Geehan Suleyman
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View article: Genomic Surveillance for SARS-CoV-2 During the COVID-19 Pandemic: Collaborative Experience at Southeast Michigan
Genomic Surveillance for SARS-CoV-2 During the COVID-19 Pandemic: Collaborative Experience at Southeast Michigan Open
Regional genomic surveillance is essential for tracking viral evolution and informing targeted public health responses. During the COVID-19 pandemic, we established a collaborative genomic surveillance pipeline for SARS-CoV-2 in Southeast …
View article: Whole-genome analysis of extensively drug-resistant <i>Enterobacter hormaechei</i> isolated from two hospitalized patients in the United States: A case series of a rare but rising threat
Whole-genome analysis of extensively drug-resistant <i>Enterobacter hormaechei</i> isolated from two hospitalized patients in the United States: A case series of a rare but rising threat Open
Background New Delhi metallo-beta-lactamases (NDM) confer extensive antibiotic resistance, complicating treatment and leading to poor outcomes. In 2022, two patients at a US academic medical centre in Southeast Michigan were infected with …
View article: Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novel OptrA variant and regional emergence of an ST9 lineage co-circulating with international CC398 lineages
Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novel OptrA variant and regional emergence of an ST9 lineage co-circulating with international CC398 lineages Open
Introduction Staphylococcus aureus (SA) colonizes both humans and animals. The spread of livestock-associated methicillin-resistant S. aureus (LA-MRSA) in farms and the environment poses a public health concern. While CC398 is globally pre…
View article: Genomic Analysis and Virulence Features of <i>Vibrio cholerae</i> Non‐ <scp>O1</scp> /Non‐ <scp>O139</scp> Harbouring <scp>CARB</scp> ‐Type β‐Lactamases From Freshwater Bodies, Argentina
Genomic Analysis and Virulence Features of <i>Vibrio cholerae</i> Non‐ <span>O1</span> /Non‐ <span>O139</span> Harbouring <span>CARB</span> ‐Type β‐Lactamases From Freshwater Bodies, Argentina Open
Vibrio cholerae is a globally distributed, free‐living bacterium in aquatic ecosystems. While non‐O1/non‐O139 serogroups typically do not produce cholera toxin, they have the potential to cause diarrhoea. These strains may act as reservoir…
View article: Clinical and Genomic Characterization of Recalcitrant Enterococcal Bacteremia: A Multicenter Prospective Cohort Study (VENOUS)
Clinical and Genomic Characterization of Recalcitrant Enterococcal Bacteremia: A Multicenter Prospective Cohort Study (VENOUS) Open
Background Patients with recalcitrant enterococcal bloodstream infections are at greater risk of adverse outcomes. We identified patients in the 2016-2022 Vancomycin-Resistant Enterococcal Bacteremia Outcomes Study (VENOUS) cohort experien…
View article: P-1707. A Comparative Analysis of Clindamycin versus Linezolid as Adjunctive Anti-toxin Therapy for Invasive Group A <i>Streptococcal</i> Infections
P-1707. A Comparative Analysis of Clindamycin versus Linezolid as Adjunctive Anti-toxin Therapy for Invasive Group A <i>Streptococcal</i> Infections Open
Background Group A Streptococcus (GAS) is an important pathogen that can cause life-threatening disease. Clindamycin (DA) and linezolid (LZD) have been used as adjunctive antitoxin (AT) therapy in high-inoculum GAS infections to inhibit ba…
View article: P-1538. Analyzing Trends and Outcomes of Clindamycin Resistant Invasive Group A Streptococci Infections
P-1538. Analyzing Trends and Outcomes of Clindamycin Resistant Invasive Group A Streptococci Infections Open
Background Streptococcus pyogenes (Group A Streptococci; GAS) is a gram-positive bacterium that is a leading cause of life-threatening infections. For invasive infections, IDSA recommends high-dose penicillin and clindamycin (DA). However,…
View article: P-1410. Oral Antimicrobial Therapy Offers in Hospitalized Persons Who Inject Drugs who Elect for Self-directed Discharge
P-1410. Oral Antimicrobial Therapy Offers in Hospitalized Persons Who Inject Drugs who Elect for Self-directed Discharge Open
Background Hospitalized Persons Who Inject Drugs (PWID) who elect for self-directed discharge (SDD) are at an increased risk for poor infection outcomes, but there is limited guidance for infection management in this population. National P…
View article: P-1843. Genomic surveillance of invasive <i>Streptococcus pyogenes</i> in Metropolitan Detroit
P-1843. Genomic surveillance of invasive <i>Streptococcus pyogenes</i> in Metropolitan Detroit Open
Background Group A streptococcal (GAS) disease is a major problem worldwide and can cause both noninvasive and invasive disease, including necrotizing fasciitis, with significant morbidity and mortality. Overall, the number of invasive GAS…
View article: P-821. Invasive Streptococcus pyogenes Infections: Is Anti-toxin Therapy Necessary?
