Kai Ge
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View article: Optimizing GC-IMS for Pork Volatile Fingerprinting: Effects of Incubation Conditions and Medium on Aroma Profiles
Optimizing GC-IMS for Pork Volatile Fingerprinting: Effects of Incubation Conditions and Medium on Aroma Profiles Open
Volatile organic compounds (VOCs) are key aroma determinants in pork, and gas chromatography-ion mobility spectrometry (GC-IMS) is an effective technique for their detection. However, the detection conditions for pork using GC-IMS have yet…
View article: Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism
Enhancer regulator MLL4 controls skeletal muscle metabolic efficiency by limiting AMPK-mediated fuel catabolism Open
Skeletal muscle is a major organ for maintaining whole-body energy balance, yet how it adapts its transcriptional and metabolic programs to environmental cues remains unclear. Here, we report that histone mono-methyltransferase mixed linea…
View article: Research on the differences in the spatial distribution of land resource security in North China based on the DPSIRM model
Research on the differences in the spatial distribution of land resource security in North China based on the DPSIRM model Open
Land ecological safety has become a key issue in the pursuit of ethical and sustainable land use. This study, based on the DPSIRM (Driving force–Pressure–State–Impact–Response–Management) framework, employed the entropy weight TOPSIS model…
View article: Water-soluble polysaccharides derived from Poria cocos protect against LPS-induced renal injury through inhibiting the NF-κB-NOX4 signaling pathway
Water-soluble polysaccharides derived from Poria cocos protect against LPS-induced renal injury through inhibiting the NF-κB-NOX4 signaling pathway Open
Sepsis frequently results in acute kidney injury (AKI), characterized by oxidative damage and inflammation. Polysaccharides derived from Poria cocos have significant anti-inflammatory and antioxidant effects. This study aims to investigate…
View article: Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism
Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism Open
Chronic hyperglycemia, a defining feature of type 2 diabetes (T2D) and related metabolic disorders, exacerbates insulin resistance and impairs muscle glucose utilization, contributing to systemic metabolic dysfunction. While skeletal muscl…
View article: Insights into infraspecific differentiation of the medicinally important species Bupleurum Chinense revealed by morphological and molecular evidence
Insights into infraspecific differentiation of the medicinally important species Bupleurum Chinense revealed by morphological and molecular evidence Open
Distinct infraspecific variation was revealed through integrated morphological and molecular data. Morphological clustering analysis identified two geographically associated clusters, roughly corresponding to coastal and inland regions. Al…
View article: Observed seasonal evolution and origins of the western Yellow Sea Cold Water Mass
Observed seasonal evolution and origins of the western Yellow Sea Cold Water Mass Open
The Yellow Sea Cold Water Mass (YSCWM) is one of the most prominent hydrological features of the Yellow Sea. As a low-temperature, nutrient-rich subsurface water mass, the YSCWM fundamentally regulates biogeochemical cycles, functions of m…
View article: Histone chaperone HIRA facilitates transcription elongation to regulate insulin sensitivity and obesity-associated adipose expansion
Histone chaperone HIRA facilitates transcription elongation to regulate insulin sensitivity and obesity-associated adipose expansion Open
Adipose tissue is essential for maintaining glucose and lipid homeostasis in mammals. The histone chaperone HIRA has been reported to play a lineage- and stage-selective role during development. However, its role in adipose tissue developm…
View article: Proteomics analysis revealed the mechanism of differential egg productive in geese
Proteomics analysis revealed the mechanism of differential egg productive in geese Open
Background The Western Anhui white goose is a highly esteemed breed in our country, renowned for its superior meat quality and exceptional egg-laying performance. As the primary reproductive organ in poultry, the ovary significantly influe…
View article: <i>Smad8</i> is involvement in follicular development via the regulation of granulosa cell growth and steroidogenesis in mice
<i>Smad8</i> is involvement in follicular development via the regulation of granulosa cell growth and steroidogenesis in mice Open
Background: SMAD family proteins (SMADs) are crucial transcription factors downstream of transforming growth factor beta (TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian reproduction.However, the …
View article: BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation
BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation Open
Cornelia de Lange syndrome (CdLS) is a congenital disorder featuring facial dysmorphism, postnatal growth deficits, cognitive disability and upper limb abnormalities. CdLS is genetically heterogeneous, with cases arising from mutation of B…
View article: H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis
H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis Open
Osteoarthritis (OA) is the most common joint diseases, there are no disease-modifying drugs, and the pathological mechanisms of OA need further study. Here, we show that H3K36 methylations were decreased in senescent chondrocytes and age-i…
View article: <scp>KMT2D</scp> links <scp>TGF</scp> ‐β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity
<span>KMT2D</span> links <span>TGF</span> ‐β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity Open
Although KMT2D, also known as MLL2, is known to play an essential role in development, differentiation, and tumor suppression, its role in pancreatic cancer development is not well understood. Here, we discovered a novel signaling axis med…
View article: Data from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i>
Data from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i> Open
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an undifferentiated status and generally poor prognosis, but the basis for these characteristics remains unknown. In this study, we show that upregulation of the…
View article: Supplementary Tables 1-3 from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i>
Supplementary Tables 1-3 from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i> Open
PDF file - 93K
View article: Supplementary Tables 1-3 from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i>
Supplementary Tables 1-3 from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i> Open
PDF file - 93K
View article: Data from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i>
Data from EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes <i>CASZ1</i>, <i>CLU</i>, <i>RUNX3</i>, and <i>NGFR</i> Open
Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with an undifferentiated status and generally poor prognosis, but the basis for these characteristics remains unknown. In this study, we show that upregulation of the…