Yali Ge
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Author Swipe
View article: Associations of accelerated biological aging with intraoperative hypotension in major surgery: a multicenter cohort study of 116,996 patients
Associations of accelerated biological aging with intraoperative hypotension in major surgery: a multicenter cohort study of 116,996 patients Open
Accelerated biological aging was significantly associated with both increased risk and greater severity of intraoperative hypotension. These findings support the integration of biological aging metrics, such as PhenoAgeAccel, into preopera…
View article: Machine-learning approach uncovers hemodynamic-driven phenotypes in cardiac surgery by clustering multimodal, high-dimensional perioperative data
Machine-learning approach uncovers hemodynamic-driven phenotypes in cardiac surgery by clustering multimodal, high-dimensional perioperative data Open
Background: A critical limitation of current risk assessment in cardiac surgery is its reliance on static preoperative models, which fail to account for dynamic intraoperative physiological changes. This limitation may lead to the oversigh…
View article: Effects of combining epidural with general anesthesia on postoperative sleep and pain in elderly patients undergoing gastrointestinal tumor surgery: a prospective randomized trial
Effects of combining epidural with general anesthesia on postoperative sleep and pain in elderly patients undergoing gastrointestinal tumor surgery: a prospective randomized trial Open
The study was registered at Chinese Clinical Trial Registry http//www.chictr.org.cn/ (Registration date 04/04/2021 Trial ID ChiCTR2100045064).
View article: Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders
Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders Open
Perioperative neurocognitive disorders (PND), including postoperative delirium, preoperatively cognitive impairment, postoperative cognitive dysfunction, and delayed neurocognitive recovery, represent common complications following anesthe…
View article: Drive Pressure-Guided Individualized Positive End-Expiratory Pressure in Traumatic Brain Injury Surgery: A Randomized Controlled Trial
Drive Pressure-Guided Individualized Positive End-Expiratory Pressure in Traumatic Brain Injury Surgery: A Randomized Controlled Trial Open
AIM: Intraoperative lung-protective ventilation strategies (LPVS) have been shown to improve lung oxygenation and prevent postoperative pulmonary problems in surgical patients. However, the application of positive end-expiratory pressure (…
View article: Effects of intraoperative open-lung strategy on cardiopulmonary function in frail elderly patients undergoing laparoscopic surgery: a randomized controlled trial
Effects of intraoperative open-lung strategy on cardiopulmonary function in frail elderly patients undergoing laparoscopic surgery: a randomized controlled trial Open
Purpose This study aimed to investigate the potential effects of intraoperative open-lung strategy (OLS) on pulmonary function and cardiac function in elderly frail patients. Methods 104 frail elderly patients were randomly assigned into n…
View article: Association of hospital teaching characteristics with readmission and complication outcomes among patients receiving radiotherapy and brachytherapy for breast cancer: A Nationwide Readmissions Database Analysis
Association of hospital teaching characteristics with readmission and complication outcomes among patients receiving radiotherapy and brachytherapy for breast cancer: A Nationwide Readmissions Database Analysis Open
Background Radiotherapy and brachytherapy are common treatments for breast cancer, but few studies have examined the impact of hospital characteristics on patient outcomes. This study evaluated the influence of hospital teaching status on …
View article: Decoding neuronal genes in stroke-induced pain: insights from single-nucleus sequencing in mice
Decoding neuronal genes in stroke-induced pain: insights from single-nucleus sequencing in mice Open
This study identified the role of key genes in thalamic hemorrhage-induced CPSP through snRNA-seq, providing a scientific basis for further exploration of the molecular mechanisms underlying CPSP.
View article: The Cytidine N-Acetyltransferase NAT10 Promotes Thalamus Hemorrhage-Induced Central Poststroke Pain by Stabilizing Fn14 Expression in Thalamic Neurons
The Cytidine N-Acetyltransferase NAT10 Promotes Thalamus Hemorrhage-Induced Central Poststroke Pain by Stabilizing Fn14 Expression in Thalamic Neurons Open
The recognition of RNA N4-acetylcytidine (ac4C) modification as a significant type of gene regulation is growing; nevertheless, whether ac4C modification or the N-acetyltransferase 10 protein (NAT10, the only ac4C “writer” that is presentl…
View article: Risk factors for postoperative delirium in frail elderly patients undergoing on-pump cardiac surgery and development of a prediction model—a prospective observational study
Risk factors for postoperative delirium in frail elderly patients undergoing on-pump cardiac surgery and development of a prediction model—a prospective observational study Open
Background To identify the risk factors for postoperative delirium (POD) after cardiac surgery in frail elderly patients and develop a receiver operating characteristic (ROC) prediction model to confirm the effectiveness. Methods This was …
View article: Microwave hydrothermal synthesis and characterization of aluminum substituted tobermorite
Microwave hydrothermal synthesis and characterization of aluminum substituted tobermorite Open
In tackling the sustainability challenges encountered in conventional hydrothermal synthesis, the microwave hydrothermal synthesis emerges as a promising approach, offering various advantages such as accelerated heating and energy efficien…
View article: Genetically supported causality between gut microbiota, immune cells, and ischemic stroke: a two-sample Mendelian randomization study
Genetically supported causality between gut microbiota, immune cells, and ischemic stroke: a two-sample Mendelian randomization study Open
Background Previous studies have highlighted a robust correlation between gut microbiota/immune cells and ischemic stroke (IS). However, the precise nature of their causal relationship remains uncertain. To address this gap, our study aims…
View article: Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study
Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study Open
