Geneviève Paulissen
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View article: JAK inhibitors alleviate metabolic dysregulation, inflammation and fibrosis in osteoarthritis: insights from human joint cells and synovium
JAK inhibitors alleviate metabolic dysregulation, inflammation and fibrosis in osteoarthritis: insights from human joint cells and synovium Open
Objectives Osteoarthritis (OA) presents a significant clinical challenge due to its heterogeneous nature, characterized by cartilage degradation, inflammation and fibrosis. Current treatments offer limited efficacy, highlighting the need f…
View article: ABS0108 CHARACTERIZATION OF CEMIP EXPRESSION PATTERNS, INCLUDING LOCALIZATION AND INTENSITY, IN SKIN BIOPSIES FROM PATIENTS WITH SYSTEMIC SCLEROSIS
ABS0108 CHARACTERIZATION OF CEMIP EXPRESSION PATTERNS, INCLUDING LOCALIZATION AND INTENSITY, IN SKIN BIOPSIES FROM PATIENTS WITH SYSTEMIC SCLEROSIS Open
View article: Overexpression and infiltration of ER stress proteins in the sublining layer of human inflamed synovial membranes
Overexpression and infiltration of ER stress proteins in the sublining layer of human inflamed synovial membranes Open
A strong crosstalk exists between endoplasmic reticulum (ER) stress and synovitis. Several ER chaperone proteins, besides their function in protein folding, can enhance inflammation and immunogenicity when secreted. This research aims at l…
View article: Impact of a Food Rebalancing Program Associated with Plant-Derived Food Supplements on the Biometric, Behavioral, and Biological Parameters of Obese Subjects
Impact of a Food Rebalancing Program Associated with Plant-Derived Food Supplements on the Biometric, Behavioral, and Biological Parameters of Obese Subjects Open
Between 2021 and 2023, the Scientific Council of Dietplus®, a group specialized in overweight and obesity management, conducted a clinical study on 170 volunteer subjects with a BMI > 29 Kg/m2 consecutively recruited. The Dietplus® program…
View article: CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane
CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane Open
Osteoarthritis (OA) synovial membrane is mainly characterized by low-grade inflammation, hyperplasia with increased cell proliferation and fibrosis. We previously underscored a critical role for CEMIP in fibrosis of OA cartilage. However, …
View article: New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases
New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases Open
An inflamed synovial membrane plays a major role in joint destruction and is characterized by immune cells infiltration and fibroblast proliferation. This proteomic study considers the inflammatory process at the molecular level by analyzi…
View article: Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes
Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes Open
Osteoarthritis (OA) is recognized as being a cellular senescence-linked disease. Intra-articular injections of glucocorticoids (GC) are frequently used in knee OA to treat synovial effusion but face controversies about toxicity. We investi…
View article: Correction: Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12
Correction: Control of Allergen-Induced Inflammation and Hyperresponsiveness by the Metalloproteinase ADAMTS-12 Open
Paulissen G., M. El Hour, N. Rocks, M. M. Guéders, F. Bureau, J.-M. Foidart, C. Lopez-Otin, A. Noel, and D. D. Cataldo. 2012. Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12. J. Immunol. …
View article: Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia
Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia Open
Loss of skeletal muscle mass in cancer cachexia is recognized as a predictor of mortality. This study aimed to characterize the changes in the muscle secretome associated with cancer cachexia to gain a better understanding of the mechanism…
View article: OR61: Skeletal Muscle as a Major Source of Acute-Phase Reactants (APR) During Cancer Cachexia
OR61: Skeletal Muscle as a Major Source of Acute-Phase Reactants (APR) During Cancer Cachexia Open
View article: DOP080 Endoplasmic reticulum stress in bordering epithelium of Crohn’s disease patients with intestinal fibrosis
DOP080 Endoplasmic reticulum stress in bordering epithelium of Crohn’s disease patients with intestinal fibrosis Open
Intestinal fibrosis in Crohn’s disease (CD) is complex and its initiation and progression are linked to chronic inflammation and lead to bowel damages. Bordering epithelium involvement in this process remains unravelled. Our purpose was to…
View article: Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages
Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages Open
View article: Lung-resident eosinophils represent a distinct regulatory eosinophil subset
Lung-resident eosinophils represent a distinct regulatory eosinophil subset Open
Increases in eosinophil numbers are associated with infection and allergic diseases, including asthma, but there is also evidence that eosinophils contribute to homeostatic immune processes. In mice, the normal lung contains resident eosin…