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View article: Histological divergence underlying globular body shapes in ornamental goldfish
Histological divergence underlying globular body shapes in ornamental goldfish Open
Body shape diversity in vertebrates reflects a complex interplay between functional demands, environmental constraints, and internal developmental mechanisms. Various environments have promoted diverse morphological adaptations not only un…
View article: Actinotrichia-independent developmental mechanisms of spiny rays facilitate the morphological diversification of Acanthomorpha fish fins
Actinotrichia-independent developmental mechanisms of spiny rays facilitate the morphological diversification of Acanthomorpha fish fins Open
Skeletal forms in vertebrates have been regarded as good models of morphological diversification. Fish fin forms are greatly diversified, and their bone structure is classified into soft rays and spiny rays. In fish evolution, spiny-ray mo…
View article: Evolutionary Insights into Muscle Fiber Distribution in the Twin Tails of Ornamental Goldfish.
Evolutionary Insights into Muscle Fiber Distribution in the Twin Tails of Ornamental Goldfish. Open
Twin-tail ornamental goldfish have a bifurcated caudal fin with a morphology that is extremely divergent from the conventional body plan of the vertebrates. Here, we investigate the musculoskeletal histology of this bifurcated caudal fin. …
View article: Novel function of <i>Hox13</i> in regulating outgrowth of the newt hindlimb bud through interaction with <i>Fgf10</i> and <i>Tbx4</i>
Novel function of <i>Hox13</i> in regulating outgrowth of the newt hindlimb bud through interaction with <i>Fgf10</i> and <i>Tbx4</i> Open
5′ Hox genes regulate pattern formation along the axes of the limb. Previously, we showed that Hoxa13/Hoxd13 double‐mutant newts lacked all digits of the forelimbs during development and regeneration, showing that newt Hox13 is necessary f…
View article: Tracing of the developmental origin of the caudal fin muscle in zebrafish
Tracing of the developmental origin of the caudal fin muscle in zebrafish Open
Teleost species possess complex caudal musculoskeletal systems. While mid-trunk muscles exhibit simple segmental patterns, several caudal skeletal muscles display intricate orientations in their muscle fibers. Due to this distinctive morph…
View article: Novel function of<i>Hox13</i>in regulating outgrowth of the newt hindlimb bud through interaction with<i>Fgf10</i>and<i>Tbx4</i>
Novel function of<i>Hox13</i>in regulating outgrowth of the newt hindlimb bud through interaction with<i>Fgf10</i>and<i>Tbx4</i> Open
5’ Hox genes regulate pattern formation along the axes of the limb. Previously, we showed that Hoxa13/Hoxd13 double mutant newts lacked all digits of the forelimbs during development and regeneration, showing that newt Hox13 is necessary f…
View article: Anterior-posterior constraint on Hedgehog signaling by <i>hhip</i> in teleost fin elaboration
Anterior-posterior constraint on Hedgehog signaling by <i>hhip</i> in teleost fin elaboration Open
Pectoral fins, the anterior paired fins in fish, have enhanced maneuvering abilities due to morphological changes. Teleosts have fewer radial bones in their pectoral fins than basal species, resulting in more-elaborate fins. The mechanism …
View article: Evolutionary Insights into Muscle Fiber Distribution in the Twin Tails of Ornamental Goldfish
Evolutionary Insights into Muscle Fiber Distribution in the Twin Tails of Ornamental Goldfish Open
Twin-tail ornamental goldfish have a bifurcated caudal fin with a morphology that is extremely diverged from the conventional body plan of the vertebrates. Here, we investigate the musculoskeletal histology of this bifurcated caudal fin. F…
View article: Genomic screening of fish‐specific genes in gnathostomes and their functions in fin development
Genomic screening of fish‐specific genes in gnathostomes and their functions in fin development Open
In this study, we comprehensively searched for fish‐specific genes in gnathostomes that contribute to development of the fin, a fish‐specific trait. Many previous reports suggested that animal group‐specific genes are often important for g…
View article: The dwarf neon rainbowfish <i>Melanotaenia praecox</i>, a small spiny‐rayed fish with potential as a new <scp>Acanthomorpha</scp> model fish: <scp>I</scp>. <scp>Fin</scp> ray ontogeny and postembryonic staging
The dwarf neon rainbowfish <i>Melanotaenia praecox</i>, a small spiny‐rayed fish with potential as a new <span>Acanthomorpha</span> model fish: <span>I</span>. <span>Fin</span> ray ontogeny and postembryonic staging Open
Background Fish fins with highly variable color patterns and morphologies have many functions. In Actinopterygii, the free parts of fins are supported by “soft rays” and “spiny rays.” Spiny rays have various functions and are extremely mod…
View article: The dwarf neon rainbowfish <i>Melanotaenia praecox</i>, a small spiny‐rayed fish with potential as a new Acanthomorpha model fish: <scp>II</scp>. Establishment of a microinjection procedure for genetic engineering
The dwarf neon rainbowfish <i>Melanotaenia praecox</i>, a small spiny‐rayed fish with potential as a new Acanthomorpha model fish: <span>II</span>. Establishment of a microinjection procedure for genetic engineering Open
Background Rainbowfish is a clade of colorful freshwater fish. Melanotaenia praecox is a small rainbowfish species with biological characteristics that make it potentially useful as an experimental model species. We anticipate that M. prae…