P-821. Invasive Streptococcus pyogenes Infections: Is Anti-toxin Therapy Necessary? Open
Background Invasive Streptococcus pyogenes or group A Streptococcus (GAS) carries a high morbidity and mortality rate. In addition to penicillin, adjunct anti-toxin therapy (AT) with linezolid or clindamycin is the standard of care. Althou…
View article: 162. Comparison of Clinical Risk Factors, Outcomes and Molecular Epidemiology of ESBL and non-ESBL Enterobacterales Bacteremia in Solid Organ Transplant Recipients
162. Comparison of Clinical Risk Factors, Outcomes and Molecular Epidemiology of ESBL and non-ESBL Enterobacterales Bacteremia in Solid Organ Transplant Recipients Open
Background Infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales are associated with adverse outcomes in recipients of solid organ transplants (SOTr). This study aims to elucidate the risk factors, outcome…
View article: P-1814. Say it Ain't Steno - Impact of a Microbiology Nudge Comment on Treatment of Respiratory Colonization
P-1814. Say it Ain't Steno - Impact of a Microbiology Nudge Comment on Treatment of Respiratory Colonization Open
Background Stenotrophomonas maltophilia (SM) is a known colonizer of the respiratory tract, in which treatment is not required. Microbiological comment “nudges” have been successful as passive stewardship interventions. The study objective…
View article: P-380. Risk Factors and Clinical Outcomes of Breast Surgery Related Surgical Site Infections in Southeast Michigan
P-380. Risk Factors and Clinical Outcomes of Breast Surgery Related Surgical Site Infections in Southeast Michigan Open
Background Surgical site infections (SSI) after breast surgery are important healthcare-associated infections (HAI) that may delay initiation of chemotherapy for underlying malignancy, in addition to accruing substantial healthcare costs. …
View article: P-361. Outcome of Candida auris Point Prevalence Survey in a Tertiary Care Hospital in Southeast Michigan
P-361. Outcome of Candida auris Point Prevalence Survey in a Tertiary Care Hospital in Southeast Michigan Open
Background C. auris, an emerging multi-drug resistant organism associated with nosocomial outbreaks, is becoming more prevalent in Southeast Michigan due to interfacility healthcare transfer. The CDC recommends contact isolation and screen…
View article: P-389. Review of Post Cesarian Section Surgical Site Infections in a Tertiary Care Hospital
P-389. Review of Post Cesarian Section Surgical Site Infections in a Tertiary Care Hospital Open
Background Surgical site infection (SSI) is one of the most common complications following cesarean section (CSEC), variably ranging from 3% to 18%, and adds a significant burden to the healthcare system. Given its substantial implications…
View article: P-1765. Are we there yet? The ongoing journey for improving management of asymptomatic bacteriuria
P-1765. Are we there yet? The ongoing journey for improving management of asymptomatic bacteriuria Open
Background Treating asymptomatic bacteriuria (ASB) with antibiotics contributes to preventable patient harm. This quality improvement study aimed to evaluate the effectiveness of ongoing diagnostic and antibiotic stewardship interventions …
View article: P-1344. Molecular Characterization of Daptomycin Non-susceptible <i>Staphylococcus aureus</i>
P-1344. Molecular Characterization of Daptomycin Non-susceptible <i>Staphylococcus aureus</i> Open
Background Staphylococcus aureus (SA) is the leading cause of bacteremia in hospitalized patients. With limited therapeutic options, increasing use of daptomycin (DAP) has resulted in the emergence of DAP non-susceptible (DNS) SA strains. …
View article: P-767. Unveiling Tuberculosis: A Perspective on Active vs. Subclinical Pulmonary Tuberculosis
P-767. Unveiling Tuberculosis: A Perspective on Active vs. Subclinical Pulmonary Tuberculosis Open
Background Despite being preventable and curable, tuberculosis (TB) remains one of the world’s leading infectious disease killers with 1.5 million people dying each year worldwide. The U.S. has one of the world’s lowest rates of TB; howeve…
View article: A little nudge goes a long way: assessing the impact of a microbiology nudge comment on narrow-spectrum antibiotic use in uncomplicated <i>Streptococcus pneumoniae</i> bloodstream infections
A little nudge goes a long way: assessing the impact of a microbiology nudge comment on narrow-spectrum antibiotic use in uncomplicated <i>Streptococcus pneumoniae</i> bloodstream infections Open
Narrow-spectrum antibiotic prescribing (ampicillin IV or penicillin IV) was compared before and after implementing an interpretive microbiology comment for uncomplicated Streptococcus pneumoniae bloodstream infections. The postintervention…
View article: Say it ain’t <i>Steno</i>: a microbiology nudge comment leads to less treatment of <i>Stenotrophomonas maltophilia</i> respiratory colonization
