Gemma M. Ryan
YOU?
Author Swipe
View article: DMPC/Chol liposomal copper CX5461 is therapeutically superior to a DSPC/Chol formulation
DMPC/Chol liposomal copper CX5461 is therapeutically superior to a DSPC/Chol formulation Open
CX5461, a compound initially identified as an RNA polymerase inhibitor and more recently as a G-quadruplex binder, binds copper to form a complex. Our previous publication showed that the complexation reaction can be leveraged to formulate…
View article: Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response
Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response Open
Tumours are complex systems of genetically diverse malignant cells that proliferate in the presence of a heterogeneous microenvironment consisting of host derived microvasculature, stromal, and immune cells. The components of the tumour mi…
View article: Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status
Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status Open
Summary Insensitivity to platinum, either through inherent or acquired resistance, is a major clinical problem in the treatment of many solid tumors. Here, we explored the therapeutic potential of diethyldithiocarbamate (DDC), pyrithione (…
View article: Targeting metastatic cancer using dendrimer-based drug delivery systems
Targeting metastatic cancer using dendrimer-based drug delivery systems Open
Effective treatment of metastatic tumours is hampered by poor distribution of small molecule chemotherapeutic drugs to distal sites of metastatic growth. This thesis has examined the potential for nano-sized drug carriers, and in particula…
View article: Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumour-burdened lymph nodes after intravenous and subcutaneous administration in rats Open
The current study sought to explore whether the subcutaneous administration of lymph-targeted dendrimers, conjugated with a model chemotherapeutic (methotrexate, MTX), was able to enhance anticancer activity against lymph node metastases. …