View article: Fin elaboration via anterior-posterior regulation by Hedgehog signaling in teleosts
Fin elaboration via anterior-posterior regulation by Hedgehog signaling in teleosts Open
Fins in fishes are appendages that serve to facilitate maneuvering in water. Compared to their ancestral state, teleosts have reduced radial bones in their paired fin skeletons and have acquired elaborated, agile paired fins. We found that…
View article: Competition or contingency? Using CRISPR/Cas9-induced mutants to examine the potential origin of a unique mutant allele in twin-tail goldfish
Competition or contingency? Using CRISPR/Cas9-induced mutants to examine the potential origin of a unique mutant allele in twin-tail goldfish Open
Artificial selection has been widely applied to genetically fix rare phenotypic features in ornamental domesticated animals. For many of these animals, the mutated loci and alleles underlying rare phenotypes are known. However, few studies…
View article: Pleiotropic functions of chordin gene causing drastic morphological changes in ornamental goldfish
Pleiotropic functions of chordin gene causing drastic morphological changes in ornamental goldfish Open
Breeders and fanciers have established many peculiar morphological phenotypes in ornamental goldfish. Among them, the twin-tail and dorsal-finless phenotypes have particularly intrigued early and recent researchers, as equivalent morpholog…
View article: Morphological evolution and diversity of pectoral fin skeletons in teleosts
Morphological evolution and diversity of pectoral fin skeletons in teleosts Open
The Teleostei class has the most species of the fishes. Members of this group have paired rostral appendages and pectoral fins, enabling refined movements in the water. Although teleosts live in a diverse set of environments, the skeletal …
View article: Developmental Independence of Median Fins From the larval Fin Fold Revises Their Evolutionary Origin
Developmental Independence of Median Fins From the larval Fin Fold Revises Their Evolutionary Origin Open
The median fins in modern fish that show separated forms (dorsal, anal, and caudal fins) are derived from a continuous fold-like structure, both in ontogeny and phylogeny. The median fin fold (MFF) hypothesis assumes that the median fins e…
View article: Generating libraries of iTol2-end insertions at BAC ends using loxP and lox511 Tn10 transposons
Generating libraries of iTol2-end insertions at BAC ends using loxP and lox511 Tn10 transposons Open
BackgroundBacterial Artificial Chromosomes (BACs) have been widely used as transgenes in vertebrate model systems such as mice and zebrafish, for a variety of studies. BAC transgenesis has been a powerful tool to study the function of the …
View article: PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide
PLZF is a new substrate of CRBN with thalidomide and 5-hydroxythalidomide Open
Thalidomide induces cereblon (CRBN)-dependent degradation of proteins. Human cytochrome P450s are thought to provide two monohydroxylated metabolites from thalidomide, and the metabolites are also considered to be involved in thalidomide e…
View article: Regrowth of zebrafish caudal fin regeneration is determined by the amputated length
Regrowth of zebrafish caudal fin regeneration is determined by the amputated length Open
Fish have a high ability to regenerate fins, including the caudal fin. After caudal fin amputation, original bi-lobed morphology is reconstructed during its rapid regrowth. It is still controversial whether positional memory in the blastem…
View article: Embryonic and postembryonic development of the ornamental twin‐tail goldfish
Embryonic and postembryonic development of the ornamental twin‐tail goldfish Open
Background Twin‐tail ornamental goldfish have “bifurcated median fins,” a peculiar morphology known to be caused by a mutation in the chdA gene. However, several ambiguities regarding the development of the phenotype remain due to a paucit…
View article: Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum
Morphogenetic mechanism of the acquisition of the dinosaur-type acetabulum Open
Understanding morphological evolution in dinosaurs from a mechanistic viewpoint requires the elucidation of the morphogenesis that gave rise to derived dinosaurian traits, such as the perforated acetabulum. In the current study, we used em…
View article: A novel allele of the goldfish <i>chdB</i> gene: Functional evaluation and evolutionary considerations
A novel allele of the goldfish <i>chdB</i> gene: Functional evaluation and evolutionary considerations Open
The twin tail of ornamental goldfish is known to be caused by a nonsense mutation in one chordin paralogue gene. Our previous molecular studies in goldfish revealed that the ancestral chordin gene was duplicated, creating the chdA and chdB…
View article: An alternative evolutionary pathway for the twin‐tail goldfish via <i>szl</i> gene mutation
An alternative evolutionary pathway for the twin‐tail goldfish via <i>szl</i> gene mutation Open
The twin‐tail of ornamental goldfish provides unique evolutionary evidence that the highly conserved midline localization of axial skeleton components can be changed by artificial selection. This morphological change is known to be caused …
View article: Flight feather development: its early specialization during embryogenesis
Flight feather development: its early specialization during embryogenesis Open
The morphogenesis for the flight feather, the most advanced type of feather, has been drastically modified from the beginning of feather morphogenesis, suggesting that early modification of the embryonic morphogenetic process may have play…