Explanipedia

Development and evaluation of berberine-loaded bigel for the treatment of hyperpigmentation on B16F10 melanoma cell line Open

Bharti Mangla, Pankaj Kumar, Zuber Ahamad, Shamama Javed, Waquar Ahsan , et al. · 2024

Aim: The aim of this study was to optimize, develop, characterize and evaluate a topical nanobigel (BG) formulation containing Berberine (BRB) that exhibits anti-melanogenic properties.Materials & methods: The Berberine-loade…

Effect of Different MCDM Techniques and Weighting Mechanisms on Women Vulnerability Index Open

Seema Aggarwal, Geeta Aggarwal, Manisha Bansal · 2024

Effect of Different MCDM Techniques and Weighting Mechanisms on Women Vulnerability Index Open

Seema Aggarwal, Geeta Aggarwal, Manisha Bansal · 2024

Crime against women is a chronic issue that saddens society and needs to be carefully addressed. The states of India exhibit significant variations in the incidence of criminal behavior. We created a novel index in our previous research to…

Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents Open

Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al‐Harrasi , et al. · 2024

The lipid-based drug delivery system (LBDDS) is a well-established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as tre…

Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain Open

Amit Sah, Geeta Aggarwal, Gaurav Jain, Syed Mohd Abbas Zaidi, Punnoth Poonkuzhi Naseef , et al. · 2023

The oil of the Unani medicinal herb Baboona (Matricaria chamomilla) has shown potential in the management of pain. However, predicaments such as poor skin penetration, skin sensitization, liable to degradation, and volatile nature restrict…

The emerging potential of siRNA nanotherapeutics in treatment of arthritis Open

Anjali Kumari, Amanpreet Kaur, Geeta Aggarwal · 2023

RNA interference (RNAi) using small interfering RNA (siRNA) has shown potential as a therapeutic option for the treatment of arthritis by silencing specific genes. However, siRNA delivery faces several challenges, including stability, targ…

A review of nanomaterials from synthetic and natural molecules for prospective breast cancer nanotherapy Open

Pankaj Kumar, Bharti Mangla, Shamama Javed, Waquar Ahsan, Pankaj Musyuni , et al. · 2023

Breast cancer being one of the most frequent cancers in women accounts for almost a quarter of all cancer cases. Early and late-stage breast cancer outcomes have improved dramatically, with considerable gains in overall survival rate and d…

Chitosan-Based Polymer Blends for Drug Delivery Systems Open

Malkiet Kaur, Ameya Sharma, Vivek Puri, Geeta Aggarwal, Paramjot Maman , et al. · 2023

Polymers have been widely used for the development of drug delivery systems accommodating the regulated release of therapeutic agents in consistent doses over a long period, cyclic dosing, and the adjustable release of both hydrophobic and…

An overview of regulation for nutraceuticals and concept of personalized nutraceuticals Open

Saurav Tomar, Pankaj Musyuni, Geeta Aggarwal · 2023

Nutraceuticals are essentially nutritional components that have a vital role in developing and maintaining the body’s regular functions, which keeps people healthy. The nutraceutical sector is also primarily driven by the existing global p…

Optimization and validation of stability indicating RP-HPLC method for the quantification of gefitinib in bulk drug and nanoformulations: An application towards in vitro and ex vivo performance evaluation Open

Pankaj Kumar, Bharti Mangla, Sarwar Beg, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi , et al. · 2022

Gefitinib (GFB) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used primarily to treat non-small cell lung cancer (NSCLC), but it also works by lowering AKT and MAPK phosphorylation, which makes it effective agains…

A Comprehensive Study of Therapeutic Applications of Chamomile Open

Amit Sah, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Gaurav Jain, Foziyah Zakir , et al. · 2022

Chamomile has a long history of traditional medicinal uses. The two commonly used varieties with therapeutic applications are German chamomile known as Matricaria chamomilla L. and Roman chamomile or Chamaemelum nobile L. The plant contain…

Drugs acting on the renin–angiotensin–aldosterone system (RAAS) and deaths of COVID-19 patients: a systematic review and meta-analysis of observational studies Open

Ruchika Sharma, Anoop Kumar, Jaseela Majeed, Ajit Kumar Thakur, Geeta Aggarwal · 2022

Background Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) are two of the most commonly used antihypertensive drugs acting on the renin–angiotensin–aldosterone system (RAAS). Previous research has s…

Exploring the Potential of Natural Product-Based Nanomedicine for Maintaining Oral Health Open

R. Arun Kumar, Mohd. Aamir Mirza, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Foziyah Zakir , et al. · 2022

Oral diseases pose a major threat to public health across the globe. Diseases such as dental caries, periodontitis, gingivitis, halitosis, and oral cancer affect people of all age groups. Moreover, unhealthy diet practices and the presence…

Essential oils for the treatment of skin anomalies: Scope and potential Open

Sunita Maddheshiya, Adil Ahmad, Wasim Ahmad, Foziyah Zakir, Geeta Aggarwal · 2022

Skin diseases contribute significantly to worldwide morbidity and mortality. It is the most common of all human diseases which can affect people of any age group. Most importantly, it is seen that the COVID-19 pandemic have further detrime…

Nanocarriers-Assisted Needle-Free Vaccine Delivery Through Oral and Intranasal Transmucosal Routes: A Novel Therapeutic Conduit Open

Bharti Mangla, Shamama Javed, Muhammad H. Sultan, Waquar Ahsan, Geeta Aggarwal , et al. · 2022

Drug delivery using oral route is the most popular, convenient, safest and least expensive approach. It includes oral transmucosal delivery of bioactive compounds as the mucosal cavity offers an intriguing approach for systemic drug distri…

