Explanipedia

Bone status in patients with chronic hypoparathyroidism: results from the Italian HypoparaNET database Open

Francesca Marini, Francesca Giusti, Blandine Weiss, Michel Ovize, Salvatore Benvenga , et al. · 2025

Background Chronic hypoparathyroidism (HypoPT) is a rare endocrine condition, having variable etiology, characterized by low parathyroid hormone levels, leading to reduced calcium levels and increased phosphorus values in the blood. Bone h…

Predictors of response to burosumab in adults with X-linked hypophosphatemia: real-world data from an Italian cohort Open

Gaetano Paride Arcidiacono, Valentina Camozzi, Giovanni Tripepi, Cristina Eller-Vainicher, Giuseppe Vezzoli , et al. · 2025

The Diagnosis and Therapy of Osteoporosis in Gaucher Disease Open

Gemma Marcucci, Maria Luisa Brandi · 2025

Study on critical illness and bone turnover Open

Gemma Marcucci, Morena Cozzolino, Mirko Duradoni, Simone Parri, Caterina Fossi , et al. · 2023

Purpose: Critical illness has been recognized to acutely influence bone metabolism and, consequently, bone mineral density. The main purpose of this study was to describe bone metabolism changes in adult survivors of critical illness in an…

Oxidative Stress and Natural Antioxidants in Osteoporosis: Novel Preventive and Therapeutic Approaches Open

Gemma Marcucci, Vladana Domazetovic, Chiara Nediani, Jessica Ruzzolini, Claudio Favre , et al. · 2023

This review reports in detail the cellular and molecular mechanisms which regulate the bone remodeling process in relation to oxidative stress (OS), inflammatory factors, and estrogen deficiency. OS is considered an important pathogenic fa…

Author Correction: Skeletal and extraskeletal disorders of biomineralization Open

Michael T. Collins, Gemma Marcucci, Hans‐Joachim Anders, Giovanni Beltrami, Jane A. Cauley , et al. · 2022

Rachitismo ipofosfatemico legato al cromosoma X (XLH) nel paziente adulto Open

Gemma Marcucci, Maria Luisa Brandi · 2022

Sommario Il rachitismo ipofosfatemico legato al cromosoma X (XLH) è una rara malattia congenita caratterizzata da perdita renale del fosfato e conseguente ipofosfatemia. I pazienti adulti con XLH possono presentare manifestazioni cliniche …

Multicenter retro-prospective observational study on chronic hypoparathyroidism and rhPTH (1–84) treatment Open

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti , et al. · 2022

Purpose The main purpose of this study was to investigate the effects of 12 months of rhPTH (1–84) (Natpar ® ) treatment in a cohort of patients selected according to the indications of hypoparathyroidism guidelines. The use of recombinant…

Effect of Oxidative Stress-Induced Apoptosis on Active FGF23 Levels in MLO-Y4 Cells: The Protective Role of 17-β-Estradiol Open

Vladana Domazetovic, Irene Falsetti, Simone Ciuffi, Teresa Iantomasi, Gemma Marcucci , et al. · 2022

The discovery that osteocytes secrete phosphaturic fibroblast growth factor 23 (FGF23) has defined bone as an endocrine organ. However, the autocrine and paracrine functions of FGF23 are still unknown. The present study focuses on the cell…

A Prospective Study on Critical Illness and Changes in Bone Turnover in Adult Patients Open

Gemma Marcucci, Morena Cozzolino, Mirko Duradoni, Simone Parri, Caterina Fossi , et al. · 2022

Critical illness has been recognized to acutely influence bone metabolism and, consequently, bone mineral density. The main purpose of this study was to describe bone metabolism changes in adult survivors of critical illness in the attempt…

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment Open

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti , et al. · 2021

The use of recombinant human PTH (1-84) [rhPTH(1-84)] is approved as hormonal replacement therapy in patients with hypoparathyroidism not adequately controlled with conventional therapy. The objective of this study was to investigate the e…

ALPLGenotypes in Patients With Atypical Femur Fractures or Other Biochemical and Clinical Signs of Hypophosphatasia Open

Francesca Marini, Laura Masi, Francesca Giusti, Luisella Cianferotti, Federica Cioppi , et al. · 2021

Context Hypophosphatasia (HPP) is a rare metabolic disorder caused by deficiency of alkaline phosphatase (ALP) enzyme activity, leading to defective mineralization, due to pathogenic variants of the ALPL gene, encoding the tissue nonspecif…

In Vitro Non-Genomic Effects of Calcifediol on Human Preosteoblastic Cells Open

Simone Donati, Gaia Palmini, Cecilia Romagnoli, Cinzia Aurilia, Francesca Miglietta , et al. · 2021

