Massimiliano Lanzafame
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View article: Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment
Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment Open
Background HLA-C molecules play a critical role in the immune response, particularly in antigen presentation and immune modulation. Methods To investigate the effect of the most common HLA-C allotypes on the stability of the HLA-C-β-2 micr…
View article: Bridging the gap in bloodstream infection management: a survey among non-infectious disease physicians
Bridging the gap in bloodstream infection management: a survey among non-infectious disease physicians Open
Objective Bloodstream infections (BSIs) significantly impact morbidity and mortality. Despite emerging evidence supporting optimal management, substantial variability persists among non-infectious disease (ID) physicians. This study assess…
View article: Rezafungin Utilisation in Real Life—<scp>FungiScope</scp> Results From Europe and the United States
Rezafungin Utilisation in Real Life—<span>FungiScope</span> Results From Europe and the United States Open
Background Rezafungin, a novel echinocandin with once‐weekly intravenous dosing, offers potential advantages for outpatient parenteral antifungal therapy (OPAT) in invasive candidiasis (IC). While clinical trial data support its efficacy a…
View article: A Precision Medicine Model for Targeted Antibiotic Therapy in Urinary Tract Infections: A Valuable Tool to Reduce Hospitalization Stay and the Time to Switch to Oral Treatment
A Precision Medicine Model for Targeted Antibiotic Therapy in Urinary Tract Infections: A Valuable Tool to Reduce Hospitalization Stay and the Time to Switch to Oral Treatment Open
Background/Objectives: The management of urinary tract infections (UTIs) has become an increasingly challenging medical intervention. This study explores whether adoption of a precision medicine model could improve the management of acute …
View article: Advances in HIV Treatment: Long-Acting Antiretrovirals and the Path Toward a Cure
Advances in HIV Treatment: Long-Acting Antiretrovirals and the Path Toward a Cure Open
Long-acting antiretroviral therapy (LA-ART) represents an important advancement in HIV care as it has considerably reduced the frequency of dosing and therefore improved adherence [...]
View article: Emerging strategies in tackling antimicrobial resistance in urology: Narrative review and expert opinion
Emerging strategies in tackling antimicrobial resistance in urology: Narrative review and expert opinion Open
Urinary tract infections (UTIs) are highly prevalent and frequently treated with antibiotics, making antimicrobial stewardship (AMS) crucial in this field to benefit both individual patients and society. This narrative review examines rece…
View article: Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up
Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up Open
Background: Antiretroviral triple therapy has considerably reduced morbidity and mortality in people living with HIV and is the standard-of-care treatment. However, it is lifelong and linked to long-term side effects and adherence problems…
View article: High malaria parasitemia in an Italian man and severe delayed hemolytic anemia
High malaria parasitemia in an Italian man and severe delayed hemolytic anemia Open
Key Clinical Message Parenteral artesunate has become the choice treatment of cases of high parasitemia malaria. We report the case of an Italian man with a high malaria parasitemia who promptly improved with intravenous artenusate, but wh…
View article: When an underestimated zoonosis and antimicrobial resistance collide: Corynebacterium ulcerans
When an underestimated zoonosis and antimicrobial resistance collide: Corynebacterium ulcerans Open
In the European region, diphtheria is now rarely suspected in patients presenting with upper respiratory tract symptoms. Corynebacterium ulcerans is the underestimated zoonosis that is replacing C. diphtheria infections in industrialized c…
View article: When an underestimated zoonosis and antimicrobial resistance collide: Corynebacterium ulcerans
When an underestimated zoonosis and antimicrobial resistance collide: Corynebacterium ulcerans Open
In the European region, diphtheria is now rarely suspected in patients presenting with upper respiratory tract symptoms. C. ulcerans is the underestimated zoonosis that is replacing C. diphtheria infections in industrialised countries, but…
View article: When an underestimated zoonosis and antimicrobial resistance collide: Corynebacterium ulcerans
When an underestimated zoonosis and antimicrobial resistance collide: Corynebacterium ulcerans Open
In the European region, diphtheria is now rarely suspected in patients presenting with upper respiratory tract symptoms. C. ulcerans is the underestimated zoonosis that is replacing C. diphtheria infections in industrialised countries. We …
View article: Short Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up
Short Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up Open
Short-cycle therapy has proven to be a safe and effective alternative to standard everyday antiretroviral treatment for virally suppressed people living with HIV. Here we report a favorable long-term virological and immunological outcome i…
View article: Cardiovascular Drug Interactions with Nirmatrelvir/Ritonavir for COVID-19: Considerations for Daily Practice
Cardiovascular Drug Interactions with Nirmatrelvir/Ritonavir for COVID-19: Considerations for Daily Practice Open
Cardiovascular disease is associated with progression to severe COVID-19 and patients with the condition are among those in whom early antiviral therapy should be warranted. The combination of nirmatrelvir/ritonavir (Paxlovid®) has been ap…
View article: HIV-1 RNA levels in semen of people on ‘short-cycle’ antiretroviral therapy
HIV-1 RNA levels in semen of people on ‘short-cycle’ antiretroviral therapy Open
Journal Article HIV-1 RNA levels in semen of people on 'short-cycle' antiretroviral therapy Get access Massimiliano Lanzafame, Massimiliano Lanzafame Unit of Infectious Diseases, Ospedale Santa Chiara, via Largo Medaglie d'oro 9 ,CAP 38122…
View article: Recurrent UTI: Questions and Answers on Clinical Practice
Recurrent UTI: Questions and Answers on Clinical Practice Open
Recurrent urinary tract infection (rUTI) management is still a challenge due to the lack of a standard approach and due to the burden of diseases both on personal and societal aspects. Consultations for rUTIs in everyday clinical practice …
View article: A 58‐year‐old man with B‐cell chronic lymphocytic leukemia and multiple strokes
A 58‐year‐old man with B‐cell chronic lymphocytic leukemia and multiple strokes Open
A 58-year-old male with B-cell chronic lymphocytic leukemia presented with fever, chest pain, and acute-onset neurological deficits suggestive of multiple strokes (A). Brain autopsy revealed softening areas in the brain parenchyma (B, C) c…
View article: Cardiovascular Diseases Associated Inflammatory Biomarker Levels in a Small Cohort of HIV-1 Infected Patients Deintensificated from Abacavir/Lamivudine/ Dolutegravir to Lamivudine Plus Dolutegravir Running Head: Risk of Cardiovascular Diseases and Abacavir Use
Cardiovascular Diseases Associated Inflammatory Biomarker Levels in a Small Cohort of HIV-1 Infected Patients Deintensificated from Abacavir/Lamivudine/ Dolutegravir to Lamivudine Plus Dolutegravir Running Head: Risk of Cardiovascular Diseases and Abacavir Use Open
Following the successful introduction of combined Antiretroviral Therapy (cART), a dramatic decrease in viral burden and opportunistic infections along with a consistent increase in life expectancy has been observed in Human Immunodeficien…
View article: Mini-review: Silico-tuberculosis
Mini-review: Silico-tuberculosis Open
Silicosis continues to be a serious health issue in many countries and its elimination by 2030 (a target set by WHO and the International Labour Organization in 1995) is virtually impossible. The risk to develop pulmonary tuberculosis for …