Explanipedia

Novel thermoplastic splint for treating congenital auricular deformities with late initiation of treatment Open

Tatsuhiro Suzuki, Shinji Kumegawa, Maiko Inada, Yasuhiro Sakata, Yoshitaka Wada , et al. · 2025

Non-surgical treatment for congenital auricular deformities is commonly performed and has relatively favorable outcomes. However, delayed treatment could result in a poor response rate, eventually requiring surgical treatment. Effective no…

Scenario-Based Carbon Footprint of a Synthetic Liquid Fuel Vehicle Open

Gen Yamada, Hidenori Murata, Hideki Kobayashi · 2025

The mitigation of climate change impacts from the automotive sector is important for sustainable development, and for that purpose, synthetic liquid fuel vehicles (SLF-Vs) are being considered as a potential clean option alongside electric…

Consecutive Uncontrolled Gastrointestinal Immune-Related Adverse Events Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma: A Case Report Open

Yoshinori Toshima, Keiki Yokoo, Kaori Kamata, Takayuki Nagao, Satoshi Ota , et al. · 2025

Introduction: Immune-checkpoint inhibitors, such as pembrolizumab, have been used for non-small cell lung cancer treatment but are often associated with immune-related adverse events (irAEs). Case Presentation: A 71-year-old female was dia…

Topohistological alignments of ocular/penile organs Open

Gen Yamada, Daiki Hashimoto, Kota Fujimoto, Masanori Nakata, Shinichi Asamura , et al. · 2025

Mammalian visual and genital (hereafter mainly penile) organs have been extensively studied albeit separately. Both organ systems contain sensation devices necessary for visual perception and sexual intercourse. Their terminal structures a…

Spinal cord leptomeningeal myelomatosis Open

Gen Yamada, Guilherme Duffles, Carmino Antonio de Souza, Fabiano Reis · 2025

Analgesic effects of intraarterial injection of imipenem/cilastatin sodium in a rat model of knee osteoarthritis Open

Yuki Matsuyama, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Hidenobu Tamai , et al. · 2025

Angiogenesis plays a role in the mechanism underlying musculoskeletal pain; thus, embolization of blood vessels may exert an analgesic effect. Recent clinical studies have reported promising therapeutic outcomes for arterial embolization i…

Dynamics of Immune Cell Infiltration and Fibroblast-Derived IL-33/ST2 Axis Induction in a Mouse Model of Post-Surgical Lymphedema Open

Kazuhisa Uemura, Keiichi Katayama, Toshihiko Nishioka, Hikaru Watanabe, Gen Yamada , et al. · 2025

Lymphedema is an intractable disease most commonly associated with lymph node dissection for cancer treatment and can lead to a decreased quality of life. Type 2 T helper (Th2) lymphocytes have been shown to be important in the progression…

Interstitial Lung Disease due to Tepotinib after Durvalumab in a Patient with Lung Adenocarcinoma Harbouring MET Exon 14 Skipping Mutation: A Case Report Open

Ryota Tatsuhige, Keiki Yokoo, Taku Hatakeyama, Takayuki Nagao, Satoshi Ota , et al. · 2025

Introduction: Tepotinib is a targeted agent for patients with advanced non-small cell lung cancer (NSCLC) with MET exon 14 skipping mutation (METex14). Whereas durvalumab is an immune-checkpoint inhibitor (ICI), which has been administered…

Postnatal Bimodal Dynamics of Androgen-Dependent Corpus Cavernosum Development in Mice Open

Junki Aikawa, Mizuki Kajimoto, Yu Hatano, Chongming Wu, Norifumi Sawada , et al. · 2025

Ultrasound Irradiation as a Candidate Procedure to Improve the Transdermal Drug Delivery to the Tail Edema of a Mouse Model Open

Shinji Kumegawa, Takuya Suzuki, Kota Fujimoto, Kazuhisa Uemura, Katsuro Tachibana , et al. · 2024

Drug therapy for secondary lymphedema has not yet been established. Conventional oral and intravenous administration is difficult to administer in sufficient doses due to adverse events. Therefore, it is necessary to develop a transdermal …