Say it ain’t <i>Steno</i>: a microbiology nudge comment leads to less treatment of <i>Stenotrophomonas maltophilia</i> respiratory colonization Open
Objective: To describe the effect of a Stenotrophomonas maltophilia (SM) respiratory culture nudge on antibiotic use in colonized patients. Design: IRB-approved quasi-experiment. Setting: Five acute-care hospitals in Michigan. Patients: Ad…
View article: Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series
Characterisation, management, and outcomes of New Delhi metallo-β-lactamase-producing Escherichia coli: A case series Open
This report describes a large case series of NDM-producing E. coli infection. Patients with significant comorbidities remain at high risk for CRE infection. Antibiotic options for the treatment of NDM organisms are very limited; new and ef…
View article: Risk Factors and Outcomes of Candida auris in Southeast Michigan
Risk Factors and Outcomes of Candida auris in Southeast Michigan Open
Background: Candida auris is an emerging multidrug resistant fungus that presents a serious global health threat and causes severe infections with a high mortality rate in hospitalized patients with significant underlying comorbidities. We…
View article: Hospital-Onset Clostridioides difficile infection in chronic kidney disease patients
Hospital-Onset Clostridioides difficile infection in chronic kidney disease patients Open
Introduction: Hospital-onset Clostridioides difficile infection (HO-CDI), reported as laboratory-identified (LabID) event, is common in patients with chronic kidney disease (CKD), especially those with end-stage renal disease (ESRD), and i…
View article: Characteristics, Treatment, and Outcomes of Invasive Group A Streptococcal Infections
Characteristics, Treatment, and Outcomes of Invasive Group A Streptococcal Infections Open
Background: Group A Streptococcus (GAS; Streptococcus pyogenes) is an important human pathogen that can cause life-threatening invasive disease, ranging from skin/soft tissue infections to infective endocarditis. In the fall of 2022, the C…
View article: Use of whole genomic sequencing to detect New Delhi metallo-B-lactamase (NDM)-producing <i>Escherichia coli</i> outbreak associated with endoscopic procedures
Use of whole genomic sequencing to detect New Delhi metallo-B-lactamase (NDM)-producing <i>Escherichia coli</i> outbreak associated with endoscopic procedures Open
Background: Whole-genome sequencing (WGS) has emerged as an alternative genotyping tool for outbreak investigations in the healthcare setting. We describe the investigation and control of a New Delhi metallo-B-lactamase (NDM)-producing Esc…
View article: LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in <i>Enterococcus faecium</i>
LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in <i>Enterococcus faecium</i> Open
Daptomycin (DAP) is often used as a first-line therapy to treat vancomycin-resistant Enterococcus faecium infections, but emergence of DAP non-susceptibility threatens the effectiveness of this antibiotic. Moreover, current methods to dete…
View article: Using interprofessional collaboration to reduce reported rates of central-line–associated bloodstream infection in an intensive care setting
Using interprofessional collaboration to reduce reported rates of central-line–associated bloodstream infection in an intensive care setting Open
Using a multicomponent approach that included blood-culture stewardship, evaluation for secondary sources of bloodstream infection, improved documentation, and prompt central-line removal, an interprofessional team improved patient care an…
View article: Outcomes in patients with sarcoidosis and COVID-19.
Outcomes in patients with sarcoidosis and COVID-19. Open
Patients with sarcoidosis may not be at increased risk of critical illness or death from COVID-19, and immunosuppression therapy in these patients may reduce the risk of critical COVID-19.
View article: 1856. Barriers to Improving Outcomes among People Experiencing Homelessness and People Who Inject Drugs Hospitalized for Complicated Infections
1856. Barriers to Improving Outcomes among People Experiencing Homelessness and People Who Inject Drugs Hospitalized for Complicated Infections Open
Background People experiencing homelessness (PEH) and people who inject drugs (PWID) experience health disparities and worse outcomes. Challenges include suboptimal medication use, loss to follow-up, and non-compliance due to social determ…
View article: 2299. Genomic Epidemiology of <i>SARS-CoV-2</i> in Metropolitan Detroit
2299. Genomic Epidemiology of <i>SARS-CoV-2</i> in Metropolitan Detroit Open
Background The COVID-19 pandemic, resulting from the rapidly evolving SARS-CoV-2 virus, has drastically impacted health systems and economies worldwide. Genomic sequencing is critical for the surveillance of SARS-CoV-2 to monitor the rapid…