Gehan A. Hegazy
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View article: Is it possible that combined alpha-tocopherol and CoQ10 can combat testicular injury induced by arsenic
Is it possible that combined alpha-tocopherol and CoQ10 can combat testicular injury induced by arsenic Open
Arsenic emerges as a significant public health issue. Therefore, it makes sense to identify appropriate compounds to alleviate arsenic toxicity. Alpha-tocopherol and Coenzyme Q10 were tested for their ability to avert arsenic effects. 30 m…
View article: Long noncoding RNAs in familial hypercholesterolemia: biomarkers, therapeutics, and AI in precision medicine
Long noncoding RNAs in familial hypercholesterolemia: biomarkers, therapeutics, and AI in precision medicine Open
View article: Expression of lncRNA NEAT1, miR-21, and IL17 in Rheumatoid Arthritis Patients
Expression of lncRNA NEAT1, miR-21, and IL17 in Rheumatoid Arthritis Patients Open
NEAT1, miR-21, and IL17 have differential levels in patients with RA where NEAT1 and IL17 have up regulation, while miR-21 has down regulation. NEAT1 has a significant correlation with RA disease activity. We recommend further research to …
View article: Six-step approach for developing customized GPT in medical education
Six-step approach for developing customized GPT in medical education Open
Incorporating generative AI into medical education is important nowadays. This study employs a six-step approach to establish guidelines for creating customized GPT models in this field. Following structured steps, we developed customized …
View article: Expression Levels of lncRNA NEAT1, miRNA-21, and IL-17 in a Group of Egyptian Patients with Behçet’s Disease: Relation to Disease Manifestations and Activity
Expression Levels of lncRNA NEAT1, miRNA-21, and IL-17 in a Group of Egyptian Patients with Behçet’s Disease: Relation to Disease Manifestations and Activity Open
NEAT1, miR-21 and IL17 might have a role in Behçet's disease pathogenesis, so more research is needed to unveil that role and their potential usage as biomarkers for the diagnosis or therapeutic targets.
View article: Significance of Interleukin 23 in Systemic Lupus Patients: Relation to Disease Activity and Damage Indices
Significance of Interleukin 23 in Systemic Lupus Patients: Relation to Disease Activity and Damage Indices Open
IL23 has higher levels in the serum of SLE patients, and is correlated to activity of the disease, especially lupus nephritis. Further researchis needed to explore its exact role in SLE pathogenesis and whether it can be considered a poten…
View article: Keratometric Outcomes after Simultaneous versus Sequential Intracorneal Ring Segment Implantation with Femtosecond Laser and Corneal Collagen Crosslinking in Egyptian Patients with Keratoconus and Ectasia
Keratometric Outcomes after Simultaneous versus Sequential Intracorneal Ring Segment Implantation with Femtosecond Laser and Corneal Collagen Crosslinking in Egyptian Patients with Keratoconus and Ectasia Open
Background: Keratoconus (KC) is degenerative corneal disorder, with central and paracentral thinning and corneal ectasia. For KC progressive cases, primary treatment included corneal collagen cross linking (CXL) to stabilize coning and int…
View article: Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells
Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells Open
View article: Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. <i>A case-control study</i>
Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. <i>A case-control study</i> Open
To evaluate adipokine serum values of irisin, retinol-binding protein 4, and leptin in Saudi cases with type 2 diabetes mellitus (T2DM) for providing markers of T2DM macrovascular complications. Methods: This case-control research was carr…
View article: Hepatoprotective effect of Moringa oleifera extract on TNF-α and TGF-β expression in acetaminophen-induced liver fibrosis in rats
Hepatoprotective effect of Moringa oleifera extract on TNF-α and TGF-β expression in acetaminophen-induced liver fibrosis in rats Open
Background It has been reported that Moringa oleifera (MO) has different medicinal properties. The aim of this study was to evaluate the hepatoprotective role of Moringa oleifera extract on acetaminophen-induced liver fibrosis in albino ra…
View article: Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism
Thymoquinone Enhances Paclitaxel Anti-Breast Cancer Activity via Inhibiting Tumor-Associated Stem Cells Despite Apparent Mathematical Antagonism Open
Thymoquinone (TQ) has shown substantial evidence for its anticancer effects. Using human breast cancer cells, we evaluated the chemomodulatory effect of TQ on paclitaxel (PTX). TQ showed weak cytotoxic properties against MCF-7 and T47D bre…
View article: Diet influences levels of plasma lipopolysaccharide (LPS) and its soluble receptor (sCD14) in Saudis
Diet influences levels of plasma lipopolysaccharide (LPS) and its soluble receptor (sCD14) in Saudis Open
An association between dietary composition and development of bacterial endotoxaemia was found. However, no association between measures of endotoxaemia and increased adiposity and inflammation was found.