Precision Medicine: An Emerging Paradigm for Improved Diagnosis and Safe Therapy in Pediatric Oncology Open

Puneet Singla, Pankaj Musyuni, Geeta Aggarwal, Harjinder Singh · 2021

POS-514 MULTI-CENTRIC HEMODIALYSIS ELECTRONIC PATIENT REPORTED OUTCOME MEASURES (ePROM) SURVEY Open

Arvind Conjeevaram, Geeta Aggarwal, Girish Namagondlu, Krishnam Raju Penmatsa, Manisha Dassi , et al. · 2021

Patient-reported outcome measures are widely used Internationally to report and monitor patients' subjective assessments of their symptoms, functional status and quality of life. They allow the efficacy of a clinical intervention to be mea…

Recent Advances in Diagnosis and Management of Myofascial Pain Syndrome: A Narrative Review Open

Shilpa Jain, Ramesh K. Goyal, Puneeta Ajmera, Geeta Aggarwal, Sapna Dhiman · 2021

Myofascial Pain Syndrome (MFPS) is a disorder common among patients who experience musculoskeletal pain. The condition originates from the muscles and the fascia which surrounds it. Initially, this condition used to be prevalent among peop…

An updated review on Materiovigilance for safe use of medical devices Open

Mansi Deshwal, Manju Nagpal, Gitika Arora Dhingra, Geeta Aggarwal · 2020

In the last two decades, there has been an upsurge in the volume of medical devices and thereby increasing medical device-related adverse events. So, materiovigilance is an essential system for identifying, collecting, reporting and analys…

Early Postoperative Death in Patients Undergoing Emergency High-Risk Surgery: Towards a Better Understanding of Patients for Whom Surgery May not Be Beneficial Open

Geeta Aggarwal, Katherine J. Broughton, Linda Williams, Carol J. Peden, Nial Quiney · 2020

The timing, causes, and quality of care for patients who die after emergency laparotomy have not been extensively reported. A large database of 13,953 patients undergoing emergency laparotomy, between July 2014 and March 2017, from 28 hosp…

Improved antibacterial activity of topical gel-based on nanosponge carrier of cinnamon oil Open

Malkiet Kaur, Manju Nagpal, Manjinder Singh, Thakur Gurjeet Singh, Geeta Aggarwal , et al. · 2020

Introduction: Cinnamon essential oil (CEO) is a volatile oil, obtained from Cinnamomum zeylanicum has become one of the most important natural oil due to its antimicrobial activity. CEO suffers from various limitations…

Development of binary dispersions and nanocomposites of irbesartan with enhanced antihypertensive activity Open

Vivek Puri, Manju Nagpal, Ameya Sharma, Thakur Gurjeet Singh, Manjinder Singh , et al. · 2019

Introduction: Irbesartan (IBS), an angiotensin II receptor (AT1 subtype) antagonist which blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selective binding to AT1 angiotensin II receptor. It belongs to BCS…

Inclusion complexes of atorvastatin calcium–sulfobutyl ether β cyclodextrin with enhanced hypolipidemic activity Open

Anureet Arora, Geeta Aggarwal, Thakur Gurjeet Singh, Manjinder Singh, Gitika Arora , et al. · 2019

Enhancement of Oral Bioavailability and Solid Dispersion: A ReviewNadia Saffoon, Riaz Uddin, Naz Hasan Huda, Kumar Bishwajit Sutradhar

HERBAL ACTIVE INGREDIENTS USED IN SKIN COSMETICS Open

Riya ARORA, Geeta Aggarwal, Gitika Arora Dhingra, Manju Nagpal · 2019

Human beings are obsessed with looking beautiful. Hence, various beauty products have been in use to look charming and young. Herbal ingredients are popular worldwide for use in cosmetics. The demand for herbal cosmetic is growing in the w…

Drug eluting sutures: A recent update Open

Anureet Arora, Geeta Aggarwal, Janita Chander, Paramjot Maman, Manju Nagpal · 2019

Fabrication of Buccal Dissolving Tetrahydro Curcumin Loaded Polyvidone Fiber Mat: Synthesis, Characterization, and In Vitro EvaluationsRavikumar Rramaswamy, Ganesh Mani, Hyun Tae Jang

Evaluation of the Collaborative Use of an Evidence-Based Care Bundle in Emergency Laparotomy Open

Geeta Aggarwal, Carol J. Peden, Mohammed A. Mohammed, Anne Pullyblank, Ben Ames Williams , et al. · 2019

A collaborative approach using a quality improvement methodology and a care bundle appeared to be effective in reducing mortality and length of stay in emergency laparotomy, suggesting that hospitals should adopt such an approach to see be…

Potential benefits of phytochemicals for treatment of hyperpigmentation Open

Harsimran Kaur, Afsana, Geeta Aggarwal, Manju Nagpal · 2019

UV radiation (UV) is considered as a complete carcinogen as it is both a mutagen and a non-specific damaging agent. It is the most important risk factor for skin cancer and many other skin disorders like Hyperpigmentation. There is a need …

Improved Prediction Based Mining Approach for Classification using Association rules Open

Kavita Mittal, Geeta Aggarwal, Prerna Mahajan · 2018

International Journal of Computer Sciences and Engineering (A UGC Approved and indexed with DOI, ICI and Approved, DPI Digital Library) is one of the leading and growing open access, peer-reviewed, monthly, and scientific research journal …

Cost‐effectiveness of a quality improvement bundle for emergency laparotomy Open

C. Ebm, Geeta Aggarwal, Sam Huddart, Maurizio Cecconi, Nial Quiney · 2018

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