Feng Ge
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View article: Determination of Multiple Metal Elements in Cyanobacteria Culture Media by Metal Capture/Enrichment Hyphenated with Inductively Coupled Plasma Mass Spectrometry
Determination of Multiple Metal Elements in Cyanobacteria Culture Media by Metal Capture/Enrichment Hyphenated with Inductively Coupled Plasma Mass Spectrometry Open
To address the challenges posed by extensive sample pretreatment and significant matrix interference in conventional metal quantification methods for cyanobacterial culture media, an automated online metal capture and enrichment system was…
View article: Mechanistic Study of Surface Nanocrystallization for Surface Modification in High-Strength Low-Alloy Steel
Mechanistic Study of Surface Nanocrystallization for Surface Modification in High-Strength Low-Alloy Steel Open
This study systematically investigates the surface nanocrystallization of 35CrMo steel induced by Ultrasonic Surface Rolling Processing (USRP). It reveals the formation of a gradient nanostructure, where martensite lath fragmentation under…
View article: AP2/ERF Transcription Factors Regulate the Biosynthesis of Terpenoids, Phenolics, and Alkaloids in Plants
AP2/ERF Transcription Factors Regulate the Biosynthesis of Terpenoids, Phenolics, and Alkaloids in Plants Open
AP2/ERF transcription factors (TFs) constitute a large, plant-specific family that acts as a central hub integrating developmental and environmental signals to modulate the biosynthesis of secondary metabolites. These compounds, including …
View article: Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymena thermophila
Proteogenomic Reassessment Provides Novel Insight into the Life Cycle of Tetrahymena thermophila Open
Tetrahymena thermophila (T. thermophila), a well-established model organism, has been instrumental in advancing our understanding of evolutionarily conserved biological processes. A key biological feature of this unicellular eukaryote is i…
View article: Chloroplast budding mediates β-carotene transport for early stage astaxanthin hyperaccumulation in microalgae
Chloroplast budding mediates β-carotene transport for early stage astaxanthin hyperaccumulation in microalgae Open
β-Carotene, the precursor of the high-value carotenoid astaxanthin, is transported into the cytoplasm via chloroplast membrane budding.
View article: Mechanistic Study of Surface Nanocrystallization for Surface Modification in High-Strength Low-Alloy Steel
Mechanistic Study of Surface Nanocrystallization for Surface Modification in High-Strength Low-Alloy Steel Open
This study systematically investigates the surface nanocrystallization mechanism of 35CrMo high-strength low-alloy (HSLA) steel induced by ultrasonic surface rolling processing (USRP), with particular emphasis on elucidating its optimizati…
View article: Effects of Rare Saponin Combinations of <i>Panax notoginseng</i> on Immune Function in Immunocompromised Mice
Effects of Rare Saponin Combinations of <i>Panax notoginseng</i> on Immune Function in Immunocompromised Mice Open
Objective: To examine the impact of Panax notoginseng rare saponin combinations on immune function in immunocompromised mice. Methods: Cyclophosphamide-induced immunodeficient mice were administered with unique combinations of saponins der…
View article: Small RNA ASpks2 Promote Mycobacterium tuberculosis Survival in Macrophages via Targeting Polyketide Synthase 2
Small RNA ASpks2 Promote Mycobacterium tuberculosis Survival in Macrophages via Targeting Polyketide Synthase 2 Open
Mycobacterium tuberculosis is the causative pathogen of human tuberculosis and a leading cause of death worldwide attributed to a single infectious agent. While small non-coding RNAs (sRNAs) have emerged as key regulators of bacterial path…
View article: PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1
PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1 Open
Cells need to reprogram their metabolism to adapt to extracellular nutrient changes. The yeast histone acetyltransferase SAGA (Spt-Ada-Gcn5-acetyltransferase) has been reported to acetylate its subunit Ada3 and form homo-dimers to enhance …