Several recent studies have demonstrated that the direct precursor of vitamin D3, the calcifediol [25(OH)D3], through the binding to the nuclear vitamin D receptor (VDR), is able to regulate the expression of many genes involved in several…

Hypoparathyroidism and pseudohypoparathyroidism in pregnancy: an Italian retrospective observational study Open

Gemma Marcucci, Paola Altieri, Salvatore Benvenga, Marta Bondanelli, Valentina Camozzi , et al. · 2021

Polymorphic variants of alkaline phosphatase gene correlate with clinical signs of adult hypophosphatasia? Open

Laura Masi, Francesca Marini, Francesco Franceschelli, Gigliola Leoncini, Luisella Cianferotti , et al. · 2021

Chronic hypoparathyroidism and treatment with teriparatide Open

Gemma Marcucci, Laura Masi, Luisella Cianferotti, Francesca Giusti, Caterina Fossi , et al. · 2021

Hypoparathyroidism and Pseudohypoparathyroidism in Pregnancy: An Italian Retrospective Observational Study Open

Gemma Marcucci, Paola Altieri, Salvatore Benvenga, Marta Bondanelli, Valentina Camozzi , et al. · 2020

Background: Hypoparathyroidism (HypoPT) or pseudo-hypoparathyroidism (pseudo-HypoPT) during pregnancy may cause maternal and fetal/neonatal complications. In this regard, only a few case reports or case series of pregnant or lactating wome…

Blueberry Juice Antioxidants Protect Osteogenic Activity against Oxidative Stress and Improve Long-Term Activation of the Mineralization Process in Human Osteoblast-Like SaOS-2 Cells: Involvement of SIRT1 Open

Vladana Domazetovic, Gemma Marcucci, Irene Falsetti, Anna Rita Bilia, M. Vincenzini , et al. · 2020

Diets rich in fruits and vegetables with many antioxidants can be very important in the prevention and treatment of osteoporosis. Studies show that oxidative stress, often due to lack of antioxidants, is involved in alteration of bone remo…

Bone health in childhood cancer: review of the literature and recommendations for the management of bone health in childhood cancer survivors Open

Gemma Marcucci, Giovanni Beltrami, A. Tamburini, Jean‐Jacques Body, C Confavreux , et al. · 2019

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1 Open

Vladana Domazetovic, Gemma Marcucci, Federica Pierucci, Gennaro Bruno, Lorenzo Di Cesare Mannelli , et al. · 2019

Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or ma…

Calcium Intake in Bone Health: A Focus on Calcium-Rich Mineral Waters Open

Letizia Vannucci, Caterina Fossi, Sara Quattrini, Leonardo Guasti, Barbara Pampaloni , et al. · 2018

Calcium is an essential element that plays numerous biological functions in the human body, of which one of the most important is skeleton mineralization. Bone is a mineralized connective tissue in which calcium represents the major compon…

Clinical presentation and management of hypoparathyroidism Open

Gemma Marcucci, Luisella Cianferotti, Maria Luisa Brandi · 2018

Causes and pathophysiology of hypoparathyroidism Open

Luisella Cianferotti, Gemma Marcucci, Maria Luisa Brandi · 2018

Phosphate wasting disorders in adults Open

Gemma Marcucci, Laura Masi, Serge Ferrari, Dieter Haffner, M K Javaid , et al. · 2018

HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy Open

Gemma Marcucci, Luisella Cianferotti, Simone Parri, Paola Altieri, Emanuela Arvat , et al. · 2018

Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology Open

Umberto Tarantino, Giovanni Iolascon, Luisella Cianferotti, Laura Masi, Gemma Marcucci , et al. · 2017

The first up-to-date Italian guidelines for the primary, secondary, and tertiary prevention of osteoporosis and osteoporotic fractures are presented.

Estrogen inhibits starvation‐induced apoptosis in osteocytes by a redox‐independent process involving association of JNK and glutathione S‐transferase P1‐1 Open

Vladana Domazetovic, Filippo Fontani, Gemma Marcucci, Teresa Iantomasi, Maria Luisa Brandi , et al. · 2017

Estrogen deficiency causes bone loss as a result of microdamage, oxidative stress, and osteocyte apoptosis. A relationship between oxidative stress‐induced apoptosis, c‐Jun N‐terminal kinase ( JNK ) activation, and expression of factors in…

Oxidative stress in bone remodeling: role of antioxidants Open

Vladana Domazetovic, Gemma Marcucci, Teresa Iantomasi, Maria Luisa Brandi, M. Vincenzini · 2017

ROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of…

Rare causes of osteoporosis Open

Gemma Marcucci · 2015

Osteoporosis is a metabolic bone disease characterized by loss of bone mass and strength, resulting in increased risk of fractures. It is classically divided into primary (post-menopausal or senile), secondary and idiopathic forms. There a…

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