Comparative Analyses Reveal Conserved and Modified Steps in the Testis Descent and Scrotum Development in Mouse and Opossum Open

Yoshio Wakamatsu, Yawara Takeda, Koji Tamura, Kunihiro Suzuki, Hiroshi Kiyonari , et al. · 2024

Introduction: In many mammals, the testes descend from its abdominal position on the mesonephric kidney and are housed in the scrotum. It has been speculated that metatherians and eutherians might have acquired the scrotal testis independe…

Extensive-Disease Small-Cell Lung Cancer With Severe Immune-Related Adverse Events Due to Atezolizumab Maintaining a Complete Response for Two Years: A Case Report Open

Sayaka Kudo, Keiki Yokoo, Nao Tanaka, Gen Yamada, Yasuo Kitamura · 2024

A 75-year-old male with diabetes mellitus was referred to our hospital with an abnormal shadow on chest radiography, based on which he was diagnosed with extensive-disease small-cell lung cancer (ED-SCLC; cT2bN2M1a). The first-line therapy…

Novel erectile analyses revealed augmentable penile Lyve‐1, the lymphatic marker, expression Open

Kota Fujimoto, Daiki Hashimoto, Sang Woon Kim, Yong Seung Lee, Takuya Suzuki , et al. · 2024

Purpose The pathophysiology of penis extends to erectile dysfunction (ED) to conditions including sexually transmitted diseases (STDs) and cancer. To date, there has been little research evaluating vascular drainage from the penis. We aime…

IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma Open

Hiroki Hosoi, S Tabata, Hideki Kosako, Yoshikazu Hori, Tadashi Okamura , et al. · 2024

IGLL5 is shown to be located near super-enhancer (SE) in B-cell tumors, and this gene is frequently mutated and a target of translocation in B-cell tumors. These results suggest roles of the IGLL5 in tumorigenesis; however, i…

Analgesic Effects of Intraarterial Injection of Imipenem Cilastatin Sodium in a Rat Model of Knee Osteoarthritis Open

Yuki Matsuyama, Manabu D. Yamanaka, Wataru Taniguchi, Naoko Nishio, Hidenobu Tamai , et al. · 2024

Developmental and functional roles of androgen and interactive signals for external genitalia and erectile tissues Open

Daiki Hashimoto, Kota Fujimoto, Masanori Nakata, Takuya Suzuki, Shinji Kumegawa , et al. · 2024

Background Recent progress in molecular and signal analyses revealed essential functions of cellular signals including androgen and related growth factors such as Wnt regulators for external genitalia (ExG) development and its pathogenesis…

Increased infiltration of CD4+ T cell in the complement deficient lymphedema model Open

Toshihiko Nishioka, Keiichi Katayama, Shinji Kumegawa, Kyoichi Isono, Takashi Baba , et al. · 2023

Background Lymphedema is an intractable disease that can be caused by injury to lymphatic vessels, such as by surgical treatments for cancer. It can lead to impaired joint mobility in the extremities and reduced quality of life. Chronic in…

Wound healing responses of urinary extravasation after urethral injury Open

Taiju Hyuga, Kota Fujimoto, Daiki Hashimoto, Kazuya Tanabe, Taro Kubo , et al. · 2023

The post-surgical fluid leakage from the tubular tissues is a critical symptom after gastrointestinal or urinary tract surgeries. Elucidating the mechanism for such abnormalities is vital in surgical and medical science. The exposure of th…

Relationship between immune‐related adverse events and treatment effectiveness in extensive disease small cell lung cancer Open

Keiki Yokoo, Yauo Kitamura, Keito Suzuki, Kohei Morikawa, Takeo Sawai , et al. · 2023

Background This study aimed to assess the relationship between immune response adverse events (irAEs) and treatment efficacy in patients with extensive disease small cell lung cancer (ED‐SCLC). Methods We retrospectively evaluated the clin…

Supplementary Figure 2, Video 4 from Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88) Open