Explanipedia

Trends of prenatal opioid utilization and neonatal abstinence syndrome in Manitoba, Canada: A 26-year population-based cohort study Open

Omaymah Abulannaz, Chelsea Ruth, Roxana Drăgan, Brenden Dufault, Andi Camden , et al. · 2025

Background Opioids are prescribed for pain and as opioid agonist therapy for opioid use disorder. This can lead to neonatal abstinence syndrome (NAS) in newborns when used in pregnancy. Few studies have described trends in prenatal opioid …

Améliorer la réglementation du cannabis médical au Canada pour mieux servir les patients pédiatriques Open

Richard J. Huntsman, Lauren E. Kelly, Jane Alcorn, Juan Pablo Appendino, Richard E. Bélanger , et al. · 2021

Points clés Les enfants atteints de maladies chroniques invalidantes et douloureuses utilisent de plus en plus le cannabis médical, particulièrement lorsque les options thérapeutiques classiques sont peu efficaces ou provoquent des effets …

Improving the regulation of medical cannabis in Canada to better serve pediatric patients Open

Richard J. Huntsman, Lauren E. Kelly, Jane Alcorn, Juan Pablo Appendino, Richard E. Bélanger , et al. · 2021

Key points Children with chronic debilitating illness and pain are increasingly using cannabis for medical purposes, particularly when conventional treatment options have limited benefit or substantial adverse effects. Caregivers are becom…

L’asthme et la COVID-19 Open

Elissa M. Abrams, Geert W. ‘t Jong, Connie Yang · 2020

Selon les données recueillies à ce jour, les personnes asthmatiques seraient surreprésentées parmi les adultes hospitalisés pour la COVID-19 (maladie à coronavirus 2019)[1][1],[2][2]. Cette surreprésentation pourrait être due au fait que l…

Non-steroidal or opioid analgesia use for children with musculoskeletal injuries (the No OUCH study): statistical analysis plan Open

Anna Heath, Maryna Yaskina, Gareth Hopkin, Terry P. Klassen, Christopher McCabe , et al. · 2020

Asthma and COVID-19 Open

Elissa M. Abrams, Geert W. ‘t Jong, Connie Yang · 2020

There is some evidence to date that those with asthma are overrepresented among the adult patients who have been admitted to hospital with coronavirus disease 2019 (COVID-19).[1][1],[2][2] This overrepresentation may occur because severe a…

Innovative approaches to investigator-initiated, multicentre paediatric clinical trials in Canada Open

Lauren E. Kelly, Lawrence Richer, Samina Ali, Amy C. Plint, Naveen Poonai , et al. · 2019

Data from clinical trials are needed to guide the safe and effective use of medicines in children. Clinical trials are challenging to design and implement in all populations, and children present additional considerations. Several regions …

Maternal antibiotic exposure during pregnancy and hospitalization with infection in offspring Open

Abin Chandrakumar, Aseem Bhardwaj, Geert W. ‘t Jong · 2018

Antibiotic-Induced Liver Injury in Paediatric Outpatients: A Case-Control Study in Primary Care Databases Open

Carmen Ferrajolo, Katia Verhamme, Gianluca Trifirò, Geert W. ‘t Jong, Gino Picelli , et al. · 2016

Adverse drug reactions in a primary care population prescribed non-steroidal anti-inflammatory drugs Open

Aafke R Koffeman, Amanda R. van Buul, Vera E. Valkhoff, Geert W. ‘t Jong, Patrick Bindels , et al. · 2015

Of the patients with MSK complaints prescribed an NSAID, almost one in 30 patients re-consulted their GP with a complaint likely or possibly associated with the use of this drug. The burden of such consultations for non-serious ADRs should…

Time‐trends in the prescribing of gastroprotective agents to primary care patients initiating low‐dose aspirin or non‐steroidal anti‐inflammatory drugs: a population‐based cohort study Open

Margaretha F. Warlé‐van Herwaarden, Aafke R Koffeman, Vera E. Valkhoff, Geert W. ‘t Jong, Cornelis Kramers , et al. · 2015

Aims Low‐dose aspirin (LDA) and non‐steroidal‐anti‐inflammatory drugs (NSAIDs) both increase the risk of upper gastrointestinal events (UGIEs). In the Netherlands, recommendations regarding the prescription of gastroprotective agents (GPAs…

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