in immune regulation, has an …
View article: Textbook Outcome in Colorectal Surgery for Cancer: An Italian Version
Textbook Outcome in Colorectal Surgery for Cancer: An Italian Version Open
Background/Objectives: The textbook outcome (TO) is a composite tool introduced to uniform surgical units and regulate surgical quality and outcomes. A patient is considered TO only if all predetermined items are met. In colorectal surgery…
View article: Da Vinci single-port robotic system current application and future perspective in general surgery: A scoping review
Da Vinci single-port robotic system current application and future perspective in general surgery: A scoping review Open
Background The da Vinci Single-Port Robot System (DVSP) allows three robotic instruments and an articulated scope to be inserted through a single small incision. It received FDA approval in 2014 and was first introduced in 2018. The aim of…
View article: Trends in colorectal cancer surgical resection rates during the screening era: a retrospective study in Italy
Trends in colorectal cancer surgical resection rates during the screening era: a retrospective study in Italy Open
Background Faecal immunochemical test (FIT)-based screening is effective in reducing colorectal cancer (CRC) incidence, but its sensitivity for proximal lesions remains low. Objectives We compared age-adjusted CRC surgical resection rates …