Background A mounting body of evidence suggests a strong connection between gut microbiota and the risk of frailty. However, the question of causality remains unanswered. In this study, we employed a Mendelian randomization (MR) approach t…
View article: Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways
Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways Open
Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients, families, and society. Currently, treatment outcomes for this disease are often unsatisfactor…
View article: Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study
Genetically supported causality between gut microbiota, immune cells and morphine tolerance: a two-sample Mendelian randomization study Open
Background Previous researches have suggested a significant connection between the gut microbiota/immune cells and morphine tolerance (MT), but there is still uncertainty regarding their causal relationship. Hence, our objective is to inve…
View article: Piezo2 contributes to traumatic brain injury by activating the RhoA/ROCK1 pathways
Piezo2 contributes to traumatic brain injury by activating the RhoA/ROCK1 pathways Open
Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients, families, and society. Currently, treatment outcomes for this disease are often unsatisfactor…
View article: Effect of trans-nasal humidified rapid insufflation ventilatory exchange on reflux and microaspiration in patients undergoing laparoscopic cholecystectomy during induction of general anesthesia: a randomized controlled trial
Effect of trans-nasal humidified rapid insufflation ventilatory exchange on reflux and microaspiration in patients undergoing laparoscopic cholecystectomy during induction of general anesthesia: a randomized controlled trial Open
Background Reflux aspiration is a rare but serious complication during induction of anesthesia. The primary aim of this study is to compare the incidence of reflux and microaspiration in patients undergoing laparoscopic cholecystectomy dur…
View article: Ultrasound assessment of gastric content in patients undergoing laparoscopic cholecystectomy after preoperative oral carbohydrates: a prospective, randomized controlled, double-blind study
Ultrasound assessment of gastric content in patients undergoing laparoscopic cholecystectomy after preoperative oral carbohydrates: a prospective, randomized controlled, double-blind study Open
Background To evaluate the gastric volume and nature after drinking preoperative oral carbohydrates in patients undergoing laparoscopic cholecystectomy via ultrasonography. Methods One hundred patients who had been scheduled for elective l…
View article: Comparison of Carotid Blood Flow Measured by Ultrasound and Cardiac Output in Patients Undergoing Cardiac Surgery
Comparison of Carotid Blood Flow Measured by Ultrasound and Cardiac Output in Patients Undergoing Cardiac Surgery Open
Background: In general, cerebral blood flow accounts for 10–15% of cardiac output (CO), of which about 75% is delivered through the carotid arteries. Hence, if carotid blood flow (CBF) is constantly proportional to CO with high reproducibi…
View article: Apoptotic mechanism of propofol-induced developmental toxicity in zebrafish embryos
Apoptotic mechanism of propofol-induced developmental toxicity in zebrafish embryos Open
General anesthetics can cause neurological damage and long-term behavioral/cognitive impairment during fetal and early postnatal life. However, the adverse influence on embryo development induced by propofol is unclear. We used embryonic z…
View article: When ankylosing spondylitis coincides with spontaneous cervical fracture: A case report
When ankylosing spondylitis coincides with spontaneous cervical fracture: A case report Open
• Patients with severe ankylosing spondylitis require an adequate preoperative airway assessment. • Prolongation of safe apnea with adequate preoxygenation using transnasal high flow nasal cannula oxygen prior to induction of anesthesia. •…
View article: Combination of single-nucleus and bulk RNA-seq reveals the molecular mechanism of thalamus haemorrhage-induced central poststroke pain
Combination of single-nucleus and bulk RNA-seq reveals the molecular mechanism of thalamus haemorrhage-induced central poststroke pain Open
Central poststroke pain (CPSP) induced by thalamic haemorrhage (TH) can be continuous or intermittent and is accompanied by paresthesia, which seriously affects patient quality of life. Advanced insights into CPSP mechanisms and therapeuti…
View article: The use of multiple datasets to identify autophagy-related molecular mechanisms in intracerebral hemorrhage
The use of multiple datasets to identify autophagy-related molecular mechanisms in intracerebral hemorrhage Open
Background: Intracerebral hemorrhage (ICH) is a stroke syndrome with high mortality and disability rates, but autophagy’s mechanism in ICH is still unclear. We identified key autophagy genes in ICH by bioinformatics methods and explored th…
View article: Ultrasound assessment of gastric content in patients undergoing laparoscopic cholecystectomy after preoperative oral carbohydrates: A prospective, randomized controlled, double-blind study
Ultrasound assessment of gastric content in patients undergoing laparoscopic cholecystectomy after preoperative oral carbohydrates: A prospective, randomized controlled, double-blind study Open
Background: Cholelithiasis patients present with delayed stomach emptying due to pathophysiological abnormalities in the gastrointestinal system. We analyzed the gastric volume and nature after drinking preoperative oral carbohydrates in p…
View article: Comparison of Carotid Blood Flow measured by Ultrasound and cardiac output in Patients undergoing Cardiac Surgery
Comparison of Carotid Blood Flow measured by Ultrasound and cardiac output in Patients undergoing Cardiac Surgery Open
In general, cerebral blood flow accounts for 10–15% of cardiac output (CO), of which about 75% was delivered through the carotid arteries. Hence, if carotid blood flow (CBF) is constantly proportional to CO with high reproducibility and re…
View article: miR‑223 ameliorates thalamus hemorrhage‑induced central poststroke pain via targeting NLRP3 in a mouse model
miR‑223 ameliorates thalamus hemorrhage‑induced central poststroke pain via targeting NLRP3 in a mouse model Open
Central poststroke pain (CPSP) is a central neuropathic pain syndrome that occurs following a stroke and mainly manifests as pain and paresthesia in the body region corresponding to the brain injury area. At present, due to the lack of cli…