Gayathri Samarasekera
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View article: Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells
Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells Open
Cell stress adaptation plays a key role in normal development and in various diseases including cancer. Caspases are activated in response to cell stress, and growing evidence supports their function in non-apoptotic cellular processes. A …
View article: Puncta intended: connecting the dots between autophagy and cell stress networks
Puncta intended: connecting the dots between autophagy and cell stress networks Open
Proteome profiling and global protein-interaction approaches have significantly improved our knowledge of the protein interactomes of autophagy and other cellular stress-response pathways. New discoveries regarding protein complexes, inter…
View article: Selection of the sex‐linked <i>inhibitor of apoptosis</i> in mountain pine beetle (<i>Dendroctonus ponderosae</i>) driven by enhanced expression during early overwintering
Selection of the sex‐linked <i>inhibitor of apoptosis</i> in mountain pine beetle (<i>Dendroctonus ponderosae</i>) driven by enhanced expression during early overwintering Open
The mountain pine beetle ( Dendroctonus ponderosae ) is an insect native to western North America; however, its geographical range has recently expanded north in BC and east into Alberta. To understand the population structure in the areas…
View article: C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src
C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src Open
The tricellular junction (TCJ) forms at the convergence of three neighboring epithelia. The targeting of Gliotactin, an essential TCJ protein, to the TCJ is controlled by phosphorylation and endocytosis. C-terminal Src kinase controls endo…
View article: Kinase control of the tricellular junction protein Gliotactin, and Gliotactin-induced phenotypes in epithelia
Kinase control of the tricellular junction protein Gliotactin, and Gliotactin-induced phenotypes in epithelia Open
This thesis investigates the kinase-mediated regulation of the tricellular junction protein, Gliotactin and signaling pathways involved in Gliotactin overexpression-induced detrimental phenotypes. Tricellular junctions (TCJ) are uniquely p…
View article: Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex
Magi Is Associated with the Par Complex and Functions Antagonistically with Bazooka to Regulate the Apical Polarity Complex Open
The mammalian MAGI proteins play important roles in the maintenance of adherens and tight junctions. The MAGI family of proteins contains modular domains such as WW and PDZ domains necessary for scaffolding of membrane receptors and intrac…
View article: The <i>Drosophila</i> tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184
The <i>Drosophila</i> tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184 Open
Epithelial bicellular and tricellular junctions are essential for establishing and maintaining permeability barriers. Tricellular junctions are formed by the convergence of three bicellular junctions at the corners of neighbouring epitheli…