Gechang Yu
YOU?
Author Swipe
View article: Author Correction: Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence
Author Correction: Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence Open
View article: A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population
A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population Open
Aims/hypothesis We aimed to generate a population-specific type 1 diabetes genetic risk score (GRS) and assess whether it could improve discrimination between type 1 diabetes and type 2 diabetes in a Chinese population. Methods We performe…
View article: Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence
Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence Open
View article: A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular–kidney complications
A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular–kidney complications Open
Aims/hypothesis Monogenic diabetes is caused by rare mutations in genes usually implicated in beta cell biology. Common variants of monogenic diabetes genes (MDG) may jointly influence the risk of young-onset type 2 diabetes (YOD, diagnose…
View article: Type 2 diabetes pathway-specific polygenic risk scores elucidate heterogeneity in clinical presentation, disease progression and diabetic complications in 18,217 Chinese individuals with type 2 diabetes
Type 2 diabetes pathway-specific polygenic risk scores elucidate heterogeneity in clinical presentation, disease progression and diabetic complications in 18,217 Chinese individuals with type 2 diabetes Open
View article: The suicidal youth: psychopathological subtypes with genetic, neuroanatomical and environmental differences
The suicidal youth: psychopathological subtypes with genetic, neuroanatomical and environmental differences Open
Youth suicidality is characterized by its transient nature and diverse causal pathways. Currently, a unified approach searching for final common pathway towards youth suicide has proven unsuccessful. Therefore an exploration of its heterog…
View article: Pre-adolescent Brain Asymmetry: Developmental Trajectory, Cognitive and Psychiatric Effects, Neurobiological and Environmental Influences in ABCD Study
Pre-adolescent Brain Asymmetry: Developmental Trajectory, Cognitive and Psychiatric Effects, Neurobiological and Environmental Influences in ABCD Study Open
Cerebral asymmetry is fundamental to various cognitive functions but is often disrupted in neuropsychiatric disorders. While adolescent brain growth has been extensively studied, the maturation of brain asymmetry in children and its influe…
View article: Identifying subtypes of youth suicidality based on psychopathology: alterations in genetic, neuroanatomical and environmental features
Identifying subtypes of youth suicidality based on psychopathology: alterations in genetic, neuroanatomical and environmental features Open
Summary One of the most complex human behaviours that defies singular explanatory models is suicidal behaviour, especially in the youth. A promising approach to make progress with this conundrum is to parse distinct subtypes of this behavi…
View article: Lessons and Applications of Omics Research in Diabetes Epidemiology
Lessons and Applications of Omics Research in Diabetes Epidemiology Open
Purpose of Review Recent advances in genomic technology and molecular techniques have greatly facilitated the identification of disease biomarkers, advanced understanding of pathogenesis of different common diseases, and heralded the dawn …
View article: Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis
Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis Open
View article: Dose-Response Relationships between Physical Exercises and Mental Health during Early Adolescence: an Investigation of the Underlying Neural and Genetic Mechanisms from the ABCD Study
Dose-Response Relationships between Physical Exercises and Mental Health during Early Adolescence: an Investigation of the Underlying Neural and Genetic Mechanisms from the ABCD Study Open
Adolescence is a critical developmental with increased vulnerability to mental disorders. While the positive impact of physical exercise on adult mental health is well-established, dose-response relationships and the underlying neural and …
View article: Decoding anxiety–impulsivity subtypes in preadolescent internalising disorders: findings from the Adolescent Brain Cognitive Development study
Decoding anxiety–impulsivity subtypes in preadolescent internalising disorders: findings from the Adolescent Brain Cognitive Development study Open
Background Internalising disorders are highly prevalent emotional dysregulations during preadolescence but clinical decision-making is hampered by high heterogeneity. During this period impulsivity represents a major risk factor for psycho…
View article: Common and disorder-specific cortical thickness alterations in internalizing, externalizing and thought disorders during early adolescence: an Adolescent Brain and Cognitive Development study
Common and disorder-specific cortical thickness alterations in internalizing, externalizing and thought disorders during early adolescence: an Adolescent Brain and Cognitive Development study Open
Background: A growing body of neuroimaging studies has reported common neural abnormalities among mental disorders in adults. However, it is unclear whether the distinct disorder-specific mechanisms operate during adolescence despite the o…
View article: Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study
Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study Open
Background Comorbidity is the rule rather than the exception for childhood and adolescent onset mental disorders, but we cannot predict its occurrence and do not know the neural mechanisms underlying comorbidity. We investigate if the effe…
View article: Precision Prognostics for Cardiovascular Disease in Type 2 Diabetes: A Systematic Review and Meta-analysis
Precision Prognostics for Cardiovascular Disease in Type 2 Diabetes: A Systematic Review and Meta-analysis Open
Background: Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with type 2 diabetes (T2D). Methods: We conducted a systematic review and meta-analysis of longitudinal studies to iden…
View article: Precision Prognostics for Cardiovascular Disease in Type 2 Diabetes: A Systematic Review and Meta-analysis
Precision Prognostics for Cardiovascular Disease in Type 2 Diabetes: A Systematic Review and Meta-analysis Open
Background Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with type 2 diabetes (T2D). Methods We conducted a systematic review and meta-analysis of longitudinal studies to identi…
View article: Additional file 2 of Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study
Additional file 2 of Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study Open
Additional file 2: Table S1. Demographics of the three transdiagnostic categories and healthy control. Table S2. Frequency of each single mental disorders within each group. Table S3. FUMA summary for main significant loci for cortical thi…
View article: Specificity of cortical area and thickness as biomarkers for comorbid internalizing and externalizing mental disorders in pre-adolescence
Specificity of cortical area and thickness as biomarkers for comorbid internalizing and externalizing mental disorders in pre-adolescence Open
Background Comorbidity is the rule rather than the exception for childhood and adolescent onset mental disorders, but we cannot predict its occurrence and do not know the neural mechanisms underlying comorbidity. We investigate if the effe…
View article: Anxiety-impulsivity subtypes in adolescent internalizing disorder are characterized by distinguishable neurodevelopmental, neurocognitive and clinical trajectory signatures
Anxiety-impulsivity subtypes in adolescent internalizing disorder are characterized by distinguishable neurodevelopmental, neurocognitive and clinical trajectory signatures Open
Background Anxiety and impulsivity represent transdiagnostic pathology dimensions yet their interaction and contribution to emotional disorders in adolescence and to disease development remain controversial, and previous studies indicate h…
View article: Common and Disorders-Specific Cortical Thickness Alterations in Internalizing, Externalizing and Thought Disorders over a 2-year Period in the Preadolescents of the ABCD Study
Common and Disorders-Specific Cortical Thickness Alterations in Internalizing, Externalizing and Thought Disorders over a 2-year Period in the Preadolescents of the ABCD Study Open
Overlap of brain changes across mental disorders has reinforced transdiagnostic models. However, the developmental basis for this overlap is unclear as are neural differences among internalizing, externalizing and thought disorders. These …