View article: Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications
Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications Open
Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed to investigate serum levels of soluble vascular cell adhesion molecule 1 (sVCAM…
View article: Biomarkers of Systemic Lupus Erythematosus and Systemic Sclerosis diseases activity in a sample of Egyptian patients :Soluble Intercellular Adhesion Molecule-1 and Soluble Interleukin-2 Receptor, Case Control Study
Biomarkers of Systemic Lupus Erythematosus and Systemic Sclerosis diseases activity in a sample of Egyptian patients :Soluble Intercellular Adhesion Molecule-1 and Soluble Interleukin-2 Receptor, Case Control Study Open
Systemic Lupus Erythematosus (SLE) and systemic sclerosis (SSc) are systemic inflammatory autoimmune disorders characterized by a large spectrum of clinical and laboratory features. The aim of the present study was to investigate the possi…
View article: Liver ischemia/reperfusion injury, a setting in which the functional mass is reduced and the role of PDE5 inhibitor
Liver ischemia/reperfusion injury, a setting in which the functional mass is reduced and the role of PDE5 inhibitor Open
Liver ischemia reperfusion is induced during sur-gical procedures like liver transplantation and re-section. Multiple mechanisms have been postulat-ed to liver damage following liver ischemia reperfu-sion injury, such as oxidative stress a…
View article: Serum neutrophil gelatinase-associated lipocalin in obese adolescents
Serum neutrophil gelatinase-associated lipocalin in obese adolescents Open
View article: Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities
Thymoquinone synergizes gemcitabine anti-breast cancer activity via modulating its apoptotic and autophagic activities Open
View article: Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females
Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females Open
Oligonol could be suggested as future hypolipidemic and weight controlling agent for overweight and obese Saudi females.
View article: The Ameliorative Potential of Dexmedetomidine and Benincasa Cerifera Extract in Renal Ischemia/Reperfusion Injury in A Streptozotocin-Induced Diabetic Model
The Ameliorative Potential of Dexmedetomidine and Benincasa Cerifera Extract in Renal Ischemia/Reperfusion Injury in A Streptozotocin-Induced Diabetic Model Open
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View article: Oligonol Supplementation Decreases Cardiometabolic Risk Factors, and the Prevalence of Metabolic Syndrome in a Sample of Overweight and Obese Saudi Females
Oligonol Supplementation Decreases Cardiometabolic Risk Factors, and the Prevalence of Metabolic Syndrome in a Sample of Overweight and Obese Saudi Females Open
View article: A novel mutation in exon 1 of GATA4 in Egyptian patients with congenital heart disease
A novel mutation in exon 1 of GATA4 in Egyptian patients with congenital heart disease Open
There is a high prevalence of exon 1 GATA4 mutation (9.1%) in our study compared to other studies in different populations, which may correlate with different ethnic populations.
View article: Methylene tetrahydrofolate reductase, transforming growth factor-β1 and lymphotoxin-α genes polymorphisms and susceptibility to rheumatoid arthritis
Methylene tetrahydrofolate reductase, transforming growth factor-β1 and lymphotoxin-α genes polymorphisms and susceptibility to rheumatoid arthritis Open
Our findings suggest that there is association between MTHFR C677 T and LT-α A252G genes polymorphisms and increased risk of RA in this sample of Egyptian population.
View article: Polimorfismos dos genes metilenotetrahidrofolato redutase, fator de crescimento transformador β1 e linfotoxina‐α e susceptibilidade à artrite reumatoide
Polimorfismos dos genes metilenotetrahidrofolato redutase, fator de crescimento transformador β1 e linfotoxina‐α e susceptibilidade à artrite reumatoide Open
A artrite reumatoide é uma doença autoimune amplamente prevalente com sugerida predisposição genética. Detectar o padrão de polimorfismo dos genes metilenotetrahidrofolato redutase (MTHFR C677 T e A1298 C), fator de crescimento transformad…
View article: The association of vaspin rs2236242 and leptin rs7799039 polymorphism with metabolic syndrome in Egyptian women
The association of vaspin rs2236242 and leptin rs7799039 polymorphism with metabolic syndrome in Egyptian women Open
The AA genotype of leptin rs7799039 was associated with metabolic syndrome and higher serum leptin levels. Serum leptin and vaspin can be used as diagnostic markers of metabolic syndrome.
View article: The ameliorative potential of Hyphaene thebaica on streptozotocin-induced diabetic nephropathy
The ameliorative potential of Hyphaene thebaica on streptozotocin-induced diabetic nephropathy Open
Hyphaene thebaica may be advised as a good choice that can delay diabetic renal complications.
View article: Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats: Biochemical and immunohistochemical study
Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats: Biochemical and immunohistochemical study Open
It is concluded that pretreatment with CoQ10 and CS is associated with up-regulation of favorable protective enzymes and down-regulation of oxidative stress. That can be advised as a supplement to dox-treated patients.