View article: Toxic Effects of Bis(4-hydroxyphenyl) Methane (BPF) on the Development and Reproduction of Chironomus tentans
Toxic Effects of Bis(4-hydroxyphenyl) Methane (BPF) on the Development and Reproduction of Chironomus tentans Open
Bis(4-hydroxyphenyl) methane (BPF), as a bisphenolic compound, has toxic effects on organisms such as endocrine disruption and immobilization of growth and development. This study evaluated the effect concentrations of BPF on Chironomus te…
View article: Lysine acetylation in cyanobacteria: emerging mechanisms and functions
Lysine acetylation in cyanobacteria: emerging mechanisms and functions Open
Cyanobacteria are ancient and abundant photosynthetic prokaryotes that play crucial roles in global carbon and nitrogen cycles. They exist in a variety of environments and have been used extensively as model organisms for studies of photos…
View article: Subphenotypic features of patients with sepsis and ARDS: a multicenter cohort study
Subphenotypic features of patients with sepsis and ARDS: a multicenter cohort study Open
Objectives Patients with sepsis are often comorbid with acute respiratory distress syndrome (ARDS), and the phenotypic characteristics of pulmonary and non-pulmonary infections leading to ARDS are still unclear. This study aimed to compare…
View article: Automated pretreatment of environmental water samples and non-targeted intelligent screening of organic compounds based on machine experiments
Automated pretreatment of environmental water samples and non-targeted intelligent screening of organic compounds based on machine experiments Open
The complexity of environmental pollutants poses significant challenges for monitoring and analysis, especially with the emergence of numerous emerging contaminants. Traditional analysis methods rely mainly on laboratory analysis, which in…
View article: Quantum Supersymmetries (II): Loewy Filtrations and Quantum de Rham Cohomology over Quantum Grassmann Superalgebra
Quantum Supersymmetries (II): Loewy Filtrations and Quantum de Rham Cohomology over Quantum Grassmann Superalgebra Open
We explore the indecomposable submodule structure of quantum Grassmann super-algebra $Ω_q(m|n)$ and its truncated objects $Ω_q(m|n,\textbf{r})$ in the case when $q=\varepsilon$ is an $\ell$-th root of unity. A net-like weave-lifting method…
View article: Intrathecal Drug Delivery System in Prepontine Cistern for Patients with Intractable Craniofacial Cancer Pain: A Multicenter Retrospective Study
Intrathecal Drug Delivery System in Prepontine Cistern for Patients with Intractable Craniofacial Cancer Pain: A Multicenter Retrospective Study Open
BACKGROUND: Patients with craniofacial cancer frequently suffer from severe pain. The traditional intrathecal, oral, or intravenous analgesics could only provide insufficient pain relief with many side effects. Thus, a more effective analg…
View article: Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular Carcinoma Progression and Serves as a Neutrophil-Related Prognostic Biomarker
Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular Carcinoma Progression and Serves as a Neutrophil-Related Prognostic Biomarker Open
Adhesion G protein-coupled receptor G2 (ADGRG2) is an orphan adhesion G protein-coupled receptor (GPCR), which performs a tumor-promoting role in certain cancers; however, it has not been systematically investigated in hepatocellular carci…
View article: Effects of Varying Planting Patterns on Wheat Aphids’ Occurrence and the Control Effect of Pesticide Reduction Spraying Process by Unmanned Aerial Vehicle
Effects of Varying Planting Patterns on Wheat Aphids’ Occurrence and the Control Effect of Pesticide Reduction Spraying Process by Unmanned Aerial Vehicle Open
A walnut–wheat intercropping pattern is practiced widely in southern Xinjiang to alleviate the contradiction between the lack of cultivated land resources and to increase economic value. Previous studies have confirmed that an alley croppi…
View article: Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/C <sup>Cdh1</sup> complex
Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/C <sup>Cdh1</sup> complex Open
H3K4 trimethylation (H3K4me3) is a conserved histone modification catalyzed by histone methyltransferase Set1, and its dysregulation is associated with pathologies. Here, we show that Set1 is intrinsically unstable and elucidate how its pr…
View article: Deciphering the structure, function, and mechanism of lysine acetyltransferase cGNAT2 in cyanobacteria
Deciphering the structure, function, and mechanism of lysine acetyltransferase cGNAT2 in cyanobacteria Open
Lysine acetylation is a conserved regulatory posttranslational protein modification that is performed by lysine acetyltransferases (KATs). By catalyzing the transfer of acetyl groups to substrate proteins, KATs play critical regulatory rol…
View article: PP2C phosphatases Ptc1 and Ptc2 dephosphorylate PGK1 to regulate autophagy and aflatoxin synthesis in the pathogenic fungus <i>Aspergillus flavus</i>
PP2C phosphatases Ptc1 and Ptc2 dephosphorylate PGK1 to regulate autophagy and aflatoxin synthesis in the pathogenic fungus <i>Aspergillus flavus</i> Open
Reversible phosphorylation by protein kinases and phosphatases plays a central role in regulating cellular processes. However, knowledge of the functions of protein phosphatase 2C (PP2C) S/T phosphatases in Aspergillus flavus has been unre…
View article: Effects on the yield and fiber quality components of <i>Bt</i> cotton inoculated with <i>Azotobacter chroococcum</i> under elevated CO<sub>2</sub>
Effects on the yield and fiber quality components of <i>Bt</i> cotton inoculated with <i>Azotobacter chroococcum</i> under elevated CO<sub>2</sub> Open
Background The raising trend of cultivation of Bacillus thuringiensis ( Bt )-transgenic cotton is faced with a new challenge what effects on the growth and yield of Bt cotton under elevated CO 2 . Methods Rhizobacteria is the significant b…
View article: Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway
Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway Open
Normally, during viral infection, host antiviral factors individually modulate the host immune response or antagonize viral components to defense infection. In the present study, we report that zebrafish MAP2K7 plays a crucial positive rol…
View article: FERMT1 Is a Prognostic Marker Involved in Immune Infiltration of Pancreatic Adenocarcinoma Correlating with m6A Modification and Necroptosis
FERMT1 Is a Prognostic Marker Involved in Immune Infiltration of Pancreatic Adenocarcinoma Correlating with m6A Modification and Necroptosis Open
As an important member of the kindlin family, fermitin family member 1 (FERMT1) can interact with integrin and its aberrant expression involves multiple tumors. However, there are few systematic studies on FERMT1 in pancreatic carcinoma (P…
View article: The AMP-Activated Protein Kinase (AMPK) Positively Regulates Lysine Biosynthesis Induced by Citric Acid in Flammulina filiformis
The AMP-Activated Protein Kinase (AMPK) Positively Regulates Lysine Biosynthesis Induced by Citric Acid in Flammulina filiformis Open
Flammulina filiformis, the most produced edible mushroom species in China, is rich in lysine. Further enhancing its lysine biosynthesis is vital for improving its quality in industrialized cultivation. Citric acid induction significantly i…
View article: Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence Open
Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular diseases in ageing population. Although ECs rely on glycolysis for energy production, little is known about the role of glycolysis in ECs senescence…
View article: The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy
The TORC1 activates Rpd3L complex to deacetylate Ino80 and H2A.Z and repress autophagy Open
Autophagy is a critical process to maintain homeostasis, differentiation, and development. How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we identify chromatin remodeling protein Ino80 and histone var…
View article: cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria
cKMT1 is a New Lysine Methyltransferase That Methylates the Ferredoxin-NADP(+) Oxidoreductase and Regulates Energy Transfer in Cyanobacteria Open
Lysine methylation is a conserved and dynamic regulatory posttranslational modification performed by lysine meth-yltransferases (KMTs). KMTs catalyze the transfer of mono-, di-, or tri-methyl groups to substrate proteins and play a critica…